NO20000452L - Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4 - Google Patents
Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4Info
- Publication number
- NO20000452L NO20000452L NO20000452A NO20000452A NO20000452L NO 20000452 L NO20000452 L NO 20000452L NO 20000452 A NO20000452 A NO 20000452A NO 20000452 A NO20000452 A NO 20000452A NO 20000452 L NO20000452 L NO 20000452L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- vla
- leukocyte adhesion
- sulfonylated
- adhesion mediated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Det er beskrevet forbindelser som binder VLA-4. Noen av disse forbindelsene kan også inhibere leukocytt-adhesjon og, spesielt, leukocytt- adhesjon mediert av VLA-4. Slike forbindelser er nyttige for behandling av inflammatoriske sykdommer i en pattedyrpasient, for eksempel et menneske, så som astma, Alzheimer's sykdom, aterosklerose, AIDS demens, diabetes, inflammatorisk tarmsykdom, leddgikt, vevstransplantasjon, tumormetastase og myokardial ischemi. Forbindelsene kan også bli administrert for behandling av inflammatoriske hjernesykdommer så som multippel sklerose.Compounds that bind VLA-4 are described. Some of these compounds may also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful for the treatment of inflammatory diseases in a mammalian patient, such as a human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds may also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90442397A | 1997-07-31 | 1997-07-31 | |
PCT/US1998/016070 WO1999006437A1 (en) | 1997-07-31 | 1998-07-31 | Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20000452D0 NO20000452D0 (en) | 2000-01-28 |
NO20000452L true NO20000452L (en) | 2000-03-27 |
Family
ID=25419137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20000452A NO20000452L (en) | 1997-07-31 | 2000-01-28 | Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0994896A1 (en) |
JP (1) | JP2001512139A (en) |
KR (1) | KR20010022405A (en) |
CN (1) | CN1265672A (en) |
AU (1) | AU8823498A (en) |
BR (1) | BR9811594A (en) |
CA (1) | CA2290748A1 (en) |
HU (1) | HUP0003921A3 (en) |
IL (1) | IL133637A0 (en) |
NO (1) | NO20000452L (en) |
PL (1) | PL338457A1 (en) |
WO (1) | WO1999006437A1 (en) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
DE69820614T2 (en) * | 1997-05-30 | 2004-09-30 | Celltech Therapeutics Ltd., Slough | ANTI-INFLAMMATORY TYROSINE DERIVATIVES |
DE69818049T2 (en) | 1997-06-23 | 2004-07-15 | Tanabe Seiyaku Co., Ltd. | INHIBITORS OF ALPHA4-BETA1 MEDIATED CELL ADHESION |
EP1034164B1 (en) * | 1997-11-24 | 2004-05-19 | Merck & Co., Inc. | Substituted beta-alanine derivatives as cell adhesion inhibitors |
US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
US6197794B1 (en) * | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
JP2002504534A (en) | 1998-02-26 | 2002-02-12 | セルテック・セラピューティクス・リミテッド | Phenylalanine derivatives as inhibitors of α4 integrin |
US6521626B1 (en) * | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
US7396526B1 (en) | 1998-11-12 | 2008-07-08 | Johnson & Johnson Consumer Companies, Inc. | Skin care composition |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
CA2362831C (en) * | 1999-02-18 | 2008-10-07 | F. Hoffmann-La Roche Ag | Thioamide derivatives |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
GEP20053477B (en) * | 1999-08-13 | 2005-03-25 | Biogen Inc | Cell Adhesion Inhibitors and Pharmaceutical Compositions Containing Them |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
BR0016818A (en) | 1999-12-28 | 2002-10-01 | Pfizer Prod Inc | Non-peptidyl inhibitors of vla-4-dependent cell adhesion useful in the treatment of inflammatory, autoimmune and respiratory diseases |
AU2001262089A1 (en) * | 2000-03-14 | 2001-09-24 | Novartis Ag | Alpha4beta1 and alpha4beta7 integrin inhibitors |
ATE375330T1 (en) | 2000-04-17 | 2007-10-15 | Ucb Pharma Sa | ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
AU2001267753A1 (en) | 2000-07-07 | 2002-01-21 | Celltech R And D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
WO2002010136A1 (en) | 2000-08-02 | 2002-02-07 | Celltech R & D Limited | 3-substituted isoquinolin-1-yl derivatives |
IL154350A0 (en) * | 2000-08-18 | 2003-09-17 | Ajinomoto Kk | New phenylalanine derivatives |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
US6607735B2 (en) | 2000-12-21 | 2003-08-19 | Johnson & Johnson Consumer Companies, Inc. | Method for reducing the appearance of dark circles under the eyes |
US6855708B2 (en) | 2001-03-20 | 2005-02-15 | Merck & Co., Inc. | N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors |
US6559174B2 (en) | 2001-03-20 | 2003-05-06 | Merck & Co., Inc. | N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors |
JP2004526733A (en) | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors |
ATE464299T1 (en) | 2002-02-20 | 2010-04-15 | Ajinomoto Kk | NEW PHENYLALANINE DERIVATIVE |
EP1592386A4 (en) | 2003-01-24 | 2007-06-13 | Elan Pharm Inc | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
NZ544367A (en) * | 2003-06-25 | 2009-12-24 | Elan Pharm Inc | Combination therapy involving methotrexate for treating rheumatoid arthritis |
WO2005046697A1 (en) * | 2003-11-14 | 2005-05-26 | Ajinomoto Co., Inc. | Sustained-release phenylalanine derivative preparation for oral administration |
EP1683524B1 (en) * | 2003-11-14 | 2011-01-19 | Ajinomoto Co., Inc. | Solid dispersion or medicinal solid dispersion preparation of phenylalanine derivative |
ES2529065T3 (en) * | 2005-12-14 | 2015-02-16 | Ambrx, Inc. | Compositions they contain, procedures that involve and uses of unnatural amino acids and polypeptides |
EP2124996A4 (en) | 2007-02-20 | 2010-03-24 | Merrimack Pharmaceuticals Inc | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
EP2288715B1 (en) | 2008-04-11 | 2014-09-24 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
WO2012166951A1 (en) | 2011-05-31 | 2012-12-06 | Receptos, Inc. | Novel glp-1 receptor stabilizers and modulators |
CN104080767A (en) * | 2011-12-12 | 2014-10-01 | 瑞塞普托斯公司 | Novel GLP-1 receptor modulators |
MX370666B (en) | 2013-06-11 | 2019-12-19 | Celgene Int Ii Sarl | Novel glp-1 receptor modulators. |
ES2819534T3 (en) | 2014-07-25 | 2021-04-16 | Receptos Llc | Pyrimidine derivatives as GLP-1 receptor modulators |
WO2016094729A1 (en) | 2014-12-10 | 2016-06-16 | Celgene International Ii Sarl | Glp-1 receptor modulators |
US9969769B2 (en) | 2014-12-19 | 2018-05-15 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
US10308677B2 (en) | 2014-12-19 | 2019-06-04 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
WO2020092383A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
US11116760B2 (en) | 2018-10-30 | 2021-09-14 | Gilead Sciences, Inc. | Quinoline derivatives |
EP3873900A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2679903B1 (en) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | DERIVATIVES OF N-SULFONYL INDOLINE CARRYING AN AMIDIC FUNCTION, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
JPH04154732A (en) * | 1990-10-18 | 1992-05-27 | Nippon Kayaku Co Ltd | Optical resolution method |
WO1994007815A2 (en) * | 1992-09-25 | 1994-04-14 | Abbott Laboratories | Small peptide anaphylatoxin receptor ligands |
US5648368A (en) * | 1992-12-01 | 1997-07-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
JPH0873422A (en) * | 1994-09-07 | 1996-03-19 | Kdk Corp | New amino acid ester and method for detecting leukocyte, esterase or protease |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
-
1998
- 1998-07-31 BR BR9811594-4A patent/BR9811594A/en not_active IP Right Cessation
- 1998-07-31 AU AU88234/98A patent/AU8823498A/en not_active Abandoned
- 1998-07-31 WO PCT/US1998/016070 patent/WO1999006437A1/en not_active Application Discontinuation
- 1998-07-31 EP EP98939871A patent/EP0994896A1/en not_active Withdrawn
- 1998-07-31 JP JP2000505192A patent/JP2001512139A/en not_active Withdrawn
- 1998-07-31 CA CA002290748A patent/CA2290748A1/en not_active Abandoned
- 1998-07-31 PL PL98338457A patent/PL338457A1/en not_active Application Discontinuation
- 1998-07-31 HU HU0003921A patent/HUP0003921A3/en unknown
- 1998-07-31 IL IL13363798A patent/IL133637A0/en unknown
- 1998-07-31 KR KR1020007000985A patent/KR20010022405A/en not_active Application Discontinuation
- 1998-07-31 CN CN98807721A patent/CN1265672A/en active Pending
-
2000
- 2000-01-28 NO NO20000452A patent/NO20000452L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999006437A1 (en) | 1999-02-11 |
JP2001512139A (en) | 2001-08-21 |
CN1265672A (en) | 2000-09-06 |
HUP0003921A2 (en) | 2001-02-28 |
AU8823498A (en) | 1999-02-22 |
BR9811594A (en) | 2000-09-05 |
PL338457A1 (en) | 2000-11-06 |
HUP0003921A3 (en) | 2001-03-28 |
IL133637A0 (en) | 2001-04-30 |
CA2290748A1 (en) | 1999-02-11 |
NO20000452D0 (en) | 2000-01-28 |
EP0994896A1 (en) | 2000-04-26 |
KR20010022405A (en) | 2001-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20000452L (en) | Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000412L (en) | Dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000451L (en) | Compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000414L (en) | Benzyl compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000413L (en) | Carbamyloxy compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000410L (en) | Dipeptide and related compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000411L (en) | 4-Amino-phenylalamine compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
NO20000450L (en) | Substituted phenylalanine compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
MXPA01007335A (en) | Acyl derivatives which treat vla-4 related disorders. | |
NO20070216L (en) | Multivalent VLA-1 antagonists containing polymer halves | |
NO20043900L (en) | Heterocyclic compounds that inhibit leukocyte adhesion mediated by integrins | |
NO20082002L (en) | Pyrimidinylamide compounds that inhibit leukocyte adhesion mediated by VLA-4 | |
WO2000043354A3 (en) | Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4 | |
EA200401561A1 (en) | HETEROARRYLIC COMPOUNDS THAT INHIBIT MEDIATED ГР4-INTEGRINES leukocyte adhesion | |
WO2002008203A3 (en) | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by vla-4 | |
ZA200803016B (en) | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 | |
AU3246600A (en) | Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 receptor antagonists | |
WO2000043371A3 (en) | Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by vla-4 | |
WO2002008201A3 (en) | Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by vla-4 | |
WO2000043413A3 (en) | Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by vla-4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |