HUP0402150A2 - A CB1 jelzésű kannabinoid receptorra nézve agonista, parciális agonista vagy antagonista hatású 1H-imidazol-származékok, eljárás az előállításukra, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents
A CB1 jelzésű kannabinoid receptorra nézve agonista, parciális agonista vagy antagonista hatású 1H-imidazol-származékok, eljárás az előállításukra, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállításáraInfo
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- HUP0402150A2 HUP0402150A2 HU0402150A HUP0402150A HUP0402150A2 HU P0402150 A2 HUP0402150 A2 HU P0402150A2 HU 0402150 A HU0402150 A HU 0402150A HU P0402150 A HUP0402150 A HU P0402150A HU P0402150 A2 HUP0402150 A2 HU P0402150A2
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- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000001270 agonistic effect Effects 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- RAXXELZNTBOGNW-MQIHXRCWSA-N 1h-imidazole Chemical class C1=C[15NH]C=[15N]1 RAXXELZNTBOGNW-MQIHXRCWSA-N 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 4
- 125000004434 sulfur atom Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- -1 fluoroacetyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004306 triazinyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 238000000889 atomisation Methods 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 229930003827 cannabinoid Natural products 0.000 abstract 1
- 239000003557 cannabinoid Substances 0.000 abstract 1
- 229940065144 cannabinoids Drugs 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 230000018405 transmission of nerve impulse Effects 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/30—Nitrogen atoms non-acylated
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
A találmány tárgyát képezik (I) általános képletű vegyületek, ezekprodrugjai, sztereoizomerjei és sói, az ezeket tartalmazógyógyszerkészítmények, eljárás az (I) és (II) általános képletűvegyületek, valamint az (I) általános képletű vegyületeket tartalmazógyógyszerkészítmények előállítására, eljárás az (I) általános képletűvegyületek alkalmazására a kannabinoidok közreműködésével lejátszódóidegi ingerületátvitellel kapcsolatos rendellenességek kezeléséreszolgáló gyógyszerkészítmények előállításánál, továbbá a találmánytárgyát képezik a (IX) és (X) általános képletű vegyületek is; ahol az(I) és (II) általános képletben R jelentése adott esetbenhelyettesített fenilcsoport, tienilcsoport, piridilcsoport,pirimidinilcsoport, pirazinilcsoport, piridazinilcsoport,triazinilcsoport vagy naftilcsoport, R1 jelentése adott esetbenhelyettesített fenilcsoport, piridilcsoport, pirimidinilcsoport,pirazinilcsoport, piridazinilcsoport, triazinilcsoport, naftilcsoport,vagy adott esetben helyettesített, öttagú, 1 vagy 2 nitrogénatomot,oxigénatomot és/vagy kénatomot tartalmazó aromás heterociklusoscsoport, R2 jelentése hidrogénatom, adott esetben egy kénatomot,oxigénatomot vagy nitrogénatomot tartalmazó alkilcsoport,cikloalkilcsoport, alkenilcsoport vagy cikloalkenilcsoport, R3jelentése adott esetben egy vagy több oxigénatomot, nitrogénatomotés/vagy kénatomot tartalmazó és adott esetben helyettesítettalkilcsoport, alkoxicsoport, cikloalkoxicsoport, cikloalkilcsoport,bicikloalkilcsoport, tricikloalkilcsoport, alkenilcsoport vagycikloalkenilcsoport, vagy adott esetben helyettesített benzilcsoport,fenil-etil-csoport, fenilcsoport vagy piridilcsoport, vagy NR5R6általános képletű csoport, vagy R2 és R3 együtt, továbbá azzal anitrogénatommal együtt, amelyhez kapcsolódnak, egy telített vagytelítetlen, a gyűrűben 4-10 atomot tartalmazó, adott esetbenhelyettesített és adott esetben egy vagy két nitrogénatomot,oxigénatomot és/vagy kénatomot tartalmazó heterociklusos csoportotképez, és R4 jelentése hidrogénatom, halogénatom, cianocsoport,karbamoilcsoport, formilcsoport, acetilcsoport, trifluor-acetil-csoport, fluor-acetil-csoport, propionilcsoport, szulfamoilcsoport,metánszulfonilcsoport, metil-szulfanil-csoport vagy adott esetbenhelyettesített alkilcsoport; R7 alkil vagy benzilcsoport ; R, R1 és R4jelentése az 1. igénypontban megadott, és R9 jelentésehidroxilcsoport, egyenes vagy elágazó szénláncú 1-4 szénatomosalkoxicsoport, benziloxicsoport vagy klóratom; és a (X) általánosképletben R jelentése 4-klór-fenil-csoport, 4-bróm-fenil-csoport vagy4-(trifluor--metil)-fenil-csoport. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01203851 | 2001-09-21 | ||
PCT/EP2002/010434 WO2003027076A2 (en) | 2001-09-21 | 2002-09-17 | 1h-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1- antagonistic activity |
Publications (2)
Publication Number | Publication Date |
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HUP0402150A2 true HUP0402150A2 (hu) | 2005-02-28 |
HUP0402150A3 HUP0402150A3 (en) | 2005-08-29 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HU0402150A HUP0402150A3 (en) | 2001-09-21 | 2002-09-17 | 1h-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1-antagonistic activity, process for the preparation, pharmaceutical compositions containing them and their use for production of pharmaceutical compositions |
Country Status (26)
Country | Link |
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US (2) | US20040235854A1 (hu) |
EP (1) | EP1438296B1 (hu) |
JP (1) | JP4393869B2 (hu) |
KR (1) | KR100950431B1 (hu) |
CN (2) | CN101538244A (hu) |
AR (1) | AR036597A1 (hu) |
AT (1) | ATE415391T1 (hu) |
AU (1) | AU2002337106B2 (hu) |
BR (1) | BR0212481A (hu) |
CA (1) | CA2457444C (hu) |
DE (1) | DE60230054D1 (hu) |
DK (1) | DK1438296T3 (hu) |
ES (1) | ES2318045T3 (hu) |
HR (1) | HRP20040185A2 (hu) |
HU (1) | HUP0402150A3 (hu) |
IL (2) | IL160522A0 (hu) |
MX (1) | MXPA04002669A (hu) |
NO (1) | NO20041171L (hu) |
PL (1) | PL367998A1 (hu) |
PT (1) | PT1438296E (hu) |
RU (1) | RU2299200C2 (hu) |
SI (1) | SI1438296T1 (hu) |
TW (1) | TWI231757B (hu) |
UA (1) | UA77440C2 (hu) |
WO (1) | WO2003027076A2 (hu) |
ZA (1) | ZA200402188B (hu) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
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