NO20000452L - Sulfonylerte dipeptidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4 - Google Patents

Sulfonylerte dipeptidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4

Info

Publication number
NO20000452L
NO20000452L NO20000452A NO20000452A NO20000452L NO 20000452 L NO20000452 L NO 20000452L NO 20000452 A NO20000452 A NO 20000452A NO 20000452 A NO20000452 A NO 20000452A NO 20000452 L NO20000452 L NO 20000452L
Authority
NO
Norway
Prior art keywords
compounds
vla
leukocyte adhesion
sulfonylated
adhesion mediated
Prior art date
Application number
NO20000452A
Other languages
English (en)
Other versions
NO20000452D0 (no
Inventor
Eugene D Thorsett
Christopher M Semko
Michael A Pleiss
Anthony Kreft
Andrei W Konradi
Francine S Grant
Reinhardt Bernhard Baudy
Dimitrios Sarantakis
Original Assignee
Elan Pharm Inc
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, American Home Prod filed Critical Elan Pharm Inc
Publication of NO20000452D0 publication Critical patent/NO20000452D0/no
Publication of NO20000452L publication Critical patent/NO20000452L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det er beskrevet forbindelser som binder VLA-4. Noen av disse forbindelsene kan også inhibere leukocytt-adhesjon og, spesielt, leukocytt- adhesjon mediert av VLA-4. Slike forbindelser er nyttige for behandling av inflammatoriske sykdommer i en pattedyrpasient, for eksempel et menneske, så som astma, Alzheimer's sykdom, aterosklerose, AIDS demens, diabetes, inflammatorisk tarmsykdom, leddgikt, vevstransplantasjon, tumormetastase og myokardial ischemi. Forbindelsene kan også bli administrert for behandling av inflammatoriske hjernesykdommer så som multippel sklerose.
NO20000452A 1997-07-31 2000-01-28 Sulfonylerte dipeptidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4 NO20000452L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90442397A 1997-07-31 1997-07-31
PCT/US1998/016070 WO1999006437A1 (en) 1997-07-31 1998-07-31 Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
NO20000452D0 NO20000452D0 (no) 2000-01-28
NO20000452L true NO20000452L (no) 2000-03-27

Family

ID=25419137

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000452A NO20000452L (no) 1997-07-31 2000-01-28 Sulfonylerte dipeptidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4

Country Status (12)

Country Link
EP (1) EP0994896A1 (no)
JP (1) JP2001512139A (no)
KR (1) KR20010022405A (no)
CN (1) CN1265672A (no)
AU (1) AU8823498A (no)
BR (1) BR9811594A (no)
CA (1) CA2290748A1 (no)
HU (1) HUP0003921A3 (no)
IL (1) IL133637A0 (no)
NO (1) NO20000452L (no)
PL (1) PL338457A1 (no)
WO (1) WO1999006437A1 (no)

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US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
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CA2417059A1 (en) 2000-08-02 2002-02-07 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
BRPI0113331B8 (pt) 2000-08-18 2021-05-25 Ajinomoto Kk derivados de fenilalanina ou seus sais parmaceuticamente aceitáveis, antagonista de integrina alfa 4, agente terapêutico ou agente preventivo para doenças inflamatórias, e, composição farmacêutica
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Also Published As

Publication number Publication date
CN1265672A (zh) 2000-09-06
CA2290748A1 (en) 1999-02-11
HUP0003921A3 (en) 2001-03-28
KR20010022405A (ko) 2001-03-15
BR9811594A (pt) 2000-09-05
EP0994896A1 (en) 2000-04-26
WO1999006437A1 (en) 1999-02-11
PL338457A1 (en) 2000-11-06
HUP0003921A2 (hu) 2001-02-28
JP2001512139A (ja) 2001-08-21
NO20000452D0 (no) 2000-01-28
AU8823498A (en) 1999-02-22
IL133637A0 (en) 2001-04-30

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