BRPI1015259A2 - antagonistas de piridinona de integrinas alfa-4 - Google Patents
antagonistas de piridinona de integrinas alfa-4Info
- Publication number
- BRPI1015259A2 BRPI1015259A2 BRPI1015259A BRPI1015259A BRPI1015259A2 BR PI1015259 A2 BRPI1015259 A2 BR PI1015259A2 BR PI1015259 A BRPI1015259 A BR PI1015259A BR PI1015259 A BRPI1015259 A BR PI1015259A BR PI1015259 A2 BRPI1015259 A2 BR PI1015259A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyridinone
- integrin
- antagonists
- alpha
- pyridinone antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17287609P | 2009-04-27 | 2009-04-27 | |
| PCT/US2010/032632 WO2010126914A1 (en) | 2009-04-27 | 2010-04-27 | Pyridinone antagonists of alpha-4 integrins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1015259A2 true BRPI1015259A2 (pt) | 2016-05-03 |
Family
ID=42235905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1015259A BRPI1015259A2 (pt) | 2009-04-27 | 2010-04-27 | antagonistas de piridinona de integrinas alfa-4 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8367836B2 (pt) |
| EP (1) | EP2424841A1 (pt) |
| JP (1) | JP2012525336A (pt) |
| CN (1) | CN102459179A (pt) |
| AU (1) | AU2010241742A1 (pt) |
| BR (1) | BRPI1015259A2 (pt) |
| CA (1) | CA2760151A1 (pt) |
| IL (1) | IL215956A0 (pt) |
| MX (1) | MX2011011326A (pt) |
| SG (2) | SG10201401836RA (pt) |
| WO (1) | WO2010126914A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| CN103201267B (zh) | 2010-07-29 | 2016-08-17 | 里格尔药品股份有限公司 | Ampk-激活性杂环化合物以及其使用方法 |
| KR101317656B1 (ko) * | 2011-06-30 | 2013-10-15 | 연세대학교 산학협력단 | 복제효소 인산화를 조절하는 신규 ｃ형 간염 예방 또는 치료용 조성물 |
| EP2562174A1 (de) * | 2011-08-24 | 2013-02-27 | Bayer Cropscience AG | Herbizid wirksame 6-Oxo-1,6-dihydropyrimidin-5-carboxamide und 2-Oxo-1,2-dihydropyridin-3-carboxamide |
| US8933103B2 (en) * | 2012-01-31 | 2015-01-13 | Daiichi Sankyo Company, Limited | Pyridone derivatives |
| MX2014013489A (es) * | 2012-05-09 | 2015-02-12 | Bayer Cropscience Ag | 5-halogenopirazolindanil carboxamidas. |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX2016012808A (es) | 2014-04-02 | 2017-01-05 | Intermune Inc | Piridinonas anti-fibroticas. |
| TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| WO2019200114A1 (en) * | 2018-04-12 | 2019-10-17 | Arbutus Biopharma Corporation | Methods for preparing substituted dihydroindene-4-carboxamide compounds |
| JP7214882B2 (ja) | 2018-10-30 | 2023-01-30 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリン阻害剤としてのイミダゾピリジン誘導体 |
| AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
| AU2019373245C1 (en) | 2018-10-30 | 2022-10-27 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4β7 integrin |
| MX2021010314A (es) * | 2019-02-28 | 2021-11-12 | Kezar Life Sciences | Derivados de tiazol como inhibidores de la secreción de proteínas. |
| US20220289679A1 (en) * | 2019-07-29 | 2022-09-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
| CN116745279A (zh) * | 2021-02-02 | 2023-09-12 | 株式会社Lg化学 | 作为蛋白激酶抑制剂的新型化合物 |
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| JP2009526761A (ja) * | 2006-01-30 | 2009-07-23 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環式チオフェン化合物および使用の方法 |
| EP1996559A1 (en) | 2006-02-27 | 2008-12-03 | Elan Pharmaceuticals Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| JP5642963B2 (ja) * | 2006-06-30 | 2014-12-17 | スネシス ファーマシューティカルズ，インコーポレイティド | ピリジノニルｐｄｋ１阻害剤 |
| WO2008084671A1 (ja) * | 2006-12-27 | 2008-07-17 | Shionogi & Co., Ltd. | １－置換－２－ピリドン－３－カルボン酸誘導体の製造方法 |
| EP2200990A1 (en) * | 2007-09-06 | 2010-06-30 | Schering Corporation | Gamma secretase modulators |
-
2010
- 2010-04-27 MX MX2011011326A patent/MX2011011326A/es active IP Right Grant
- 2010-04-27 SG SG10201401836RA patent/SG10201401836RA/en unknown
- 2010-04-27 JP JP2012507475A patent/JP2012525336A/ja active Pending
- 2010-04-27 SG SG2011078409A patent/SG175355A1/en unknown
- 2010-04-27 AU AU2010241742A patent/AU2010241742A1/en not_active Abandoned
- 2010-04-27 CA CA2760151A patent/CA2760151A1/en not_active Abandoned
- 2010-04-27 CN CN2010800273757A patent/CN102459179A/zh active Pending
- 2010-04-27 WO PCT/US2010/032632 patent/WO2010126914A1/en active Application Filing
- 2010-04-27 US US12/768,680 patent/US8367836B2/en not_active Expired - Fee Related
- 2010-04-27 BR BRPI1015259A patent/BRPI1015259A2/pt not_active IP Right Cessation
- 2010-04-27 EP EP10719684A patent/EP2424841A1/en not_active Withdrawn
-
2011
- 2011-10-26 IL IL215956A patent/IL215956A0/en unknown
-
2012
- 2012-12-28 US US13/730,522 patent/US20130252957A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110009407A1 (en) | 2011-01-13 |
| CA2760151A1 (en) | 2010-11-04 |
| SG10201401836RA (en) | 2014-10-30 |
| US20130252957A1 (en) | 2013-09-26 |
| EP2424841A1 (en) | 2012-03-07 |
| AU2010241742A1 (en) | 2011-11-17 |
| SG175355A1 (en) | 2011-12-29 |
| IL215956A0 (en) | 2012-01-31 |
| CN102459179A (zh) | 2012-05-16 |
| WO2010126914A1 (en) | 2010-11-04 |
| US8367836B2 (en) | 2013-02-05 |
| MX2011011326A (es) | 2012-02-13 |
| JP2012525336A (ja) | 2012-10-22 |
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