ES2197003B1 - Nuevos compuestos antagonistas de integrinas alfa. - Google Patents
Nuevos compuestos antagonistas de integrinas alfa.Info
- Publication number
- ES2197003B1 ES2197003B1 ES200200805A ES200200805A ES2197003B1 ES 2197003 B1 ES2197003 B1 ES 2197003B1 ES 200200805 A ES200200805 A ES 200200805A ES 200200805 A ES200200805 A ES 200200805A ES 2197003 B1 ES2197003 B1 ES 2197003B1
- Authority
- ES
- Spain
- Prior art keywords
- integrinas
- alfa
- antagonist compounds
- new
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Nuevos compuestos antagonistas de integrinas alfa. La presente invención se refiere a nuevos compuestos de fórmula I y sus sales, solvatos y prodrogas, en donde los significados de los distintos sustituyentes son como se indican en la parte descriptiva. Estos compuestos son útiles como antagonistas de integrinas alfa.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200805A ES2197003B1 (es) | 2002-04-08 | 2002-04-08 | Nuevos compuestos antagonistas de integrinas alfa. |
US10/510,626 US20050143391A1 (en) | 2002-04-08 | 2003-04-08 | Heterocyclic amides with alpha-4 integrin antagonist activity |
JP2003582179A JP2006506320A (ja) | 2002-04-08 | 2003-04-08 | α4インテグリン拮抗薬活性を有する新規化合物 |
PCT/EP2003/003635 WO2003084984A1 (en) | 2002-04-08 | 2003-04-08 | Heterocyclic amides with alpha-4 integrin antagonist activity |
AU2003233958A AU2003233958A1 (en) | 2002-04-08 | 2003-04-08 | Heterocyclic amides with alpha-4 integrin antagonist activity |
ARP030101227A AR039401A1 (es) | 2002-04-08 | 2003-04-08 | Un compuesto antagonista de integrinas alfa 4 y un procedimiento para preparar el mismo |
CA002477943A CA2477943A1 (en) | 2002-04-08 | 2003-04-08 | Heterocyclic amides with alpha-4 integrin antagonist activity |
EP03727281A EP1495044A1 (en) | 2002-04-08 | 2003-04-08 | Heterocyclic amides with alpha-4 integrin antagonist activity |
KR10-2004-7015916A KR20040094912A (ko) | 2002-04-08 | 2003-04-08 | 알파-4 인테그린 안타고니스트 활성을 갖는 헤테로시클릭아미드 |
BR0309120-1A BR0309120A (pt) | 2002-04-08 | 2003-04-08 | Compostos com atividade antagonista de integrina alfa4 |
MXPA04008990A MXPA04008990A (es) | 2002-04-08 | 2003-04-08 | Amidas heterociclicas con actividad antagonista de (4 integrinas. |
NO20044330A NO20044330L (no) | 2002-04-08 | 2004-10-12 | Heterosykliske amider med alfa-4 intergrin-antagonistaktivitet |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200805A ES2197003B1 (es) | 2002-04-08 | 2002-04-08 | Nuevos compuestos antagonistas de integrinas alfa. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2197003A1 ES2197003A1 (es) | 2003-12-16 |
ES2197003B1 true ES2197003B1 (es) | 2005-03-16 |
Family
ID=28686084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200200805A Expired - Fee Related ES2197003B1 (es) | 2002-04-08 | 2002-04-08 | Nuevos compuestos antagonistas de integrinas alfa. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20050143391A1 (es) |
EP (1) | EP1495044A1 (es) |
JP (1) | JP2006506320A (es) |
KR (1) | KR20040094912A (es) |
AR (1) | AR039401A1 (es) |
AU (1) | AU2003233958A1 (es) |
BR (1) | BR0309120A (es) |
CA (1) | CA2477943A1 (es) |
ES (1) | ES2197003B1 (es) |
MX (1) | MXPA04008990A (es) |
NO (1) | NO20044330L (es) |
WO (1) | WO2003084984A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101273614B1 (ko) | 2004-07-08 | 2013-06-12 | 엘란 파마슈티칼스, 인크. | 중합체 부분을 포함하는 다가 vla―4 길항제 |
CA2591922A1 (en) * | 2004-12-24 | 2006-06-29 | Prosidion Limited | G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes |
WO2006127584A1 (en) | 2005-05-20 | 2006-11-30 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as vla-4 antagonists |
US8987306B2 (en) | 2005-06-07 | 2015-03-24 | The Trustees Of The University Of Pennsylvania | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold |
WO2006133338A1 (en) * | 2005-06-07 | 2006-12-14 | The Trustees Of The University Of Pennesylvania | INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN |
AU2006264651A1 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | G-protein coupled receptor agonists |
AR059826A1 (es) * | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
MX2010006259A (es) * | 2007-12-05 | 2010-08-23 | Astrazeneca Ab | Piperazinas como agentes antiobesidad. |
AU2008333183A1 (en) | 2007-12-05 | 2009-06-11 | Astrazeneca Ab (Publ) | Piperazine derivatives and their use as leptin receptor modulators |
US20090203695A1 (en) * | 2007-12-05 | 2009-08-13 | Biovitrum Ab | Compounds IV |
CA2720164A1 (en) * | 2008-03-31 | 2009-10-08 | Teva Pharmaceutical Industries Ltd. | Processes for preparing sunitinib and salts thereof |
EP3199551A3 (en) | 2009-07-31 | 2017-10-18 | E. R. Squibb & Sons, L.L.C. | Fully human antibodies to btla |
US8691227B2 (en) | 2009-12-17 | 2014-04-08 | Merck Sharp & Dohme Corp. | Methods of treating multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease using agonists antibodies to PILR-α |
CA3019130A1 (en) * | 2016-04-01 | 2017-10-05 | The Regents Of The University Of California | Inhibitors of integrin alpha 5 beta 1 and methods of use |
WO2018085552A1 (en) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002512625A (ja) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
CA2290749A1 (en) * | 1997-07-31 | 1999-02-11 | Elan Pharmaceuticals, Inc. | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4 |
CA2380817A1 (en) * | 1999-08-13 | 2001-02-22 | Biogen, Inc. | Cell adhesion inhibitors |
EP1253923A1 (en) * | 2000-01-28 | 2002-11-06 | Biogen, Inc. | Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses |
-
2002
- 2002-04-08 ES ES200200805A patent/ES2197003B1/es not_active Expired - Fee Related
-
2003
- 2003-04-08 AU AU2003233958A patent/AU2003233958A1/en not_active Abandoned
- 2003-04-08 MX MXPA04008990A patent/MXPA04008990A/es not_active Application Discontinuation
- 2003-04-08 CA CA002477943A patent/CA2477943A1/en not_active Abandoned
- 2003-04-08 AR ARP030101227A patent/AR039401A1/es not_active Application Discontinuation
- 2003-04-08 BR BR0309120-1A patent/BR0309120A/pt not_active IP Right Cessation
- 2003-04-08 KR KR10-2004-7015916A patent/KR20040094912A/ko not_active Application Discontinuation
- 2003-04-08 US US10/510,626 patent/US20050143391A1/en not_active Abandoned
- 2003-04-08 EP EP03727281A patent/EP1495044A1/en not_active Withdrawn
- 2003-04-08 WO PCT/EP2003/003635 patent/WO2003084984A1/en active Application Filing
- 2003-04-08 JP JP2003582179A patent/JP2006506320A/ja not_active Withdrawn
-
2004
- 2004-10-12 NO NO20044330A patent/NO20044330L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2197003A1 (es) | 2003-12-16 |
JP2006506320A (ja) | 2006-02-23 |
WO2003084984A1 (en) | 2003-10-16 |
BR0309120A (pt) | 2005-01-11 |
NO20044330L (no) | 2004-10-28 |
MXPA04008990A (es) | 2005-06-20 |
US20050143391A1 (en) | 2005-06-30 |
WO2003084984A8 (en) | 2003-12-11 |
AR039401A1 (es) | 2005-02-16 |
EP1495044A1 (en) | 2005-01-12 |
AU2003233958A1 (en) | 2003-10-20 |
KR20040094912A (ko) | 2004-11-10 |
CA2477943A1 (en) | 2003-10-16 |
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