HRP20201505T1 - Široko neutralizirajuća anti-hiv protutijela - Google Patents
Široko neutralizirajuća anti-hiv protutijela Download PDFInfo
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- HRP20201505T1 HRP20201505T1 HRP20201505TT HRP20201505T HRP20201505T1 HR P20201505 T1 HRP20201505 T1 HR P20201505T1 HR P20201505T T HRP20201505T T HR P20201505TT HR P20201505 T HRP20201505 T HR P20201505T HR P20201505 T1 HRP20201505 T1 HR P20201505T1
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- 230000036436 anti-hiv Effects 0.000 title claims 9
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 210000004748 cultured cell Anatomy 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 1
- 229940124411 anti-hiv antiviral agent Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (9)
1. Izolirano anti-HIV protutijelo, ili njegov dio koji veže antigen, koje sadrži CDRH 1, CDRH 2, CDRH 3, CDRL 1, CDRL 2 i CDRL 3, naznačeno time što CDRH 1, CDRH 2, CDRH 3, CDRL 1, CDRL 2 i CDRL 3 sadrže odgovarajuće sekvence skupa CDR odabrane iz skupine koja sadrži SEQ ID Nos: 69-74, SEQ ID NOs: 57-62, SEQ ID NOs: 63-68, SEQ ID NOs: 87-92, i SEQ ID NOs: 93- 98.
2. Izolirano anti-HIV protutijelo, ili njegov dio koji veže antigen, prema patentnom zahtjevu 1, naznačeno time što teški lanac i laki lanac sadrže odgovarajuće sekvence para teških / lakih lanaca odabranih iz skupine SEQ ID NOs: 13-14, SEQ ID NOs: 9-10, SEQ ID NOs: 11-12,SEQ ID NOs: 19-20, i SEQ ID NOs: 21- 22.
3. Izolirano anti-HIV protutijelo ili njegov dio koji veže antigen prema patentnom zahtjevu 1, naznačeno time što je protutijelo ljudsko protutijelo.
4. Izolirana nukleinska kiselina naznačena time što sadrži sekvencu koji kodira anti-HIV protutijelo ili njegov dio koji veže antigen, prema bilo kojem od patentnih zahtjeva 1-3.
5. Vektor ili kultivirana stanica naznačena time što sadrži nukleinsku kiselinu prema patentnom zahtjevu 4.
6. Farmaceutski pripravak naznačen time što sadrži (i) najmanje jedno anti-HIV protutijelo ili njegov dio koji veže antigen, prema bilo kojem od patentnih zahtjeva 1-3, i (ii) farmaceutski prihvatljiv nosač.
7. Pripravak koji sadrži najmanje jedno anti-HIV protutijelo, ili njegov dio koji veže antigen, prema bilo kojem od zahtjeva 1-3 naznačen time da se upotrebljava u prevenciji ili liječenju HIV infekcije.
8. Postupak za dobivanje anti-HIV protutijela ili njegovog ulomka, koji obuhvaća
dobivanje kultivirane stanice prema zahtjevu 5; kultiviranje stanice u mediju u uvjetima koji omogućuju ekspresiju polipeptida kodiranog vektorom i sastavljanje protutijela ili njegovog ulomka i pročišćavanje protutijela ili ulomka iz uzgojene stanice ili staničnog medija.
9. Komplet koji sadrži farmaceutski prihvatljivu doznu jedinicu farmaceutski učinkovite količine najmanje jednog izoliranog anti-HIV protutijela prema bilo kojem od patentnih zahtjeva 1-3, i farmaceutski prihvatljivu doznu jedinicu farmaceutski učinkovite količine sredstva protiv HIV-a, pri čemu dvije farmaceutski prihvatljive dozne jedinice mogu izborno imati oblik jedne farmaceutski prihvatljive dozne jedinice.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261715642P | 2012-10-18 | 2012-10-18 | |
EP13847347.5A EP2908912B1 (en) | 2012-10-18 | 2013-10-18 | Broadly-neutralizing anti-hiv antibodies |
PCT/US2013/065696 WO2014063059A1 (en) | 2012-10-18 | 2013-10-18 | Broadly-neutralizing anti-hiv antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201505T1 true HRP20201505T1 (hr) | 2020-12-11 |
Family
ID=50488789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201505TT HRP20201505T1 (hr) | 2012-10-18 | 2020-09-21 | Široko neutralizirajuća anti-hiv protutijela |
Country Status (21)
Country | Link |
---|---|
US (5) | US10047146B2 (hr) |
EP (2) | EP3783018A1 (hr) |
JP (5) | JP6461804B2 (hr) |
CN (1) | CN104918658B (hr) |
AU (4) | AU2013331049B2 (hr) |
BR (1) | BR112015008635B1 (hr) |
CA (2) | CA3236192A1 (hr) |
CY (1) | CY1124405T1 (hr) |
DK (1) | DK2908912T3 (hr) |
EA (2) | EA035012B1 (hr) |
ES (1) | ES2822135T3 (hr) |
HK (1) | HK1212935A1 (hr) |
HR (1) | HRP20201505T1 (hr) |
HU (1) | HUE051577T2 (hr) |
IL (4) | IL285049B (hr) |
LT (1) | LT2908912T (hr) |
MX (2) | MX2015004924A (hr) |
PL (1) | PL2908912T3 (hr) |
PT (1) | PT2908912T (hr) |
SI (1) | SI2908912T1 (hr) |
WO (1) | WO2014063059A1 (hr) |
Families Citing this family (60)
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