ZA986827B - Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. - Google Patents
Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.Info
- Publication number
- ZA986827B ZA986827B ZA9806827A ZA986827A ZA986827B ZA 986827 B ZA986827 B ZA 986827B ZA 9806827 A ZA9806827 A ZA 9806827A ZA 986827 A ZA986827 A ZA 986827A ZA 986827 B ZA986827 B ZA 986827B
- Authority
- ZA
- South Africa
- Prior art keywords
- vla
- type compounds
- leukocyte adhesion
- adhesion mediated
- substituted phenylalanine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92039497A | 1997-07-31 | 1997-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA986827B true ZA986827B (en) | 2000-05-02 |
Family
ID=25443662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9806827A ZA986827B (en) | 1997-07-31 | 1998-07-30 | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1001972A1 (en) |
JP (1) | JP2001512134A (en) |
KR (1) | KR20010022411A (en) |
CN (1) | CN1133648C (en) |
AR (1) | AR013384A1 (en) |
AU (1) | AU756696B2 (en) |
BR (1) | BR9812114A (en) |
CA (1) | CA2290747A1 (en) |
HU (1) | HUP0004259A3 (en) |
IL (1) | IL133640A0 (en) |
NO (1) | NO20000450L (en) |
NZ (1) | NZ502582A (en) |
PL (1) | PL338423A1 (en) |
TW (1) | TW534910B (en) |
WO (1) | WO1999006431A1 (en) |
ZA (1) | ZA986827B (en) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291511B1 (en) | 1997-05-29 | 2001-09-18 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
ATE256699T1 (en) * | 1997-05-30 | 2004-01-15 | Celltech Therapeutics Ltd | ANTI-INFLAMMATORY TYROSINE DERIVATIVES |
JP2001517246A (en) | 1997-06-23 | 2001-10-02 | 田辺製薬株式会社 | α ▲ Lower 4 ▼ β ▲ Lower 1 ▼ Inhibitor of cell adhesion |
US6197794B1 (en) * | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
DE69919334T2 (en) | 1998-02-26 | 2005-08-04 | Celltech Therapeutics Ltd., Slough | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINEN |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
US7396526B1 (en) | 1998-11-12 | 2008-07-08 | Johnson & Johnson Consumer Companies, Inc. | Skin care composition |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
CA2359112A1 (en) | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by vla-4 |
AU773538B2 (en) | 1999-01-22 | 2004-05-27 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat VLA-4 related disorders |
US6436904B1 (en) | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
CN1185250C (en) * | 1999-01-25 | 2005-01-19 | 依兰制药公司 | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
PT1265606E (en) * | 1999-08-13 | 2007-01-31 | Biogen Idec Inc | Cell adhesion inhibitors |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
YU41202A (en) | 1999-12-28 | 2005-03-15 | Pfizer Products Inc. | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune and respiratory diseases |
ATE375330T1 (en) | 2000-04-17 | 2007-10-15 | Ucb Pharma Sa | ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
AU2001267753A1 (en) | 2000-07-07 | 2002-01-21 | Celltech R And D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
CA2417059A1 (en) | 2000-08-02 | 2002-02-07 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
WO2002016329A1 (en) | 2000-08-18 | 2002-02-28 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
US6607735B2 (en) | 2000-12-21 | 2003-08-19 | Johnson & Johnson Consumer Companies, Inc. | Method for reducing the appearance of dark circles under the eyes |
JP2004526733A (en) * | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors |
DE10127126A1 (en) * | 2001-06-05 | 2002-12-19 | Forschungszentrum Juelich Gmbh | New protected O-(2-substituted ethyl)-L-tyrosine derivatives, useful as intermediates for the positron emission tomography contrast agent O-(2-(18F)-fluoroethyl)-L-tyrosine |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
KR101260497B1 (en) * | 2003-01-24 | 2013-09-12 | 엘란 파마슈티칼스, 인크. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
AU2004251754A1 (en) * | 2003-06-25 | 2005-01-06 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
EP2615087A3 (en) | 2003-12-22 | 2013-08-07 | Ajinomoto Co., Inc. | Phenylalanine derivatives |
CA2714335A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
ES2525065T3 (en) | 2008-04-11 | 2014-12-17 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and their conjugates |
US8586607B2 (en) * | 2008-07-28 | 2013-11-19 | Syddansk Universitet | Compounds for the treatment of metabolic diseases |
US20170002077A1 (en) | 2014-03-13 | 2017-01-05 | Prothena Biosciences Limited | Combination treatment for multiple sclerosis |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
EP3873605A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
WO2020092383A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
KR20240015737A (en) | 2018-10-30 | 2024-02-05 | 길리애드 사이언시즈, 인코포레이티드 | Quinoline derivatives as alpha4beta7 integrin inhibitors |
US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737898B (en) * | 1972-11-24 | 1974-07-31 | Hoffmann La Roche | Peptides |
CA1102316A (en) * | 1975-12-09 | 1981-06-02 | Shosuke Okamoto | N su2 xx-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof |
AU1354292A (en) * | 1991-03-18 | 1992-10-21 | Pentapharm Ag | Parasubstituted phenylalanine derivates |
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
-
1998
- 1998-07-30 AU AU86611/98A patent/AU756696B2/en not_active Ceased
- 1998-07-30 ZA ZA9806827A patent/ZA986827B/en unknown
- 1998-07-30 CN CNB988077531A patent/CN1133648C/en not_active Expired - Fee Related
- 1998-07-30 WO PCT/US1998/015313 patent/WO1999006431A1/en not_active Application Discontinuation
- 1998-07-30 EP EP98937990A patent/EP1001972A1/en not_active Withdrawn
- 1998-07-30 PL PL98338423A patent/PL338423A1/en not_active IP Right Cessation
- 1998-07-30 NZ NZ502582A patent/NZ502582A/en unknown
- 1998-07-30 HU HU0004259A patent/HUP0004259A3/en unknown
- 1998-07-30 IL IL13364098A patent/IL133640A0/en unknown
- 1998-07-30 AR ARP980103778A patent/AR013384A1/en unknown
- 1998-07-30 KR KR1020007000991A patent/KR20010022411A/en not_active Application Discontinuation
- 1998-07-30 JP JP2000505186A patent/JP2001512134A/en not_active Withdrawn
- 1998-07-30 BR BR9812114-6A patent/BR9812114A/en not_active Application Discontinuation
- 1998-07-30 CA CA002290747A patent/CA2290747A1/en not_active Abandoned
- 1998-07-31 TW TW087112638A patent/TW534910B/en not_active IP Right Cessation
-
2000
- 2000-01-28 NO NO20000450A patent/NO20000450L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2290747A1 (en) | 1999-02-11 |
KR20010022411A (en) | 2001-03-15 |
JP2001512134A (en) | 2001-08-21 |
NO20000450L (en) | 2000-03-28 |
EP1001972A1 (en) | 2000-05-24 |
NZ502582A (en) | 2002-07-26 |
BR9812114A (en) | 2000-07-18 |
CN1133648C (en) | 2004-01-07 |
HUP0004259A2 (en) | 2001-04-28 |
HUP0004259A3 (en) | 2001-05-28 |
WO1999006431A1 (en) | 1999-02-11 |
PL338423A1 (en) | 2000-11-06 |
IL133640A0 (en) | 2001-04-30 |
NO20000450D0 (en) | 2000-01-28 |
AR013384A1 (en) | 2000-12-27 |
AU8661198A (en) | 1999-02-22 |
CN1265668A (en) | 2000-09-06 |
AU756696B2 (en) | 2003-01-23 |
TW534910B (en) | 2003-06-01 |
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