MX337468B - Anticuerpos anti notch-1. - Google Patents

Anticuerpos anti notch-1.

Info

Publication number
MX337468B
MX337468B MX2011013717A MX2011013717A MX337468B MX 337468 B MX337468 B MX 337468B MX 2011013717 A MX2011013717 A MX 2011013717A MX 2011013717 A MX2011013717 A MX 2011013717A MX 337468 B MX337468 B MX 337468B
Authority
MX
Mexico
Prior art keywords
epitope
antibodies
notch1
nrr
domain
Prior art date
Application number
MX2011013717A
Other languages
English (en)
Other versions
MX2011013717A (es
Inventor
Zdenek Hostomsky
Kang Li
John Andrew Lippincott
Qinghai Peng
Donna Marie Stone
Ping Wei
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX337468(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of MX2011013717A publication Critical patent/MX2011013717A/es
Publication of MX337468B publication Critical patent/MX337468B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención se refiere a un método para preparar una masa de pan fermentada, el método comprende la siguiente secuencia de pasos de procesamientos: a) combinar harina, agua, levadura y/o agente de fermentación y opcionalmente uno o más ingredientes de panadería adicionales para producir una mezcla de tipo masa; b) mezclar y trabajar la mezcla de tipo masa en una mezclador a para producir una masa subdesarrollada con una densidad de 0.9-1.5 g/ml, la entrada de energía total de la mezcladora en la masa subdesarrollada durante el mezclado y el trabajo de la mezcla de tipo masa es por lo menos 1 W.h/Kg; c) trabajar adicionalmente un lote de por lo menos 15 kg de masa subdesarrollada al someterla a esfuerzo cortante de deformación, produciendo de ese modo una masa desarrollada; d) dividir la masa desarrollada en dos o más piezas de masa desarrollada que tienen una masa individual de 30-3000 g; y e) fermentar las piezas de masa desarrollada para generar piezas de masa fermentada que tienen un volumen específico de por lo menos 2.0 ml/g; en donde la secuencia mencionada anteriormente de pasos de procesamiento se completa dentro de 3 horas. El presente proceso emplea trabajo de alta energía para producir una masa subdesarrollada, seguido de trabajo de baja energía para desarrollar adicionalmente la masa. Al emplear una combinación de trabajo de alta energía y trabajo de baja energía, la energía de trabajo total necesaria para la preparación de una masa completamente desarrollada se puede reducir sustancialmente. Al mismo tiempo, esta combinación de condiciones de trabajo produce una masa que después del horneado genera una migaja muy suave con una estructura de migaja extremadamente regular. La invención proporciona además una barra de pan de mole que tiene una estructura celular única que se puede obtener por medio del método mencionado anteriormente, así como también un aparato para operar el método mencionado anteriormente.
MX2011013717A 2009-06-18 2010-06-16 Anticuerpos anti notch-1. MX337468B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21819309P 2009-06-18 2009-06-18
PCT/IB2010/052711 WO2010146550A1 (en) 2009-06-18 2010-06-16 Anti notch-1 antibodies

Publications (2)

Publication Number Publication Date
MX2011013717A MX2011013717A (es) 2012-05-29
MX337468B true MX337468B (es) 2016-03-02

Family

ID=42575817

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011013717A MX337468B (es) 2009-06-18 2010-06-16 Anticuerpos anti notch-1.

Country Status (17)

Country Link
US (1) US9090690B2 (es)
EP (2) EP3431501A1 (es)
JP (2) JP6059985B2 (es)
KR (1) KR101570898B1 (es)
CN (1) CN102686610A (es)
AU (1) AU2010261364B2 (es)
BR (1) BRPI1011805A2 (es)
CA (1) CA2765989C (es)
CO (1) CO6480924A2 (es)
IL (1) IL217066A0 (es)
MX (1) MX337468B (es)
NZ (1) NZ597611A (es)
PE (1) PE20121494A1 (es)
RU (1) RU2011151287A (es)
SG (1) SG176731A1 (es)
WO (1) WO2010146550A1 (es)
ZA (1) ZA201109282B (es)

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US8404239B2 (en) * 2008-10-01 2013-03-26 Genentech, Inc. Anti-Notch2 NRR antibodies
CA2765989C (en) 2009-06-18 2016-11-29 Pfizer Inc. Anti notch-1 antibodies
BR112012007252A2 (pt) * 2009-09-30 2020-08-11 Genentech Inc uso de um antagonista específico de notch3, anticorpo e método para identificar um câncer
JP6016800B2 (ja) * 2010-12-15 2016-10-26 ワイス・エルエルシー 抗ノッチ1抗体
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
CN104903351A (zh) 2012-11-07 2015-09-09 辉瑞公司 抗-notch3抗体及抗体-药物缀合物
CA2941733A1 (en) * 2014-03-07 2015-09-11 Oncomed Pharmaceuticals, Inc. Methods for treating cancer with notch1 antibodies
US9914774B2 (en) 2014-07-11 2018-03-13 Genentech, Inc. Notch pathway inhibition
US11026996B2 (en) * 2016-05-25 2021-06-08 The Trustees Of Columbia University In The City Of New York Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling
JP2019535250A (ja) * 2016-10-29 2019-12-12 ジェネンテック, インコーポレイテッド 抗mic抗体及び使用方法
WO2020045646A1 (ja) 2018-08-31 2020-03-05 Bloom Technology 株式会社 終末糖化産物に対する抗体およびその使用

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Also Published As

Publication number Publication date
AU2010261364B2 (en) 2015-05-07
AU2010261364A1 (en) 2012-01-19
CA2765989A1 (en) 2010-12-23
CO6480924A2 (es) 2012-07-16
JP2016121162A (ja) 2016-07-07
JP2012530487A (ja) 2012-12-06
BRPI1011805A2 (pt) 2016-10-11
EP3431501A1 (en) 2019-01-23
KR20120071379A (ko) 2012-07-02
MX2011013717A (es) 2012-05-29
CN102686610A (zh) 2012-09-19
JP6059985B2 (ja) 2017-01-11
CA2765989C (en) 2016-11-29
WO2010146550A1 (en) 2010-12-23
ZA201109282B (en) 2012-08-29
KR101570898B1 (ko) 2015-11-23
RU2011151287A (ru) 2013-07-27
EP2443151A1 (en) 2012-04-25
NZ597611A (en) 2014-03-28
IL217066A0 (en) 2012-02-29
SG176731A1 (en) 2012-01-30
US9090690B2 (en) 2015-07-28
US20120093813A1 (en) 2012-04-19
PE20121494A1 (es) 2012-11-01

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