HRP20201975T1 - Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba - Google Patents
Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba Download PDFInfo
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- HRP20201975T1 HRP20201975T1 HRP20201975TT HRP20201975T HRP20201975T1 HR P20201975 T1 HRP20201975 T1 HR P20201975T1 HR P20201975T T HRP20201975T T HR P20201975TT HR P20201975 T HRP20201975 T HR P20201975T HR P20201975 T1 HRP20201975 T1 HR P20201975T1
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- 206010022000 influenza Diseases 0.000 title claims 3
- 241000700605 Viruses Species 0.000 title 1
- 230000003472 neutralizing effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 241000712431 Influenza A virus Species 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (11)
1. Izolirano protutijelo, ili njegov ulomak koji veže antigen, koje neutralizira infekciju podskupa grupe 1 i podskupa grupe 2 virusa influence A i obuhvaća: (i) sekvence CDR1, CDR2 i CDR3 teškog lanca kao što je navedeno u SEQ ID NOs: 1, 41 i 43, redom, ili kao što je navedeno u SEQ ID NOs: 1, 41 i 42, redom; i (ii) sekvence CDR1, CDR2, i CDR3 lakog lanca kako je navedeno u SEQ ID NOs: 4, 5 i 6, redom, ili kao što je navedeno u SEQ ID NOs: 44, 5 i 6, redom,
pri čemu se navedeno protutijelo, ili njegov ulomak koji veže antigen, proizvodi u transfektiranim stanicama u titrima najmanje 3 puta višim od titra u kojem se proizvodi FI6 varijanta 2.
2. Protutijelo prema zahtjevu 1, ili njegov ulomak koji veže antigen, naznačeno time što sadrži varijabilnu regiju teškog lanca koja ima najmanje 80% identičnosti sekvence sa sekvencom aminokiseline kao što je navedeno u SEQ ID NOs: 59 ili 55; i varijabilnu regiju lakog lanca koja ima najmanje 80% identičnosti sekvence sa sekvencom aminokiseline kao što je navedeno u SEQ ID NOs: 57 ili 61.
3. Izolirano protutijelo, ili njegov ulomak koji veže antigen, naznačeno time što sadrži varijabilnu regiju teškog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 59 i varijabilnu regiju lakog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 57; ili varijabilnu regiju teškog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 59 i varijabilnu regiju lakog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 61; ili varijabilnu regiju teškog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 55 i varijabilnu regiju lakog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 57; ili varijabilnu regiju teškog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 55 i varijabilnu regiju lakog lanca koja sadrži sekvencu aminokiseline SEQ ID NO: 61, i pri čemu protutijelo neutralizira podskup grupe 1 i podskup grupe 2 virusa influence A.
4. Protutijelo prema bilo kojem od prethodnih zahtjeva, ili njegov ulomak koji veže antigen, naznačeno time što je protutijelo ljudsko protutijelo, monoklonsko protutijelo, pročišćeno protutijelo, jednolančano protutijelo, Fab, Fab', F(ab')2, Fv ili scFv.
5. Protutijelo prema bilo kojem od prethodnih zahtjeva, ili njegov ulomak koji veže antigen, naznačeno time što je za uporabu u liječenju infekcije virusom influence A.
6. Molekula nukleinske kiseline naznačena time što sadrži polinukleotid koji kodira protutijelo, ili njegov ulomak koji veže antigen, prema bilo kojem od prethodnih zahtjeva.
7. Vektor naznačen time što sadrži molekulu nukleinske kiseline iz zahtjeva 6.
8. Stanica naznačena time što eksprimira protutijelo prema bilo kojem od patentnih zahtjeva 1 - 4, ili njegov ulomak koji veže antigen; ili sadrži vektor prema zahtjevu 7.
9. Farmaceutski pripravak naznačen time što sadrži protutijelo prema bilo kojem od patentnih zahtjeva 1 - 4, ili njegov ulomak koji veže antigen, nukleinsku kiselinu prema zahtjevu 6, vektor prema zahtjevu 7, ili stanicu prema zahtjevu 8, i farmaceutski prihvatljivo sredstvo za razrjeđivanje ili nosač.
10. Protutijelo prema bilo kojem od patentnih zahtjeva 1 -4, ili njegov ulomak koji veže antigen, nukleinsku kiselinu prema zahtjevu 6, vektor prema zahtjevu 7, stanicu prema zahtjevu 8, ili farmaceutski pripravak prema zahtjevu 9 (i) za uporabu kao lijek za liječenje infekcije virusom influence, (ii) u cjepivu, ili (iii) u dijagnostici infekcije virusom influence A.
11. Uporaba protutijela prema bilo kojem od zahtjeva 1 -4, ili njegovog ulomka koji veže antigen, naznačena time što je za praćenje kvalitete cjepiva protiv virusa influence A provjerom da li antigen navedenog cjepiva sadrži specifični epitop u ispravnoj konformaciji.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2011/002329 WO2013011347A1 (en) | 2011-07-18 | 2011-07-18 | Neutralizing anti-influenza a virus antibodies and uses thereof |
| EP18180926.0A EP3418300B1 (en) | 2011-07-18 | 2011-07-18 | Neutralizing anti-influenza a virus antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201975T1 true HRP20201975T1 (hr) | 2021-02-05 |
Family
ID=44993618
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190714TT HRP20190714T1 (hr) | 2011-07-18 | 2019-04-16 | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba |
| HRP20201975TT HRP20201975T1 (hr) | 2011-07-18 | 2020-12-10 | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190714TT HRP20190714T1 (hr) | 2011-07-18 | 2019-04-16 | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9587010B2 (hr) |
| EP (3) | EP3812397A1 (hr) |
| JP (1) | JP6035332B2 (hr) |
| CN (1) | CN103717617B (hr) |
| AU (1) | AU2011373387B2 (hr) |
| CA (1) | CA2841551C (hr) |
| DK (2) | DK3418300T3 (hr) |
| ES (2) | ES2732552T3 (hr) |
| HR (2) | HRP20190714T1 (hr) |
| HU (2) | HUE044089T2 (hr) |
| LT (2) | LT2734545T (hr) |
| MX (1) | MX352338B (hr) |
| PL (2) | PL3418300T3 (hr) |
| SI (2) | SI3418300T1 (hr) |
| WO (1) | WO2013011347A1 (hr) |
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| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
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- 2011-07-18 WO PCT/IB2011/002329 patent/WO2013011347A1/en active Application Filing
- 2011-07-18 EP EP20200200.2A patent/EP3812397A1/en active Pending
- 2011-07-18 CN CN201180072356.0A patent/CN103717617B/zh active Active
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- 2011-07-18 MX MX2014000749A patent/MX352338B/es active IP Right Grant
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