ATE199154T1 - 13-substituierte milbemycin 5-oxim derivate, ihre herstellung und verwendung gegen insekten und andere schädlinge - Google Patents
13-substituierte milbemycin 5-oxim derivate, ihre herstellung und verwendung gegen insekten und andere schädlingeInfo
- Publication number
- ATE199154T1 ATE199154T1 AT96307092T AT96307092T ATE199154T1 AT E199154 T1 ATE199154 T1 AT E199154T1 AT 96307092 T AT96307092 T AT 96307092T AT 96307092 T AT96307092 T AT 96307092T AT E199154 T1 ATE199154 T1 AT E199154T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- chem
- cycloalkyl
- carbocyclic aryl
- pests
- Prior art date
Links
- 241000238631 Hexapoda Species 0.000 title 1
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 230000000895 acaricidal effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000749 insecticidal effect Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25296595 | 1995-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199154T1 true ATE199154T1 (de) | 2001-02-15 |
Family
ID=17244627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96307092T ATE199154T1 (de) | 1995-09-29 | 1996-09-27 | 13-substituierte milbemycin 5-oxim derivate, ihre herstellung und verwendung gegen insekten und andere schädlinge |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5861429A (de) |
| EP (1) | EP0765879B1 (de) |
| KR (1) | KR100300376B1 (de) |
| AT (1) | ATE199154T1 (de) |
| AU (1) | AU707152B2 (de) |
| CA (1) | CA2186650A1 (de) |
| CZ (1) | CZ288178B6 (de) |
| DE (1) | DE69611773T2 (de) |
| DK (1) | DK0765879T3 (de) |
| ES (1) | ES2155172T3 (de) |
| GR (1) | GR3035565T3 (de) |
| HU (1) | HU225226B1 (de) |
| IL (1) | IL119321A (de) |
| NO (1) | NO317090B1 (de) |
| NZ (1) | NZ299460A (de) |
| PT (1) | PT765879E (de) |
| RU (1) | RU2128181C1 (de) |
| ZA (1) | ZA968183B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR035838A1 (es) | 1999-01-22 | 2004-07-21 | Elan Pharm Inc | Compuestos multiciclicos que inhiben la adhesion de leucocitos mediada por vla-4 y el uso de los mismos para la preparacion de un medicamento |
| HK1045157A1 (zh) | 1999-01-22 | 2002-11-15 | 依兰制药公司 | 抑制vla-4介导的白细胞粘着的化合物 |
| TW593284B (en) * | 1999-01-22 | 2004-06-21 | Elan Pharm Inc | Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| US6436904B1 (en) * | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| AU3246600A (en) | 1999-03-01 | 2000-09-21 | Elan Pharmaceuticals, Inc. | Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 receptor antagonists |
| NZ522247A (en) | 2000-04-27 | 2004-07-30 | Sankyo Lifetech Company Ltd | 13-substituted milbemycin derivatives, their preparation and their use against insects and other pests |
| RU2195280C1 (ru) * | 2001-05-21 | 2002-12-27 | Всероссийский научно-исследовательский институт гельминтологии им. К.И. Скрябина | Антигельминтное средство |
| KR20040047962A (ko) * | 2001-10-25 | 2004-06-05 | 상꾜 라이프테크 가부시키가이샤 | 기생충 구제 조성물 |
| TW200307671A (en) * | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| JP4373080B2 (ja) * | 2002-12-24 | 2009-11-25 | 三井化学アグロ株式会社 | ミルベマイシン類の精製法 |
| RU2355370C2 (ru) * | 2004-02-05 | 2009-05-20 | Ниппон Шокубаи Ко., Лтд. | Твердый водопоглощающий реагент и способ его изготовления, и водопоглощающее изделие |
| MX268188B (es) * | 2004-02-05 | 2009-07-09 | Nippon Catalytic Chem Ind | Agente absorbente de agua en particulas, y metodo para su produccion, y articulo para absorber agua. |
| TWI353360B (en) | 2005-04-07 | 2011-12-01 | Nippon Catalytic Chem Ind | Production process of polyacrylic acid (salt) wate |
| ATE493405T1 (de) * | 2005-09-29 | 2011-01-15 | Elan Pharm Inc | Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren |
| ZA200803016B (en) | 2005-09-29 | 2009-10-28 | Elan Pharmaceuticals Inc Wyeth | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| TWI394789B (zh) | 2005-12-22 | 2013-05-01 | Nippon Catalytic Chem Ind | 吸水性樹脂組成物及其製造方法、吸收性物品 |
| EA017110B1 (ru) * | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
| EP1837348B9 (de) | 2006-03-24 | 2020-01-08 | Nippon Shokubai Co.,Ltd. | Wasserabsorbierendes Harz und Verfahren zu seiner Herstellung |
| SG10201401836RA (en) * | 2009-04-27 | 2014-10-30 | Elan Pharm Inc | Pyridinone antagonists of alpha-4 integrins |
| CN102548654A (zh) | 2009-09-29 | 2012-07-04 | 株式会社日本触媒 | 颗粒状吸水剂及其制造方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| JPS4914624A (de) * | 1972-06-08 | 1974-02-08 | ||
| US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
| US4206205A (en) * | 1977-10-03 | 1980-06-03 | Merck & Co., Inc. | Monosaccharide and aglycone derivatives of C-076 |
| US4171314A (en) * | 1977-12-19 | 1979-10-16 | Merck & Co., Inc. | 13-Halo and 13-deoxy C-076 compounds |
| US4173571A (en) * | 1977-12-19 | 1979-11-06 | Merck & Co., Inc. | 13-Halo and 13-deoxy derivatives of C-076 compounds |
| US4203976A (en) * | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| JPS5632481A (en) * | 1979-08-23 | 1981-04-01 | Sankyo Co Ltd | Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent |
| US4289760A (en) * | 1980-05-02 | 1981-09-15 | Merck & Co., Inc. | 23-Keto derivatives of C-076 compounds |
| US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
| US4423209A (en) * | 1982-02-26 | 1983-12-27 | Merck & Co., Inc. | Processes for the interconversion of avermectin compounds |
| JPS59108785A (ja) * | 1982-11-25 | 1984-06-23 | Sankyo Co Ltd | ミルベマイシン類の５−オキシム誘導体 |
| US4579864A (en) * | 1984-06-11 | 1986-04-01 | Merck & Co., Inc. | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives |
| US4547491A (en) * | 1984-07-18 | 1985-10-15 | Merck & Co., Inc. | C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use |
| IL78621A (en) * | 1985-04-30 | 1991-06-30 | American Cyanamid Co | Mylbemycin analogs,their preparation and pesticidal compositions containing them |
| JPS6289685A (ja) * | 1985-05-31 | 1987-04-24 | Sankyo Co Ltd | １３−ハロゲンミルベマイシン誘導体 |
| US4668696A (en) * | 1985-07-29 | 1987-05-26 | Merck & Co., Inc. | Novel averonectin fermentation product of a microorganism with anthelmintic activity |
| US4778809A (en) * | 1985-08-23 | 1988-10-18 | Ciba-Geigy Corporation | 5-esters of milbemycins for controlling parasitic pests |
| RU2024527C1 (ru) * | 1986-03-25 | 1994-12-15 | Санкио Компани Лимитед | Способ получения макролидных соединений |
| GB8815967D0 (en) * | 1988-07-05 | 1988-08-10 | Pfizer Ltd | Antiparasitic agents |
| US5428034A (en) * | 1988-09-02 | 1995-06-27 | Sankyo Co., Ltd. | Milbemycin derivatives, their preparation and their use |
| KR0171426B1 (ko) * | 1991-12-18 | 1999-02-01 | 가와무라 요시부미 | 13-(치환 티오) 아세톡시밀베마이신 유도체, 그의 제조방법 및 농화학적 용도 |
| GB9201505D0 (en) * | 1992-01-24 | 1992-03-11 | Pfizer Ltd | Antiparasitic agents |
| GB9205051D0 (en) * | 1992-03-09 | 1992-04-22 | Cancer Res Campaign Tech | Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them |
| US5614470A (en) * | 1994-04-01 | 1997-03-25 | Sankyo Company, Limited | 13-substituted milbemycin derivatives, their preparation and their use |
| AU3935495A (en) * | 1994-11-24 | 1996-06-17 | Sankyo Company Limited | 13-etherified milbemycin derivative with insecticidal activity |
-
1996
- 1996-09-27 PT PT96307092T patent/PT765879E/pt unknown
- 1996-09-27 ES ES96307092T patent/ES2155172T3/es not_active Expired - Lifetime
- 1996-09-27 AU AU65861/96A patent/AU707152B2/en not_active Ceased
- 1996-09-27 DK DK96307092T patent/DK0765879T3/da active
- 1996-09-27 CZ CZ19962862A patent/CZ288178B6/cs not_active IP Right Cessation
- 1996-09-27 NZ NZ299460A patent/NZ299460A/en unknown
- 1996-09-27 AT AT96307092T patent/ATE199154T1/de not_active IP Right Cessation
- 1996-09-27 ZA ZA968183A patent/ZA968183B/xx unknown
- 1996-09-27 CA CA002186650A patent/CA2186650A1/en not_active Abandoned
- 1996-09-27 EP EP96307092A patent/EP0765879B1/de not_active Expired - Lifetime
- 1996-09-27 NO NO19964090A patent/NO317090B1/no not_active IP Right Cessation
- 1996-09-27 HU HU9602678A patent/HU225226B1/hu not_active IP Right Cessation
- 1996-09-27 DE DE69611773T patent/DE69611773T2/de not_active Expired - Lifetime
- 1996-09-29 IL IL11932196A patent/IL119321A/en not_active IP Right Cessation
- 1996-09-30 KR KR1019960042886A patent/KR100300376B1/ko not_active Expired - Fee Related
- 1996-09-30 US US08/723,835 patent/US5861429A/en not_active Expired - Fee Related
- 1996-09-30 RU RU96120138/04A patent/RU2128181C1/ru not_active IP Right Cessation
-
2001
- 2001-03-13 GR GR20010400411T patent/GR3035565T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ299460A (en) | 1997-12-19 |
| IL119321A (en) | 2001-05-20 |
| DK0765879T3 (da) | 2001-03-19 |
| CZ288178B6 (en) | 2001-05-16 |
| NO964090D0 (no) | 1996-09-27 |
| HU9602678D0 (en) | 1996-11-28 |
| RU2128181C1 (ru) | 1999-03-27 |
| DE69611773D1 (de) | 2001-03-22 |
| HK1003937A1 (en) | 1998-11-13 |
| DE69611773T2 (de) | 2001-09-13 |
| HU225226B1 (en) | 2006-08-28 |
| NO317090B1 (no) | 2004-08-02 |
| KR100300376B1 (ko) | 2001-10-22 |
| HUP9602678A1 (en) | 1997-11-28 |
| ZA968183B (en) | 1997-04-25 |
| ES2155172T3 (es) | 2001-05-01 |
| AU6586196A (en) | 1997-04-10 |
| CZ286296A3 (en) | 1997-04-16 |
| US5861429A (en) | 1999-01-19 |
| EP0765879A1 (de) | 1997-04-02 |
| GR3035565T3 (en) | 2001-06-29 |
| NO964090L (no) | 1997-04-01 |
| KR970015592A (ko) | 1997-04-28 |
| CA2186650A1 (en) | 1997-03-30 |
| AU707152B2 (en) | 1999-07-01 |
| EP0765879B1 (de) | 2001-02-14 |
| IL119321A0 (en) | 1996-12-05 |
| PT765879E (pt) | 2001-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |