CL2008001634A1 - Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo. - Google Patents

Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo.

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Publication number
CL2008001634A1
CL2008001634A1 CL2008001634A CL2008001634A CL2008001634A1 CL 2008001634 A1 CL2008001634 A1 CL 2008001634A1 CL 2008001634 A CL2008001634 A CL 2008001634A CL 2008001634 A CL2008001634 A CL 2008001634A CL 2008001634 A1 CL2008001634 A1 CL 2008001634A1
Authority
CL
Chile
Prior art keywords
notch1
antibody
vector
hvr
polynucleotide
Prior art date
Application number
CL2008001634A
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English (en)
Inventor
Yan Wu
Christian W Siebel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001634(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2008001634A1 publication Critical patent/CL2008001634A1/es

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Abstract

UN ANTICUERPO DE LA REGIÓN REGULATORIA NEGATIVA (NRR) ANTI-NOTCHL AISLADO, SE UNE A UN NOTCH1 NRR CON UNA KD DE 1 X 10-7 O MAYOR, DONDE DICHO ANTICUERPO, CUANDO SE UNE A DICHO NOTCHL NRR, DISMINUYE LA SEÑALIZACIÓN DE NOTCH1, Y DONDE EL ANTICUERPO COMPRENDE HVR•L1, HVR•L2, HVR•L3, HVR•HL. HVR•H2 Y HVR•H3, DONDE CADA UNO, EN ORDEN, COMPRENDE: (I) SEA ID NO: 7, 8, 9, 1, 2, 6; (II)SEO ID NO: 7, 8, LA, 1, 3, 6; (III) SEA ID NO: 7, 8,11,1,4,6; O (IV) SEA ID NO: 7, 8, 12, 1, 5, 6. UN POLINUCLEÓTIDO QUE LO CODIFICA. UN VECTOR QUE COMPRENDE DICHO POLINUCLEÓTIDO. UNA CÉLULA HUÉSPED QUE COMPRENDE DICHO VECTOR. UN MÉTODO PARA PREPARAR UN ANTICUERPO ANTI-NOTCH1 NRR, DONDE DICHO MÉTODO COMPRENDE (A) EXPRESAR DICHO VECTOR EN UNA CÉLULA HUÉSPED ADECUADA Y (B) RECUPERAR EL ANTICUERPO. UNA COMPOSICIÓN QUE COMPRENDE UN ANTICUERPO ANTI-NOTCH1 NRR. USO DE UNA CANTIDAD EFECTIVA DE UN ANTICUERPO ANTI-NOTCH1 NRR, PARA PREPARAR UN MEDICAMENTO ÚTIL PARA TRATAR TRASTORNOS ASOCIADOS CON AUMENTO DE LA SEÑALIZACIÓN O EXPRESIÓN DE NOTCH1 O CON UNA MUTACIÓN EN UNA SECUENCIA DE AMINOÁCIDOS DE NOTCH1 EN UN INDIVIDUO, PARA TRATAR CÁNCER, UN TUMOR Y/O UN TRASTORNO PROLIFERATIVO CELULAR EN UN INDIVIDUO, ENTRE OTROS.
CL2008001634A 2007-06-04 2008-06-04 Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo. CL2008001634A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US99464607P 2007-09-20 2007-09-20

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CL2008001634A1 true CL2008001634A1 (es) 2009-05-22

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CL2008001634A CL2008001634A1 (es) 2007-06-04 2008-06-04 Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo.

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Families Citing this family (37)

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US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
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