MX2012003851A - Tratamiento de cánceres resistentes antagonistas notch1, mediante el uso de antagonistas notch3. - Google Patents

Tratamiento de cánceres resistentes antagonistas notch1, mediante el uso de antagonistas notch3.

Info

Publication number
MX2012003851A
MX2012003851A MX2012003851A MX2012003851A MX2012003851A MX 2012003851 A MX2012003851 A MX 2012003851A MX 2012003851 A MX2012003851 A MX 2012003851A MX 2012003851 A MX2012003851 A MX 2012003851A MX 2012003851 A MX2012003851 A MX 2012003851A
Authority
MX
Mexico
Prior art keywords
methods
treating cancer
notch
notch antagonists
antagonists
Prior art date
Application number
MX2012003851A
Other languages
English (en)
Other versions
MX342250B (es
Inventor
Christian W Siebel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2012003851A publication Critical patent/MX2012003851A/es
Publication of MX342250B publication Critical patent/MX342250B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

La presente invención se refiere a métodos para el tratamiento del cáncer en general y leucemia en particular, utilizando antagonistas de Notch1 y Notch3 solos o en combinación. También se proporcionan composiciones y métodos para el tratamiento y diagnóstico de tipos de cáncer asociados a Notch.
MX2012003851A 2009-09-30 2010-09-29 Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3. MX342250B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24729809P 2009-09-30 2009-09-30
PCT/US2010/050610 WO2011041336A2 (en) 2009-09-30 2010-09-29 Methods of treating cancer using notch antagonists

Publications (2)

Publication Number Publication Date
MX2012003851A true MX2012003851A (es) 2012-05-08
MX342250B MX342250B (es) 2016-09-22

Family

ID=43127684

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012003851A MX342250B (es) 2009-09-30 2010-09-29 Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3.

Country Status (21)

Country Link
US (1) US9200071B2 (es)
EP (1) EP2483311B1 (es)
JP (3) JP6025563B2 (es)
KR (1) KR101782180B1 (es)
CN (1) CN102630229B (es)
AU (1) AU2010300747A1 (es)
BR (1) BR112012007252A2 (es)
CA (1) CA2775880A1 (es)
CL (1) CL2012000800A1 (es)
CO (1) CO6531430A2 (es)
CR (1) CR20120213A (es)
EC (1) ECSP12011858A (es)
ES (1) ES2580229T3 (es)
HK (1) HK1170505A1 (es)
IL (1) IL218662A0 (es)
MA (1) MA33973B1 (es)
MX (1) MX342250B (es)
PE (1) PE20120998A1 (es)
RU (1) RU2012117619A (es)
WO (1) WO2011041336A2 (es)
ZA (1) ZA201201984B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539403A (ja) 2006-06-13 2009-11-19 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌を診断および処置するための組成物および方法
CA2676008A1 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090321A1 (es) * 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
CN102686610A (zh) 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体
MX346995B (es) 2010-12-15 2017-04-06 Wyeth Llc Anticuerpos anti-notch1.
TWI589590B (zh) * 2012-11-07 2017-07-01 輝瑞股份有限公司 抗切口３（ａｎｔｉ-ｎｏｔｃｈ３）抗體及抗體-藥物共軛體
PL2935330T3 (pl) * 2012-12-19 2019-11-29 Aveo Pharmaceuticals Inc Przeciwciała przeciw notch3
EP3611189A1 (en) * 2013-03-14 2020-02-19 Novartis AG Antibodies against notch 3
WO2014159242A1 (en) * 2013-03-14 2014-10-02 Novartis Ag Notch 3 mutants and uses thereof
EP2971146A4 (en) * 2013-03-15 2016-11-09 Oncomed Pharm Inc METHOD FOR THE TREATMENT OF PANCREATIC CANCER
EP3024457A4 (en) 2013-07-26 2017-06-28 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
AR099465A1 (es) * 2014-02-12 2016-07-27 Genentech Inc Anticuerpos anti-jagged1 y métodos de uso
CN106488775A (zh) 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
US11142573B2 (en) 2016-04-29 2021-10-12 Aveo Pharmaceuticals, Inc. Anti-Notch3 antibody

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
EP1709970A1 (en) 1995-04-27 2006-10-11 Abgenix, Inc. Human antibodies against EGFR, derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
BR9813365A (pt) 1997-12-05 2004-06-15 Scripps Research Inst Método para produção e humanização de um anticorpo monoclonal de rato
MX2007008017A (es) 2004-12-31 2007-09-12 Genentech Inc Polipeptidos que se ligan a br3 y usos de los mismos.
AU2007309229B8 (en) 2006-10-19 2013-05-09 Genentech, Inc. Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases
TW200823293A (en) 2006-10-19 2008-06-01 Genentech Inc Novel anti-Notch3 antibodies and their use in the detection and diagnosis of disease
TWI419904B (zh) 2006-12-18 2013-12-21 Genentech Inc 拮抗劑抗-ｎｏｔｃｈ３抗體及其用於預防及治療ｎｏｔｃｈ３相關疾病之用途
CA2676008A1 (en) * 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
WO2008108910A2 (en) * 2007-03-05 2008-09-12 Board Of Regents, The University Of Texas System Negative genetic regulation of cancer cell renewal in synergy with notch- or numb-specific immunotherapy
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
CN102112490B (zh) * 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
WO2010141249A2 (en) * 2009-06-02 2010-12-09 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-notch3 antibodies
CN102686610A (zh) * 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体

Also Published As

Publication number Publication date
JP2013506675A (ja) 2013-02-28
CR20120213A (es) 2012-07-09
RU2012117619A (ru) 2013-11-10
US20120328608A1 (en) 2012-12-27
ES2580229T3 (es) 2016-08-22
WO2011041336A2 (en) 2011-04-07
PE20120998A1 (es) 2012-08-14
JP2015145362A (ja) 2015-08-13
IL218662A0 (en) 2012-05-31
ECSP12011858A (es) 2012-06-29
MX342250B (es) 2016-09-22
KR101782180B1 (ko) 2017-10-23
HK1170505A1 (en) 2013-03-01
ZA201201984B (en) 2013-05-29
US9200071B2 (en) 2015-12-01
JP2017014219A (ja) 2017-01-19
CN102630229A (zh) 2012-08-08
CL2012000800A1 (es) 2012-08-31
EP2483311A2 (en) 2012-08-08
CN102630229B (zh) 2015-03-04
BR112012007252A2 (pt) 2020-08-11
CA2775880A1 (en) 2011-04-07
EP2483311B1 (en) 2016-05-18
JP6025563B2 (ja) 2016-11-16
CO6531430A2 (es) 2012-09-28
MA33973B1 (fr) 2013-02-01
AU2010300747A1 (en) 2012-04-26
KR20120100952A (ko) 2012-09-12
WO2011041336A3 (en) 2012-05-03

Similar Documents

Publication Publication Date Title
MX342250B (es) Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3.
EP2569434A4 (en) COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA
IN2012DN02081A (es)
MX360404B (es) Compuestos para inhibir la proliferacion celular en canceres transmitidos por egfr.
TR200906131T1 (tr) Aktivin -actrIIa antagonistleri ve göğüs kanserinin tedavi e
CR20120202A (es) Métodos y composiciones para tratar cáncer
EA201171367A1 (ru) Винилиндазолильные соединения
WO2011037643A3 (en) Compositions and methods for detecting and treating prostate carcinoma
MX2013006392A (es) Tratamiento de cancer positivo para her2 con paclitaxel y trastuzumab-mcc-dm1.
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
MX2011007930A (es) Conjugados de insulina cristalina.
MX2010000465A (es) Metodos y composiciones para el tratamiento de cancer, tumores y alteraciones relacionadas con tumores.
MX2009008347A (es) Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
MX2012010434A (es) Compuestos y composiciones novedosas para atacar a las celulas madre del cancer.
MX2009008510A (es) Antagonistas de activina-actriia y usos para promover el crecimiento de huesos en pacientes con cancer.
EA201270606A1 (ru) Новое противоопухолевое применение кабазитаксела
MX2015007185A (es) Uso de eribulina en el tratamiento de cancer de pecho.
WO2010101793A3 (en) Methods and compositions for the diagnosis, prognosis and treatment of cancer
MX2013002155A (es) Compuestos para el tratamiento de cancer.
FR2945210B1 (fr) Combinaison antitumorale comprenant l'ave8062 et le sorafenib
MX2010009697A (es) Tratamientos anticancerigenos mejorados.
MX2011006532A (es) Compuestos anticancerigenos.
WO2013070933A3 (en) Compositions and methods for the treatment of prostate carcinoma
WO2010002454A3 (en) Therapeutic combinations for use in neoplasia
TN2010000463A1 (en) Compositions and methods for preparing and using same

Legal Events

Date Code Title Description
FG Grant or registration