BRPI0513143A - antagonistas de vla-4 multivalentes compreendendo porções poliméricas - Google Patents

antagonistas de vla-4 multivalentes compreendendo porções poliméricas

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Publication number
BRPI0513143A
BRPI0513143A BRPI0513143-0A BRPI0513143A BRPI0513143A BR PI0513143 A BRPI0513143 A BR PI0513143A BR PI0513143 A BRPI0513143 A BR PI0513143A BR PI0513143 A BRPI0513143 A BR PI0513143A
Authority
BR
Brazil
Prior art keywords
vla
conjugates
multivalent
antagonists
inflammatory
Prior art date
Application number
BRPI0513143-0A
Other languages
English (en)
Inventor
Andrei Konradi
Michael A Pleiss
Chistopher M Semko
Theodore Yednock
Jenifer L Smith
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of BRPI0513143A publication Critical patent/BRPI0513143A/pt

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

ANTAGONISTAS DE VLA-4 MULTIVALENTES COMPREENDENDO PORçõES POLIMéRICAS. A presente invenção refere-se a divulgados conjugados, os quais se ligam à VLA-4. Alguns desses conjugados também inibem a adesão de leucócitos e, em particular, a adesão de leucócitos mediada por VLA-4. Tais conjugados são usados no tratamento de doenças inflamatórias em um paciente mamífero, por exemplo, um ser humano, tais como asma, mal de Alzheimer, aterosclerose, demência pela AIDS, diabetes, doença inflamatória do intestino, artrite reumatóide, transplante de tecido, metástase de tumor e isquemia do miocárdio. Os conjugados podem também ser administrados para o tratamento de doenças inflamatórias do cérebro, tal como esclerose múltipla.
BRPI0513143-0A 2004-07-08 2005-07-08 antagonistas de vla-4 multivalentes compreendendo porções poliméricas BRPI0513143A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58697504P 2004-07-08 2004-07-08
PCT/US2005/024369 WO2006010054A2 (en) 2004-07-08 2005-07-08 Multivalent vla-4 antagonists comprising polyethylene glycol moieties

Publications (1)

Publication Number Publication Date
BRPI0513143A true BRPI0513143A (pt) 2008-04-29

Family

ID=35501261

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513143-0A BRPI0513143A (pt) 2004-07-08 2005-07-08 antagonistas de vla-4 multivalentes compreendendo porções poliméricas

Country Status (20)

Country Link
US (4) US7794700B2 (pt)
EP (4) EP2298356A3 (pt)
JP (1) JP2008505927A (pt)
KR (1) KR101273614B1 (pt)
CN (1) CN101035563B (pt)
AR (1) AR050425A1 (pt)
AU (1) AU2005265316B2 (pt)
BR (1) BRPI0513143A (pt)
CA (1) CA2573245C (pt)
EA (1) EA012433B1 (pt)
EC (1) ECSP077231A (pt)
HK (1) HK1111674A1 (pt)
IL (1) IL180558A0 (pt)
MA (1) MA28786B1 (pt)
MX (1) MX2007000228A (pt)
NO (1) NO20070216L (pt)
NZ (1) NZ588839A (pt)
TW (1) TWI418346B (pt)
WO (1) WO2006010054A2 (pt)
ZA (1) ZA200700238B (pt)

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US20110002876A1 (en) 2011-01-06
US20130338164A1 (en) 2013-12-19
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ECSP077231A (es) 2007-03-29
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