HRP20210375T1 - Virus ljudske imunodeficijencije neutraliziranja antitijela i postupci njegova korištenja - Google Patents
Virus ljudske imunodeficijencije neutraliziranja antitijela i postupci njegova korištenja Download PDFInfo
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- HRP20210375T1 HRP20210375T1 HRP20210375TT HRP20210375T HRP20210375T1 HR P20210375 T1 HRP20210375 T1 HR P20210375T1 HR P20210375T T HRP20210375T T HR P20210375TT HR P20210375 T HRP20210375 T HR P20210375T HR P20210375 T1 HRP20210375 T1 HR P20210375T1
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- Prior art keywords
- antibody
- antigen
- hiv
- binding fragment
- hiv antibody
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- 238000000034 method Methods 0.000 title claims 5
- 241000725303 Human immunodeficiency virus Species 0.000 title 1
- 230000003472 neutralizing effect Effects 0.000 title 1
- 230000036436 anti-hiv Effects 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
Claims (11)
1. Izolirano ljudsko anti-HIV antitijelo ili njegov fragment koji veže antigen, sastoji se od teškog lanca koji sadrži aminokiselinsku sekvencu QVQLLQSGAAVTKPGASVRVSCEASGYNIRDYFIHWWRQAPGQGLQWVGWINPKTGQPNNPRQFQGRVSLTRHASWDFDTFSFYMDLKALRSDDTAVYFCARQRSDYWDFDV i lakog lanca koji sadrži aminokiselinsku sekvencu
[image]
2. Izolirano ljudsko anti-HIV antitijelo ili fragment koji veže antigen prema zahtjevu 1 sadrži aminokiselinsku sekvencu SEQ ID NO: 387 i aminokiselinsku sekvencu SEQ ID NO: 558.
3. Pripravak koji sadrži izolirano anti-HIV antitijelo ili fragment koji veže antigen prema bilo kojem od zahtjeva 1-2.
4. Molekula nukleinske kiseline koja kodira izolirano anti-HIV antitijelo ili fragment koji veže antigen prema bilo kojem od zahtjeva 1-2.
5. Vektor koji sadrži molekulu nukleinske kiseline prema zahtjevu 4.
6. Stanica koja sadrži vektor prema zahtjevu 5.
7. Farmaceutski pripravak koji sadrži najmanje jedno antitijelo prema bilo kojem od zahtjeva 1-2 ili njegov fragment koji veže antigen i farmaceutski prihvatljiv nosač.
8. Postupak za izradu anti-HIV antitijela ili njegovog fragmenta koji veže antigen prema bilo kojem od zahtjeva 1-2, navedeni postupak obuhvaća uzgoj stanice koja sadrži vektor koji sadrži nukleinsku kiselinu koja kodira teški i laki lanac navedenog antitijela pod uvjetima u kojima se nukleinska kiselina eksprimira, i izolira navedeno anti-HIV antitijelo ili njegov fragment.
9. Postupak za otkrivanje anti-HIV antitijela prema bilo kojem od zahtjeva 1-2 kod pacijenta, navedeni postupak obuhvaća pružanje biološkog uzorka dobivenog od pacijenta i ispitivanje biološkog uzorka na prisutnost anti-HIV antitijela ili stanice koja sadrži barem jedan od DNA ili mRNA koji kodiraju antitijelo.
10. Terapeutski učinkovita količina najmanje jednog anti-HIV antitijela ili fragmenta koji veže antigen prema bilo kojem od zahtjeva 1-2 ili barem jednog anti-HIV antitijela, ili njegovog fragmenta, načinjena postupkom prema zahtjevu 8, za uporabu u prevenciji ili liječenju HIV infekcije ili bolesti povezane s HIV-om.
11. Terapeutski učinkovita količina antitijela ili fragmenta koji veže antigen za uporabu prema zahtjevu 10, za primjenu s drugim terapijskim sredstvom, pri čemu je navedeno drugo terapijsko sredstvo izborno antivirusno sredstvo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486960P | 2011-05-17 | 2011-05-17 | |
| EP12785929.6A EP2710033B1 (en) | 2011-05-17 | 2012-05-17 | Human immunodeficiency virus neutralizing antibodies and methods of use thereof |
| PCT/US2012/038400 WO2012158948A1 (en) | 2011-05-17 | 2012-05-17 | Human immunodeficiency virus neutralizing antibodies adn methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210375T1 true HRP20210375T1 (hr) | 2021-07-09 |
Family
ID=47177348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210375TT HRP20210375T1 (hr) | 2011-05-17 | 2021-03-03 | Virus ljudske imunodeficijencije neutraliziranja antitijela i postupci njegova korištenja |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9783594B2 (hr) |
| EP (2) | EP3865507A1 (hr) |
| JP (5) | JP6323718B2 (hr) |
| CN (4) | CN106432484B (hr) |
| AU (5) | AU2012255266B2 (hr) |
| BR (1) | BR112013029550A2 (hr) |
| CA (1) | CA2836468C (hr) |
| CY (1) | CY1124043T1 (hr) |
| DK (1) | DK2710033T3 (hr) |
| EA (2) | EA201990685A1 (hr) |
| ES (1) | ES2895523T3 (hr) |
| HR (1) | HRP20210375T1 (hr) |
| HU (1) | HUE053545T2 (hr) |
| IL (4) | IL295205B1 (hr) |
| LT (1) | LT2710033T (hr) |
| MX (1) | MX358099B (hr) |
| PL (1) | PL2710033T3 (hr) |
| PT (1) | PT2710033T (hr) |
| SI (1) | SI2710033T1 (hr) |
| WO (1) | WO2012158948A1 (hr) |
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| WO2015103549A1 (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| WO2015117008A2 (en) | 2014-01-31 | 2015-08-06 | The Rockefeller University | Broadly neutralizing anti-hiv antibodies and epitope therefor |
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| US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
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