HUP0002517A2 - Acil-piperazinilpirimidin-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és gyógyszerként való alkalmazásuk - Google Patents

Acil-piperazinilpirimidin-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és gyógyszerként való alkalmazásuk

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Publication number
HUP0002517A2
HUP0002517A2 HU0002517A HUP0002517A HUP0002517A2 HU P0002517 A2 HUP0002517 A2 HU P0002517A2 HU 0002517 A HU0002517 A HU 0002517A HU P0002517 A HUP0002517 A HU P0002517A HU P0002517 A2 HUP0002517 A2 HU P0002517A2
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Hungary
Prior art keywords
group
substituted
optionally
trifluoromethyl
acetamido
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HU0002517A
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English (en)
Inventor
Jordi Corbera Arjona
Jordi Frigola Constansa
David Vano Domenech
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Laboratorios Del Dr. Esteve, S.A.
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Application filed by Laboratorios Del Dr. Esteve, S.A. filed Critical Laboratorios Del Dr. Esteve, S.A.
Publication of HUP0002517A2 publication Critical patent/HUP0002517A2/hu
Publication of HUP0002517A3 publication Critical patent/HUP0002517A3/hu

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány tárgya (I) általános képletű acil-piperazinil-pirimidin-származékok és fiziológiailag elfogadható sói - a képletben Xjelentése oxigén- vagy kénatom; R1 jelentése 1-4 szénatomos alkoxi-vagy trifluormetil-csoport; R2 jelentése 1-6 szénatomos alkil-; 3-6szénatomos telített cikloalkil-; 3-6 gyűrű atomot tartalmazóheterociklusos csoport, ahol a heteroatom oxigén-, kén- vagynitrogénatom, és amely gyűrű adott esetben N-szubsztituált 1-6szénatomos alkilcsoporttal; fenil-, adott esetben 1-, 2-, 3-szorosanazonosan vagy különbözően fluor-, klór-, brómatommal, amino-,acetamido-, nitro-, metil-, trifluormetil- vagy metoxicsoporttalszubsztituálva van; arilalkil-csoport, amelyben az alkilcsoporton 1-3szénatomos és amely fenilcsoporttal szubsztituálva van, amelyfenilcsoport adott esetben 1-, 2-, 3-szorosan azonosan vagykülönbözően valamely következő csoporttal szubsztituálva van: fluor-,klór-, brómatom, amino-, acetamido-, nitro-, metil-, trifluormetil-vagy metoxicsoport; 5-6 gyűrű tagú heteroaril-csoport, amely adottesetben szubsztituált, vagy egy 9- vagy 10-tagú, kondenzált tartalmazóheteroaromás rendszer, amely adott esetben szubsztituálva lehet, ésamelyek egy vagy két heteroatomot tartalmaznak, ez lehet oxigén-, kén-vagy nitrogénatom és a szubsztituens lehet fluor-, klór- vagybrómatom, amino-, acetamido-, nitro-, metil-, triflurometil- vagymetoxicsoport; heteroarilalkil-csoport, amely tartalmaz egy 1-3szénatomos alkilcsoportot egy 5-vagy 6-tagú adott esetbenszubsztituált heteroaromás gyűrűből álló csoporttal vagy egy 9- vagy10-tagú kondenzált heteroaromás rendszerrel szubsztituálva, amelyekadott esetben 1-2 heteroatomot, így oxigén-, kén- vagy nitrogénatomottartalmaznak, és az adott esetben jelenlévő szubsztituens lehetfluor-, klór- vagy brómatom, amino-, acetamido-, nitro-, metil-,triflurometil- vagy metoxicsoport. A találmány szerinti vegyületek aközponti idegrendszerre hatnak. Ó
HU0002517A 1997-07-21 1998-07-21 Derivatives of acyl-piperazinil-pyrimidins, preparation thereof, pharmaceutical compositions containing them and their use as medicaments HUP0002517A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701627A ES2125206B1 (es) 1997-07-21 1997-07-21 Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
PCT/ES1998/000212 WO1999005121A1 (es) 1997-07-21 1998-07-21 Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos

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HUP0002517A2 true HUP0002517A2 (hu) 2001-06-28
HUP0002517A3 HUP0002517A3 (en) 2002-06-28

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HU0002517A HUP0002517A3 (en) 1997-07-21 1998-07-21 Derivatives of acyl-piperazinil-pyrimidins, preparation thereof, pharmaceutical compositions containing them and their use as medicaments

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US (1) US6372746B1 (hu)
EP (1) EP1006110B8 (hu)
JP (1) JP2001510831A (hu)
KR (1) KR100514148B1 (hu)
CN (1) CN1202087C (hu)
AR (1) AR017254A1 (hu)
AT (1) ATE259357T1 (hu)
AU (1) AU744633B2 (hu)
BG (1) BG64849B1 (hu)
BR (1) BR9810772A (hu)
CA (1) CA2297417C (hu)
CO (1) CO5011090A1 (hu)
DE (1) DE69821623T2 (hu)
DK (1) DK1006110T3 (hu)
EE (1) EE04151B1 (hu)
ES (2) ES2125206B1 (hu)
GE (1) GEP20033090B (hu)
HK (1) HK1032958A1 (hu)
HU (1) HUP0002517A3 (hu)
IN (1) IN183820B (hu)
IS (1) IS2076B (hu)
LT (1) LT4728B (hu)
LV (1) LV12457B (hu)
NO (1) NO314996B1 (hu)
NZ (1) NZ502400A (hu)
PL (1) PL195632B1 (hu)
PT (1) PT1006110E (hu)
RU (1) RU2205827C2 (hu)
SI (1) SI20269B (hu)
SK (1) SK284675B6 (hu)
TW (1) TW530056B (hu)
UA (1) UA59403C2 (hu)
WO (1) WO1999005121A1 (hu)
ZA (1) ZA986437B (hu)

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ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
MXPA03008143A (es) 2001-03-09 2005-08-16 Johnson & Johnson Compuestos heterociclicos.
US7390813B1 (en) * 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
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