BR0007663A - Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4 - Google Patents

Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4

Info

Publication number
BR0007663A
BR0007663A BR0007663-5A BR0007663A BR0007663A BR 0007663 A BR0007663 A BR 0007663A BR 0007663 A BR0007663 A BR 0007663A BR 0007663 A BR0007663 A BR 0007663A
Authority
BR
Brazil
Prior art keywords
vla
compounds
treatment
diseases related
acyl derivatives
Prior art date
Application number
BR0007663-5A
Other languages
English (en)
Inventor
Andrei W Konradi
Michael A Pleiss
Eugene D Thorsett
Susan Ashwell
Gregory S Welmaker
Anthony Kreft
Dimitrios Sarantakis
Darren B Dressen
Francine S Grant
Christopher Semko
Ying-Zi Xu
Original Assignee
Elan Pharm Inc
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, American Home Prod filed Critical Elan Pharm Inc
Priority claimed from PCT/US2000/001686 external-priority patent/WO2000043372A1/en
Publication of BR0007663A publication Critical patent/BR0007663A/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/425—Thiazoles
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Abstract

"DERIVADOS DE ACILA PARA USO NO TRATAMENTO DE DOENçAS RELACIONADAS COM O VLA-4". São mostrados compostos, tais como Ia e Ib, os quais se ligam a VLA-4. Alguns desses compostos também inibem a adesão de leucócito e, em particular, a adesão de leucócito mediada por VLA-4. Esses compostos são úteis no tratamento de doenças inflamatórias em um paciente mamífero, por exemplo, humano, tais como asma, mal de Alzheimer, ateroscrelose, demência da AIDS, diabetes, doença inflamatória do intestino, artrite reumatóide, transplante de tecido, metástase de tumor e isquemia do miocárdio. Os compostos também podem ser administrados para o tratamento de doenças inflamatórias do cérebro, tais como esclerose múltipla.
BR0007663-5A 1999-01-22 2000-01-21 Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4 BR0007663A (pt)

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US11692399P 1999-01-22 1999-01-22
US16099999P 1999-10-21 1999-10-21
PCT/US2000/001686 WO2000043372A1 (en) 1999-01-22 2000-01-21 Acyl derivatives which treat vla-4 related disorders

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WO2005111017A1 (en) * 2004-05-07 2005-11-24 Janssen Pharmaceutica, N.V. Triazine compounds as inhibitors of bacterial type iii protein secretion systems
CA2573245C (en) * 2004-07-08 2013-10-01 Elan Pharmaceuticals, Inc. Multivalent vla-4 antagonists comprising polymer moieties
GB0416699D0 (en) * 2004-07-27 2004-09-01 Prometic Biosciences Ltd Prion protein ligands and methods of use
EP1881982B1 (en) * 2005-05-20 2013-11-20 Elan Pharmaceuticals Inc. Imidazolone phenylalanine derivatives as vla-4 antagonists
EP1899308B1 (en) * 2005-06-10 2012-11-07 ProMetic BioSciences Limited Triazines as protein binding ligands
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EP1144384A1 (en) 2001-10-17
JP2002535314A (ja) 2002-10-22
CN1220683C (zh) 2005-09-28
DK1144388T3 (da) 2010-05-25
US6479492B1 (en) 2002-11-12
ATE455106T1 (de) 2010-01-15
HK1046132B (zh) 2006-05-04
CA2359113A1 (en) 2000-07-27
KR20020002374A (ko) 2002-01-09
MXPA01007335A (es) 2004-06-07
ES2339738T3 (es) 2010-05-25
CZ20012361A3 (cs) 2001-12-12
US20040147512A1 (en) 2004-07-29
US7049306B2 (en) 2006-05-23
US20030125324A1 (en) 2003-07-03
US7741328B2 (en) 2010-06-22
US7968547B2 (en) 2011-06-28
EA006301B1 (ru) 2005-10-27
US7378529B2 (en) 2008-05-27
NO20013600D0 (no) 2001-07-20

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