MX352338B - Anticuerpos neutralizantes del virus de la influenza a y usos de estos. - Google Patents

Anticuerpos neutralizantes del virus de la influenza a y usos de estos.

Info

Publication number
MX352338B
MX352338B MX2014000749A MX2014000749A MX352338B MX 352338 B MX352338 B MX 352338B MX 2014000749 A MX2014000749 A MX 2014000749A MX 2014000749 A MX2014000749 A MX 2014000749A MX 352338 B MX352338 B MX 352338B
Authority
MX
Mexico
Prior art keywords
influenza
antibodies
subtype
epitopes
neutralizing anti
Prior art date
Application number
MX2014000749A
Other languages
English (en)
Other versions
MX2014000749A (es
Inventor
Antonio Lanzavecchia
Original Assignee
Inst Res Biomedicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Res Biomedicine filed Critical Inst Res Biomedicine
Publication of MX2014000749A publication Critical patent/MX2014000749A/es
Publication of MX352338B publication Critical patent/MX352338B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Abstract

La presente invención se refiere a anticuerpos y fragmentos de unión a antígeno de éstos, que se unen específicamente a un epítopo en la región del tallo de un trímero de hemaglutinina de la influenza A y neutralizan un subtipo del grupo 1 y un subtipo del grupo 2 del virus de la influenza A; ácidos nucleicos que codifican células B inmortalizadas y células plasmáticas individuales cultivadas que producen, y epítopos que se unen a tales anticuerpos y fragmentos de anticuerpo; además, el uso de los anticuerpos, fragmentos de anticuerpo y epítopos en métodos de selección, así como en el diagnóstico, tratamiento y prevención de la infección por el virus de la influenza A.
MX2014000749A 2011-07-18 2011-07-18 Anticuerpos neutralizantes del virus de la influenza a y usos de estos. MX352338B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2011/002329 WO2013011347A1 (en) 2011-07-18 2011-07-18 Neutralizing anti-influenza a virus antibodies and uses thereof

Publications (2)

Publication Number Publication Date
MX2014000749A MX2014000749A (es) 2014-05-07
MX352338B true MX352338B (es) 2017-11-17

Family

ID=44993618

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000749A MX352338B (es) 2011-07-18 2011-07-18 Anticuerpos neutralizantes del virus de la influenza a y usos de estos.

Country Status (15)

Country Link
US (3) US9587010B2 (es)
EP (3) EP2734545B1 (es)
JP (1) JP6035332B2 (es)
CN (1) CN103717617B (es)
AU (1) AU2011373387B2 (es)
CA (1) CA2841551C (es)
DK (2) DK3418300T3 (es)
ES (2) ES2841899T3 (es)
HR (2) HRP20190714T1 (es)
HU (2) HUE051756T2 (es)
LT (2) LT2734545T (es)
MX (1) MX352338B (es)
PL (2) PL2734545T3 (es)
SI (2) SI2734545T1 (es)
WO (1) WO2013011347A1 (es)

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Publication number Publication date
HUE044089T2 (hu) 2019-09-30
DK3418300T3 (da) 2020-12-07
CA2841551C (en) 2020-07-28
US20190248874A1 (en) 2019-08-15
CA2841551A1 (en) 2013-01-24
HRP20201975T1 (hr) 2021-02-05
LT3418300T (lt) 2021-01-11
SI3418300T1 (sl) 2021-03-31
EP3812397A1 (en) 2021-04-28
PL3418300T3 (pl) 2021-05-04
ES2732552T3 (es) 2019-11-25
JP2014523254A (ja) 2014-09-11
HRP20190714T1 (hr) 2019-06-14
PL2734545T3 (pl) 2019-09-30
SI2734545T1 (sl) 2019-06-28
MX2014000749A (es) 2014-05-07
ES2841899T3 (es) 2021-07-12
US10815294B2 (en) 2020-10-27
AU2011373387A1 (en) 2014-01-23
EP3418300B1 (en) 2020-10-28
US20140271655A1 (en) 2014-09-18
EP2734545B1 (en) 2019-03-27
EP2734545A1 (en) 2014-05-28
WO2013011347A1 (en) 2013-01-24
HUE051756T2 (hu) 2021-03-29
US20170204167A1 (en) 2017-07-20
AU2011373387B2 (en) 2017-06-29
DK2734545T3 (en) 2019-04-15
CN103717617B (zh) 2017-06-20
CN103717617A (zh) 2014-04-09
US9587010B2 (en) 2017-03-07
EP3418300A1 (en) 2018-12-26
JP6035332B2 (ja) 2016-11-30
LT2734545T (lt) 2019-05-10

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