PE20141109A1 - Anticuerpos anti-notch 1 - Google Patents
Anticuerpos anti-notch 1Info
- Publication number
- PE20141109A1 PE20141109A1 PE2013001423A PE2013001423A PE20141109A1 PE 20141109 A1 PE20141109 A1 PE 20141109A1 PE 2013001423 A PE2013001423 A PE 2013001423A PE 2013001423 A PE2013001423 A PE 2013001423A PE 20141109 A1 PE20141109 A1 PE 20141109A1
- Authority
- PE
- Peru
- Prior art keywords
- antibody
- seq
- referred
- variable region
- notch antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Abstract
REFERIDO A UN ANTICUERPO QUE SE LIGA A NOTCH1, QUE COMPRENDE: UNA REGION VARIABLE DE LA CADENA PESADA DE SEQ ID NO: 71 Y UNA REGION VARIABLE DE LA CADENA LIVIANA DE SEQ ID NO: 97. DICHO ANTICUERPO ES UNA MOLECULA DE IgA, IgD, IgE, IgG O IgM, O DERIVA DE ELLAS. REFERIDO ADEMAS A UN ACIDO NUCLEICO, A UN VECTOR, UNA CELULA HUESPED, UN PROCESO PARA PRODUCIR UN ANTICUERPO Y A UNA COMPOSICION FARMACEUTICA. DICHO ANTICUERPO ES UTIL PARA EL TRATAMIENTO DEL CANCER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42357810P | 2010-12-15 | 2010-12-15 | |
US201161552578P | 2011-10-28 | 2011-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20141109A1 true PE20141109A1 (es) | 2014-09-24 |
Family
ID=45444674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013001423A PE20141109A1 (es) | 2010-12-15 | 2011-12-09 | Anticuerpos anti-notch 1 |
Country Status (20)
Country | Link |
---|---|
US (2) | US9127060B2 (es) |
EP (1) | EP2651977A2 (es) |
JP (1) | JP6016800B2 (es) |
KR (2) | KR20150088334A (es) |
CN (2) | CN105884896A (es) |
AR (1) | AR084315A1 (es) |
AU (2) | AU2011342799B2 (es) |
BR (1) | BR112013015122A2 (es) |
CA (1) | CA2821130C (es) |
CO (1) | CO6791565A2 (es) |
HK (1) | HK1194388A1 (es) |
MX (1) | MX346995B (es) |
NZ (1) | NZ611785A (es) |
PE (1) | PE20141109A1 (es) |
PH (1) | PH12017500864A1 (es) |
RU (1) | RU2622083C2 (es) |
SA (1) | SA111330060B1 (es) |
SG (1) | SG191039A1 (es) |
TW (1) | TWI471333B (es) |
WO (1) | WO2012080926A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7919092B2 (en) | 2006-06-13 | 2011-04-05 | Oncomed Pharmaceuticals, Inc. | Antibodies to notch receptors |
SG174053A1 (en) | 2006-09-01 | 2011-09-29 | Therapeutic Human Polyclonals Inc | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
JP5618544B2 (ja) | 2007-01-24 | 2014-11-05 | オンコメッドファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
PE20121494A1 (es) | 2009-06-18 | 2012-11-01 | Pfizer | Anticuerpos anti notch-1 |
JP6016800B2 (ja) | 2010-12-15 | 2016-10-26 | ワイス・エルエルシー | 抗ノッチ1抗体 |
CA2885659A1 (en) * | 2012-09-21 | 2014-03-27 | Oncomed Pharmaceuticals, Inc. | Methods of treating hematological malignancies with notch1 antibodies |
WO2014072897A1 (en) | 2012-11-07 | 2014-05-15 | Pfizer Inc. | Anti-notch3 antibodies and antibody-drug conjugates |
WO2016007775A1 (en) | 2014-07-11 | 2016-01-14 | Genentech, Inc. | Notch pathway inhibition |
WO2016069906A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
SG10202006332PA (en) * | 2015-10-29 | 2020-08-28 | Hoffmann La Roche | Transgenic rabbit with common light chain |
CN105585636B (zh) * | 2015-11-24 | 2020-03-03 | 南方医科大学 | 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用 |
WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
EP3774867A1 (en) * | 2018-04-10 | 2021-02-17 | Stichting Sanquin Bloedvoorziening | Chimeric notch receptors |
KR102499678B1 (ko) * | 2020-02-27 | 2023-02-15 | 주식회사 베르티스 | 암의 진단용 조성물 |
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US20110286916A1 (en) | 2008-11-20 | 2011-11-24 | Jose Miguel Aste-Amezaga | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
PE20121494A1 (es) | 2009-06-18 | 2012-11-01 | Pfizer | Anticuerpos anti notch-1 |
KR101782180B1 (ko) | 2009-09-30 | 2017-10-23 | 제넨테크, 인크. | Notch3 길항제를 사용한 Notch1―길항제-내성 암(들)의 치료 |
AU2011205316B2 (en) | 2010-01-13 | 2015-05-28 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
JP6016800B2 (ja) | 2010-12-15 | 2016-10-26 | ワイス・エルエルシー | 抗ノッチ1抗体 |
WO2012080891A1 (en) | 2010-12-15 | 2012-06-21 | Rinat Neuroscience Corp. | Anti-notch-1 antibodies |
-
2011
- 2011-12-09 JP JP2013543934A patent/JP6016800B2/ja not_active Expired - Fee Related
- 2011-12-09 CN CN201610239070.1A patent/CN105884896A/zh active Pending
- 2011-12-09 AU AU2011342799A patent/AU2011342799B2/en not_active Ceased
- 2011-12-09 RU RU2013126494A patent/RU2622083C2/ru not_active IP Right Cessation
- 2011-12-09 NZ NZ61178511A patent/NZ611785A/en not_active IP Right Cessation
- 2011-12-09 CN CN201180067647.0A patent/CN103547594B/zh not_active Expired - Fee Related
- 2011-12-09 KR KR1020157019740A patent/KR20150088334A/ko not_active Application Discontinuation
- 2011-12-09 WO PCT/IB2011/055595 patent/WO2012080926A2/en active Application Filing
- 2011-12-09 EP EP11804819.8A patent/EP2651977A2/en not_active Withdrawn
- 2011-12-09 PE PE2013001423A patent/PE20141109A1/es not_active Application Discontinuation
- 2011-12-09 KR KR1020137018236A patent/KR101580726B1/ko not_active IP Right Cessation
- 2011-12-09 CA CA2821130A patent/CA2821130C/en not_active Expired - Fee Related
- 2011-12-09 BR BR112013015122A patent/BR112013015122A2/pt not_active IP Right Cessation
- 2011-12-09 US US13/994,349 patent/US9127060B2/en active Active
- 2011-12-09 MX MX2013006875A patent/MX346995B/es active IP Right Grant
- 2011-12-09 SG SG2013043724A patent/SG191039A1/en unknown
- 2011-12-14 TW TW100146256A patent/TWI471333B/zh not_active IP Right Cessation
- 2011-12-14 SA SA111330060A patent/SA111330060B1/ar unknown
- 2011-12-15 AR ARP110104711 patent/AR084315A1/es unknown
-
2013
- 2013-07-04 CO CO13158445A patent/CO6791565A2/es active IP Right Grant
-
2014
- 2014-07-28 HK HK14107668.0A patent/HK1194388A1/zh not_active IP Right Cessation
-
2015
- 2015-07-24 US US14/808,340 patent/US20160002331A1/en not_active Abandoned
-
2016
- 2016-08-26 AU AU2016219704A patent/AU2016219704A1/en not_active Abandoned
-
2017
- 2017-05-10 PH PH12017500864A patent/PH12017500864A1/en unknown
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