BRPI1015259A2 - antagonistas de piridinona de integrinas alfa-4 - Google Patents
antagonistas de piridinona de integrinas alfa-4Info
- Publication number
- BRPI1015259A2 BRPI1015259A2 BRPI1015259A BRPI1015259A BRPI1015259A2 BR PI1015259 A2 BRPI1015259 A2 BR PI1015259A2 BR PI1015259 A BRPI1015259 A BR PI1015259A BR PI1015259 A BRPI1015259 A BR PI1015259A BR PI1015259 A2 BRPI1015259 A2 BR PI1015259A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyridinone
- integrin
- antagonists
- alpha
- pyridinone antagonists
- Prior art date
Links
- 108010041012 Integrin alpha4 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17287609P | 2009-04-27 | 2009-04-27 | |
| PCT/US2010/032632 WO2010126914A1 (en) | 2009-04-27 | 2010-04-27 | Pyridinone antagonists of alpha-4 integrins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1015259A2 true BRPI1015259A2 (pt) | 2016-05-03 |
Family
ID=42235905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1015259A BRPI1015259A2 (pt) | 2009-04-27 | 2010-04-27 | antagonistas de piridinona de integrinas alfa-4 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8367836B2 (pt) |
| EP (1) | EP2424841A1 (pt) |
| JP (1) | JP2012525336A (pt) |
| CN (1) | CN102459179A (pt) |
| AU (1) | AU2010241742A1 (pt) |
| BR (1) | BRPI1015259A2 (pt) |
| CA (1) | CA2760151A1 (pt) |
| IL (1) | IL215956A0 (pt) |
| MX (1) | MX2011011326A (pt) |
| SG (2) | SG10201401836RA (pt) |
| WO (1) | WO2010126914A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| CA2806341C (en) * | 2010-07-29 | 2020-03-24 | Rigel Pharmaceuticals, Inc. | Ampk-activating heterocyclic compounds and methods for using the same |
| KR101317656B1 (ko) * | 2011-06-30 | 2013-10-15 | 연세대학교 산학협력단 | 복제효소 인산화를 조절하는 신규 ｃ형 간염 예방 또는 치료용 조성물 |
| EP2562174A1 (de) * | 2011-08-24 | 2013-02-27 | Bayer Cropscience AG | Herbizid wirksame 6-Oxo-1,6-dihydropyrimidin-5-carboxamide und 2-Oxo-1,2-dihydropyridin-3-carboxamide |
| DK2810937T3 (en) * | 2012-01-31 | 2017-03-13 | Daiichi Sankyo Co Ltd | PYRIDONE DERIVATIVES |
| JP6326043B2 (ja) * | 2012-05-09 | 2018-05-16 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ５−ハロゲノピラゾールインダニルカルボキサミド類 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| TWI690525B (zh) * | 2014-07-07 | 2020-04-11 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| US9840513B2 (en) * | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
| WO2019200114A1 (en) * | 2018-04-12 | 2019-10-17 | Arbutus Biopharma Corporation | Methods for preparing substituted dihydroindene-4-carboxamide compounds |
| PT3873884T (pt) | 2018-10-30 | 2025-02-25 | Gilead Sciences Inc | Derivados de 3-(quinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidina-2,4-diona como inibidores da integrina alfa4beta7 para o tratamento de doenças inflamatórias |
| US11224600B2 (en) | 2018-10-30 | 2022-01-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| ES3003232T3 (en) | 2018-10-30 | 2025-03-10 | Gilead Sciences Inc | Compounds for inhibition of alpha4beta7 integrin |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| CA3131930A1 (en) * | 2019-02-28 | 2020-09-03 | Kezar Life Sciences | Thiazole derivatives as protein secretion inhibitors |
| US20220289679A1 (en) * | 2019-07-29 | 2022-09-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR102908219B1 (ko) | 2019-08-14 | 2026-01-08 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
| US20240150325A1 (en) * | 2021-02-02 | 2024-05-09 | Lg Chem, Ltd. | Novel compound as protein kinase inhibitors |
| WO2024240245A1 (en) * | 2023-05-25 | 2024-11-28 | Beijing Double-Crane Runchuang Technology Co., Ltd. | Fascin inhibitors |
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-
2010
- 2010-04-27 BR BRPI1015259A patent/BRPI1015259A2/pt not_active IP Right Cessation
- 2010-04-27 EP EP10719684A patent/EP2424841A1/en not_active Withdrawn
- 2010-04-27 JP JP2012507475A patent/JP2012525336A/ja active Pending
- 2010-04-27 CN CN2010800273757A patent/CN102459179A/zh active Pending
- 2010-04-27 AU AU2010241742A patent/AU2010241742A1/en not_active Abandoned
- 2010-04-27 CA CA2760151A patent/CA2760151A1/en not_active Abandoned
- 2010-04-27 SG SG10201401836RA patent/SG10201401836RA/en unknown
- 2010-04-27 MX MX2011011326A patent/MX2011011326A/es active IP Right Grant
- 2010-04-27 WO PCT/US2010/032632 patent/WO2010126914A1/en not_active Ceased
- 2010-04-27 US US12/768,680 patent/US8367836B2/en not_active Expired - Fee Related
- 2010-04-27 SG SG2011078409A patent/SG175355A1/en unknown
-
2011
- 2011-10-26 IL IL215956A patent/IL215956A0/en unknown
-
2012
- 2012-12-28 US US13/730,522 patent/US20130252957A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2424841A1 (en) | 2012-03-07 |
| MX2011011326A (es) | 2012-02-13 |
| JP2012525336A (ja) | 2012-10-22 |
| IL215956A0 (en) | 2012-01-31 |
| SG10201401836RA (en) | 2014-10-30 |
| CN102459179A (zh) | 2012-05-16 |
| SG175355A1 (en) | 2011-12-29 |
| US8367836B2 (en) | 2013-02-05 |
| CA2760151A1 (en) | 2010-11-04 |
| US20130252957A1 (en) | 2013-09-26 |
| WO2010126914A1 (en) | 2010-11-04 |
| AU2010241742A1 (en) | 2011-11-17 |
| US20110009407A1 (en) | 2011-01-13 |
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