NO20000452D0 - Sulfonylerte dipeptidforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4 - Google Patents

Sulfonylerte dipeptidforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4

Info

Publication number
NO20000452D0
NO20000452D0 NO20000452A NO20000452A NO20000452D0 NO 20000452 D0 NO20000452 D0 NO 20000452D0 NO 20000452 A NO20000452 A NO 20000452A NO 20000452 A NO20000452 A NO 20000452A NO 20000452 D0 NO20000452 D0 NO 20000452D0
Authority
NO
Norway
Prior art keywords
sulfonylated
vla
leukocyte adhesion
adhesion mediated
inhibit leukocyte
Prior art date
Application number
NO20000452A
Other languages
English (en)
Other versions
NO20000452L (no
Inventor
Eugene D Thorsett
Christopher M Semko
Michael A Pleiss
Anthony Kreft
Andrei W Konradi
Francine S Grant
Reinhardt Bernhard Baudy
Dimitrios Sarantakis
Original Assignee
Elan Pharm Inc
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, American Home Prod filed Critical Elan Pharm Inc
Publication of NO20000452D0 publication Critical patent/NO20000452D0/no
Publication of NO20000452L publication Critical patent/NO20000452L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO20000452A 1997-07-31 2000-01-28 Sulfonylerte dipeptidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4 NO20000452L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90442397A 1997-07-31 1997-07-31
PCT/US1998/016070 WO1999006437A1 (en) 1997-07-31 1998-07-31 Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
NO20000452D0 true NO20000452D0 (no) 2000-01-28
NO20000452L NO20000452L (no) 2000-03-27

Family

ID=25419137

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000452A NO20000452L (no) 1997-07-31 2000-01-28 Sulfonylerte dipeptidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4

Country Status (12)

Country Link
EP (1) EP0994896A1 (no)
JP (1) JP2001512139A (no)
KR (1) KR20010022405A (no)
CN (1) CN1265672A (no)
AU (1) AU8823498A (no)
BR (1) BR9811594A (no)
CA (1) CA2290748A1 (no)
HU (1) HUP0003921A3 (no)
IL (1) IL133637A0 (no)
NO (1) NO20000452L (no)
PL (1) PL338457A1 (no)
WO (1) WO1999006437A1 (no)

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US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
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US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
AU2018301A (en) 1999-12-28 2001-07-24 Pfizer Products Inc. Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
AU2001262089A1 (en) * 2000-03-14 2001-09-24 Novartis Ag Alpha4beta1 and alpha4beta7 integrin inhibitors
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US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
AU2001267753A1 (en) 2000-07-07 2002-01-21 Celltech R And D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
JP2004505110A (ja) 2000-08-02 2004-02-19 セルテック　アール　アンド　ディ　リミテッド ３位置換イソキノリン−１−イル誘導体
AU7874001A (en) 2000-08-18 2002-03-04 Ajinomoto Kk Novel phenylalanine derivatives
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
US6607735B2 (en) 2000-12-21 2003-08-19 Johnson & Johnson Consumer Companies, Inc. Method for reducing the appearance of dark circles under the eyes
US6559174B2 (en) 2001-03-20 2003-05-06 Merck & Co., Inc. N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
US6855708B2 (en) 2001-03-20 2005-02-15 Merck & Co., Inc. N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors
JP2004526733A (ja) 2001-03-20 2004-09-02 メルク　エンド　カムパニー　インコーポレーテッド 強力な細胞接着阻害剤としての置換ｎ−アリールスルホニル−プロリン誘導体
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JP4947482B2 (ja) * 2003-11-14 2012-06-06 味の素株式会社 フェニルアラニン誘導体の徐放性経口投与製剤
CN101448512B (zh) * 2005-12-14 2015-11-25 Ambrx公司 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及非天然氨基酸和多肽的用途
AU2008219007A1 (en) 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
AU2009234253C1 (en) 2008-04-11 2015-05-07 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
PT2713722T (pt) 2011-05-31 2017-06-27 Receptos Llc Novos estabilizadores e moduladores do receptor glp-1
KR20140107340A (ko) * 2011-12-12 2014-09-04 레셉토스, 인코포레이티드 당뇨병과 같은 치료를 위한 glp-1 수용체 조절제로서 작용하는 4 개의 사이클을 포함하는 카르복실산 유도체
BR112015031040A8 (pt) * 2013-06-11 2018-01-02 Receptos Inc Novos moduladores do receptor de glp-1
MX2017000972A (es) 2014-07-25 2017-07-27 Celgene Int Ii Sarl Nuevos moduladores del receptor de peptido similar a glucagon 1 (glp-1).
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US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
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BR112021007213A2 (pt) 2018-10-30 2021-08-10 Gilead Sciences, Inc. derivados de quinolina como inibidores de integrina alfa4beta7
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
AU2020329207B2 (en) 2019-08-14 2024-02-29 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin

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Also Published As

Publication number Publication date
HUP0003921A3 (en) 2001-03-28
CN1265672A (zh) 2000-09-06
IL133637A0 (en) 2001-04-30
NO20000452L (no) 2000-03-27
PL338457A1 (en) 2000-11-06
AU8823498A (en) 1999-02-22
WO1999006437A1 (en) 1999-02-11
EP0994896A1 (en) 2000-04-26
HUP0003921A2 (hu) 2001-02-28
CA2290748A1 (en) 1999-02-11
KR20010022405A (ko) 2001-03-15
BR9811594A (pt) 2000-09-05
JP2001512139A (ja) 2001-08-21

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