PE20071320A1 - Moduladores de receptores cannabinoides - Google Patents

Moduladores de receptores cannabinoides

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Publication number
PE20071320A1
PE20071320A1 PE2007000047A PE2007000047A PE20071320A1 PE 20071320 A1 PE20071320 A1 PE 20071320A1 PE 2007000047 A PE2007000047 A PE 2007000047A PE 2007000047 A PE2007000047 A PE 2007000047A PE 20071320 A1 PE20071320 A1 PE 20071320A1
Authority
PE
Peru
Prior art keywords
substituted
alkyl
halogen
tetrahydroisoindolin
ona
Prior art date
Application number
PE2007000047A
Other languages
English (en)
Inventor
Samuel Chackalamannil
Mariappan V Chelliah
Martin C Clasby
Keith A Eagen
Jack D Scott
Yuguang Wang
Yan Xia
William J Greenlee
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20071320A1 publication Critical patent/PE20071320A1/es

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE m ES 0-1; n ES 1-2; LAS LINEAS DISCONTINUAS SON ENLACES SIMPLES O DOBLES; R1 ES C(O)-N(R10)2, C(O)-O-ALQUILO, C(O)-R14; R2 ES H, ALQUILO SUSTITUIDO O NO CON UNO O MAS GRUPOS OH, O-ALQUILO, -OARILO, -ALQUILEN-N(R10)2, ENTRE OTROS; R10 ES H, ALQUILO SUSTITUIDO O NO, R14, HETEROCICLOALQUILO, ENTRE OTROS; R14 ES CICLOALQUILO SUSTITUIDO O NO, ENTRE OTROS; R15 ES H, N3, HALOGENO, ALQUENILO, ENTRE OTROS; Ar1 y Ar2 SON CADA UNO R12, R13, DONDE R12 ES ARILO SUSTITUIDO O NO CON X1; R13 ES HETEROARILO SUSTITUIDO O NO CON X2; X1 ES HALOGENO, CN, OH, ENTRE OTROS; X2 ES HALOGENO, CN, OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(4-CLOROFENIL)-5-[(4-METOXI-2-CLORO)FENIL]-8-ETIL-4,5,6,7-TETRAHIDROISOINDOLIN-1-ONA, 3-METANOL-4-(4-CLOROFENIL)-5-[2-CLORO-4-(1-METIL-PIRAZOL-3-IL)FENIL]-8-ETIL-4,5,6,7-TETRAHIDROISOINDOLIN-1-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS MODULAN LA ACTIVIDAD DE LOS RECEPTORES CANNABINOIDE, UTILES EN TRATAMIENTO DE LA OBESIDAD, TRASTORNOS DEL METABOLISMO, ADICCION, ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL, TRASTORNOS CARDIOVASCULAR, ENTRE OTROS
PE2007000047A 2006-01-18 2007-01-16 Moduladores de receptores cannabinoides PE20071320A1 (es)

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US20070197628A1 (en) 2007-08-23
MX2008009354A (es) 2008-09-30
US7897601B2 (en) 2011-03-01
AR059021A1 (es) 2008-03-05
KR20080097426A (ko) 2008-11-05
NZ569814A (en) 2011-10-28
EP1973877A2 (en) 2008-10-01
WO2007084450A3 (en) 2007-11-08
RU2008133381A (ru) 2010-02-27
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WO2007084450A2 (en) 2007-07-26
BRPI0706623A2 (pt) 2011-04-12

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