BR112013015122A2 - anticorpos anti-notch1 - Google Patents

anticorpos anti-notch1

Info

Publication number
BR112013015122A2
BR112013015122A2 BR112013015122A BR112013015122A BR112013015122A2 BR 112013015122 A2 BR112013015122 A2 BR 112013015122A2 BR 112013015122 A BR112013015122 A BR 112013015122A BR 112013015122 A BR112013015122 A BR 112013015122A BR 112013015122 A2 BR112013015122 A2 BR 112013015122A2
Authority
BR
Brazil
Prior art keywords
notch1 antibodies
notch1
antibodies
Prior art date
Application number
BR112013015122A
Other languages
English (en)
Inventor
Stephen Zhou Bin-Bing
Bard Joel
G Geles Kenneth
Gennadievna Tchistiakova Lioudmila
Gao Yijie
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BR112013015122A2 publication Critical patent/BR112013015122A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
BR112013015122A 2010-12-15 2011-12-09 anticorpos anti-notch1 BR112013015122A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42357810P 2010-12-15 2010-12-15
US201161552578P 2011-10-28 2011-10-28
PCT/IB2011/055595 WO2012080926A2 (en) 2010-12-15 2011-12-09 Anti-notch1 antibodies

Publications (1)

Publication Number Publication Date
BR112013015122A2 true BR112013015122A2 (pt) 2017-05-30

Family

ID=45444674

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013015122A BR112013015122A2 (pt) 2010-12-15 2011-12-09 anticorpos anti-notch1

Country Status (20)

Country Link
US (2) US9127060B2 (pt)
EP (1) EP2651977A2 (pt)
JP (1) JP6016800B2 (pt)
KR (2) KR20150088334A (pt)
CN (2) CN103547594B (pt)
AR (1) AR084315A1 (pt)
AU (2) AU2011342799B2 (pt)
BR (1) BR112013015122A2 (pt)
CA (1) CA2821130C (pt)
CO (1) CO6791565A2 (pt)
HK (1) HK1194388A1 (pt)
MX (1) MX346995B (pt)
NZ (1) NZ611785A (pt)
PE (1) PE20141109A1 (pt)
PH (1) PH12017500864A1 (pt)
RU (1) RU2622083C2 (pt)
SA (1) SA111330060B1 (pt)
SG (1) SG191039A1 (pt)
TW (1) TWI471333B (pt)
WO (1) WO2012080926A2 (pt)

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WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
CN102686610A (zh) 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体
CN103547594B (zh) 2010-12-15 2016-05-11 惠氏有限责任公司 抗缺刻蛋白1抗体
CA2885659A1 (en) * 2012-09-21 2014-03-27 Oncomed Pharmaceuticals, Inc. Methods of treating hematological malignancies with notch1 antibodies
EP2917240A1 (en) 2012-11-07 2015-09-16 Pfizer Inc. Anti-notch3 antibodies and antibody-drug conjugates
KR20170029490A (ko) 2014-07-11 2017-03-15 제넨테크, 인크. 노치 경로 억제
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
SG11201802698XA (en) * 2015-10-29 2018-05-30 Hoffmann La Roche Transgenic rabbit with common light chain
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
US11590152B2 (en) 2018-01-26 2023-02-28 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
KR20210008840A (ko) * 2018-04-10 2021-01-25 스티흐팅 산퀸 불드포르지닝 키메라 노치 수용체
KR102499678B1 (ko) * 2020-02-27 2023-02-15 주식회사 베르티스 암의 진단용 조성물

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Also Published As

Publication number Publication date
CA2821130A1 (en) 2012-06-21
TWI471333B (zh) 2015-02-01
CA2821130C (en) 2017-11-07
PH12017500864A1 (en) 2017-12-11
KR101580726B1 (ko) 2015-12-29
JP2014503205A (ja) 2014-02-13
KR20150088334A (ko) 2015-07-31
RU2622083C2 (ru) 2017-06-09
SG191039A1 (en) 2013-08-30
EP2651977A2 (en) 2013-10-23
MX2013006875A (es) 2013-07-05
AU2011342799A1 (en) 2013-07-04
NZ611785A (en) 2015-04-24
RU2013126494A (ru) 2015-01-20
PE20141109A1 (es) 2014-09-24
AR084315A1 (es) 2013-05-08
AU2016219704A1 (en) 2016-09-15
KR20130108430A (ko) 2013-10-02
HK1194388A1 (zh) 2014-10-17
CO6791565A2 (es) 2013-11-14
AU2011342799B2 (en) 2016-06-09
CN103547594A (zh) 2014-01-29
WO2012080926A2 (en) 2012-06-21
US9127060B2 (en) 2015-09-08
US20130266594A1 (en) 2013-10-10
JP6016800B2 (ja) 2016-10-26
US20160002331A1 (en) 2016-01-07
CN103547594B (zh) 2016-05-11
MX346995B (es) 2017-04-06
SA111330060B1 (ar) 2015-06-04
CN105884896A (zh) 2016-08-24
TW201302787A (zh) 2013-01-16
WO2012080926A3 (en) 2012-10-04

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2544 DE 08-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.