MA33973B1 - Méthodes de traitement du cancer à l'aide d'antagonistes de notch - Google Patents
Méthodes de traitement du cancer à l'aide d'antagonistes de notchInfo
- Publication number
- MA33973B1 MA33973B1 MA34797A MA34797A MA33973B1 MA 33973 B1 MA33973 B1 MA 33973B1 MA 34797 A MA34797 A MA 34797A MA 34797 A MA34797 A MA 34797A MA 33973 B1 MA33973 B1 MA 33973B1
- Authority
- MA
- Morocco
- Prior art keywords
- ways
- treat cancer
- notch
- notch antagonists
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
La présente invention porte sur des méthodes pour le traitement du cancer en général, et de la leucémie en particulier, à l'aide d'antagonistes de Notch1 et de Notch3 séparément ou en combinaison. L'invention porte également sur des compositions et sur des méthodes pour le traitement et le diagnostic de cancers associés à Notch.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24729809P | 2009-09-30 | 2009-09-30 | |
PCT/US2010/050610 WO2011041336A2 (fr) | 2009-09-30 | 2010-09-29 | Méthodes de traitement du cancer à l'aide d'antagonistes de notch |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33973B1 true MA33973B1 (fr) | 2013-02-01 |
Family
ID=43127684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34797A MA33973B1 (fr) | 2009-09-30 | 2010-09-29 | Méthodes de traitement du cancer à l'aide d'antagonistes de notch |
Country Status (21)
Country | Link |
---|---|
US (1) | US9200071B2 (fr) |
EP (1) | EP2483311B1 (fr) |
JP (3) | JP6025563B2 (fr) |
KR (1) | KR101782180B1 (fr) |
CN (1) | CN102630229B (fr) |
AU (1) | AU2010300747A1 (fr) |
BR (1) | BR112012007252A2 (fr) |
CA (1) | CA2775880A1 (fr) |
CL (1) | CL2012000800A1 (fr) |
CO (1) | CO6531430A2 (fr) |
CR (1) | CR20120213A (fr) |
EC (1) | ECSP12011858A (fr) |
ES (1) | ES2580229T3 (fr) |
HK (1) | HK1170505A1 (fr) |
IL (1) | IL218662A0 (fr) |
MA (1) | MA33973B1 (fr) |
MX (1) | MX342250B (fr) |
PE (1) | PE20120998A1 (fr) |
RU (1) | RU2012117619A (fr) |
WO (1) | WO2011041336A2 (fr) |
ZA (1) | ZA201201984B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7919092B2 (en) | 2006-06-13 | 2011-04-05 | Oncomed Pharmaceuticals, Inc. | Antibodies to notch receptors |
EP2125887A4 (fr) | 2007-01-24 | 2010-11-10 | Oncomed Pharm Inc | Compositions et procedes utilises pour le diagnostic et le traitement du cancer |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
PL2307459T3 (pl) | 2008-07-08 | 2015-05-29 | Oncomed Pharm Inc | Czynniki wiążące receptor Notch1 i sposoby ich stosowania |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
RU2011151287A (ru) | 2009-06-18 | 2013-07-27 | Пфайзер Инк. | АНТИ Notch-1 АНТИТЕЛА |
RU2622083C2 (ru) | 2010-12-15 | 2017-06-09 | ВАЙЕТ ЭлЭлСи | Антитела против notch1 |
AU2013343045A1 (en) * | 2012-11-07 | 2015-05-21 | Pfizer Inc. | Anti-Notch3 antibodies and antibody-drug conjugates |
ES2737649T3 (es) | 2012-12-19 | 2020-01-15 | Aveo Pharmaceuticals Inc | Anticuerpos anti-Notch3 |
WO2014159239A2 (fr) * | 2013-03-14 | 2014-10-02 | Novartis Ag | Anticorps dirigés contre notch 3 |
WO2014159242A1 (fr) * | 2013-03-14 | 2014-10-02 | Novartis Ag | Mutants de notch 3 et leurs utilisations |
WO2014151606A2 (fr) * | 2013-03-15 | 2014-09-25 | Oncomed Pharmaceuticals, Inc. | Procédés de traitement du cancer du pancréas |
KR20160104612A (ko) | 2013-07-26 | 2016-09-05 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조성물 |
JP6571115B2 (ja) | 2014-02-12 | 2019-09-04 | ジェネンテック, インコーポレイテッド | 抗jagged1抗体及び使用方法 |
KR20170029490A (ko) | 2014-07-11 | 2017-03-15 | 제넨테크, 인크. | 노치 경로 억제 |
CN105585636B (zh) * | 2015-11-24 | 2020-03-03 | 南方医科大学 | 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用 |
WO2017190025A1 (fr) * | 2016-04-29 | 2017-11-02 | Aveo Pharmaceuticals, Inc. | Anticorps anti-notch3 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
CA2219361C (fr) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Anticorps humains derives d'une xenosouris immunisee |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
EP2305027B1 (fr) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Mammifères trangèniques obtenus par génie génétique contenant des loci des immunoglobulines humaines qui comprennent plusieurs régions de VH et de Vkappa, et anticorps aussi obtenus. |
EP1034298B1 (fr) | 1997-12-05 | 2011-11-02 | The Scripps Research Institute | Humanisation d'anticorps murins |
EA200701211A1 (ru) | 2004-12-31 | 2007-12-28 | Дженентек, Инк. | Полипептиды, которые связываются с br3, и их применение |
PE20081264A1 (es) | 2006-10-19 | 2008-10-01 | Genentech Inc | Anticuerpos agonistas anti-notch3 |
CA2666179A1 (fr) | 2006-10-19 | 2008-11-13 | Genentech, Inc. | Nouveaux anticorps anti-notch3 et leur utilisation dans la detection et le diagnostic d'une maladie |
US7935791B2 (en) * | 2006-12-18 | 2011-05-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
EP2125887A4 (fr) * | 2007-01-24 | 2010-11-10 | Oncomed Pharm Inc | Compositions et procedes utilises pour le diagnostic et le traitement du cancer |
US20100062012A1 (en) * | 2007-03-05 | 2010-03-11 | Ioannides Constantin G | Negative Genetic Regulation of Cancer Cell Renewal in Synergy with Notch- or Numb-Specific Immunotherapy |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
PL2307459T3 (pl) * | 2008-07-08 | 2015-05-29 | Oncomed Pharm Inc | Czynniki wiążące receptor Notch1 i sposoby ich stosowania |
WO2010141249A2 (fr) * | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Génération, caractérisation et utilisations d'anticorps anti-notch3 |
RU2011151287A (ru) * | 2009-06-18 | 2013-07-27 | Пфайзер Инк. | АНТИ Notch-1 АНТИТЕЛА |
-
2010
- 2010-09-29 ES ES10762827.3T patent/ES2580229T3/es active Active
- 2010-09-29 EP EP10762827.3A patent/EP2483311B1/fr active Active
- 2010-09-29 WO PCT/US2010/050610 patent/WO2011041336A2/fr active Application Filing
- 2010-09-29 BR BR112012007252-8A patent/BR112012007252A2/pt not_active IP Right Cessation
- 2010-09-29 CA CA2775880A patent/CA2775880A1/fr not_active Abandoned
- 2010-09-29 RU RU2012117619/10A patent/RU2012117619A/ru not_active Application Discontinuation
- 2010-09-29 PE PE2012000413A patent/PE20120998A1/es not_active Application Discontinuation
- 2010-09-29 MA MA34797A patent/MA33973B1/fr unknown
- 2010-09-29 CN CN201080054108.9A patent/CN102630229B/zh active Active
- 2010-09-29 JP JP2012532248A patent/JP6025563B2/ja active Active
- 2010-09-29 US US13/498,560 patent/US9200071B2/en active Active
- 2010-09-29 AU AU2010300747A patent/AU2010300747A1/en not_active Abandoned
- 2010-09-29 KR KR1020127010886A patent/KR101782180B1/ko active IP Right Grant
- 2010-09-29 MX MX2012003851A patent/MX342250B/es active IP Right Grant
-
2012
- 2012-03-15 IL IL218662A patent/IL218662A0/en unknown
- 2012-03-16 ZA ZA2012/01984A patent/ZA201201984B/en unknown
- 2012-03-30 CL CL2012000800A patent/CL2012000800A1/es unknown
- 2012-04-09 CO CO12057624A patent/CO6531430A2/es not_active Application Discontinuation
- 2012-04-26 CR CR20120213A patent/CR20120213A/es unknown
- 2012-04-30 EC ECSP12011858 patent/ECSP12011858A/es unknown
- 2012-11-08 HK HK12111268.8A patent/HK1170505A1/xx unknown
-
2015
- 2015-01-23 JP JP2015011573A patent/JP2015145362A/ja not_active Withdrawn
-
2016
- 2016-07-13 JP JP2016138236A patent/JP2017014219A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20120328608A1 (en) | 2012-12-27 |
US9200071B2 (en) | 2015-12-01 |
BR112012007252A2 (pt) | 2020-08-11 |
IL218662A0 (en) | 2012-05-31 |
JP2017014219A (ja) | 2017-01-19 |
JP6025563B2 (ja) | 2016-11-16 |
EP2483311A2 (fr) | 2012-08-08 |
HK1170505A1 (en) | 2013-03-01 |
JP2015145362A (ja) | 2015-08-13 |
MX342250B (es) | 2016-09-22 |
CN102630229A (zh) | 2012-08-08 |
KR101782180B1 (ko) | 2017-10-23 |
AU2010300747A1 (en) | 2012-04-26 |
CN102630229B (zh) | 2015-03-04 |
ZA201201984B (en) | 2013-05-29 |
JP2013506675A (ja) | 2013-02-28 |
PE20120998A1 (es) | 2012-08-14 |
KR20120100952A (ko) | 2012-09-12 |
CR20120213A (es) | 2012-07-09 |
WO2011041336A3 (fr) | 2012-05-03 |
EP2483311B1 (fr) | 2016-05-18 |
ES2580229T3 (es) | 2016-08-22 |
RU2012117619A (ru) | 2013-11-10 |
CL2012000800A1 (es) | 2012-08-31 |
MX2012003851A (es) | 2012-05-08 |
CA2775880A1 (fr) | 2011-04-07 |
WO2011041336A2 (fr) | 2011-04-07 |
CO6531430A2 (es) | 2012-09-28 |
ECSP12011858A (es) | 2012-06-29 |
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