ATE175997T1 - Behandlung von zellpopulationen - Google Patents

Behandlung von zellpopulationen

Info

Publication number
ATE175997T1
ATE175997T1 AT92916742T AT92916742T ATE175997T1 AT E175997 T1 ATE175997 T1 AT E175997T1 AT 92916742 T AT92916742 T AT 92916742T AT 92916742 T AT92916742 T AT 92916742T AT E175997 T1 ATE175997 T1 AT E175997T1
Authority
AT
Austria
Prior art keywords
pct
copies
sec
treatment
cells
Prior art date
Application number
AT92916742T
Other languages
English (en)
Inventor
Michael Embleton
Guy Gorochov
Peter Thomas Jones
Gregory Paul Winter
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117352A external-priority patent/GB9117352D0/en
Priority claimed from GB929212419A external-priority patent/GB9212419D0/en
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE175997T1 publication Critical patent/ATE175997T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
AT92916742T 1991-08-10 1992-08-10 Behandlung von zellpopulationen ATE175997T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919117352A GB9117352D0 (en) 1991-08-10 1991-08-10 Recombinant dna method
GB929212419A GB9212419D0 (en) 1992-06-11 1992-06-11 Recombinant dna method

Publications (1)

Publication Number Publication Date
ATE175997T1 true ATE175997T1 (de) 1999-02-15

Family

ID=26299394

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92916742T ATE175997T1 (de) 1991-08-10 1992-08-10 Behandlung von zellpopulationen

Country Status (11)

Country Link
US (1) US5830663A (de)
EP (1) EP0597960B1 (de)
JP (1) JPH06509473A (de)
AT (1) ATE175997T1 (de)
AU (1) AU665365B2 (de)
CA (1) CA2114950A1 (de)
DE (1) DE69228247T2 (de)
DK (1) DK0597960T3 (de)
ES (1) ES2130177T3 (de)
GR (1) GR3029913T3 (de)
WO (1) WO1993003151A1 (de)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830713A (en) * 1986-11-04 1998-11-03 Protein Polymer Technologies, Inc. Methods for preparing synthetic repetitive DNA
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
GB9216983D0 (en) * 1992-08-11 1992-09-23 Unilever Plc Polypeptide production
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
ATE243745T1 (de) * 1994-01-31 2003-07-15 Univ Boston Bibliotheken aus polyklonalen antikörpern
GB9401815D0 (en) * 1994-01-31 1994-03-23 Ray Ronnie A A new method for combined intracellular reverse transciption and amplification
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
JP2002503954A (ja) 1997-04-01 2002-02-05 グラクソ、グループ、リミテッド 核酸増幅法
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DK1496120T3 (da) * 1997-07-07 2007-07-30 Medical Res Council In vitro-sorteringsmetode
ATE405649T1 (de) * 1998-05-08 2008-09-15 Sanquin Bloedvoorziening Hemmstoff zur diagnose und behandlung von haemophilia a patienten
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
JP2003524389A (ja) 1998-12-16 2003-08-19 カイロン コーポレイション ヒトサイクリン依存的キナーゼ(hPNQALRE)
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
AU4032300A (en) * 1999-03-24 2000-10-09 Gene Therapy Systems, Inc. Method for generating transcriptionally active dna fragments
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
AU2001232204A1 (en) * 2000-02-22 2001-09-03 Ahuva Nissim Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
US6211164B1 (en) * 2000-03-10 2001-04-03 Abbott Laboratories Antisense oligonucleotides of the human chk1 gene and uses thereof
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
EP2199393B1 (de) * 2000-04-17 2012-10-31 Dyax Corp. Verfahren zur Einrichtung von Bibliotheken für genetische Verpackungen unterschiedlicher Familien von Peptiden
GB0022458D0 (en) * 2000-09-13 2000-11-01 Medical Res Council Directed evolution method
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
US20050196755A1 (en) * 2000-11-17 2005-09-08 Maurice Zauderer In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
CN1306272C (zh) * 2000-11-17 2007-03-21 罗切斯特大学 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的方法
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
DK1360288T3 (da) * 2000-12-18 2011-06-14 Dyax Corp Fokuserede biblioteker af genetiske pakker
WO2002086096A2 (en) * 2001-01-23 2002-10-31 University Of Rochester Medical Center Methods of producing or identifying intrabodies in eukaryotic cells
WO2002070678A2 (en) 2001-02-05 2002-09-12 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
EP1365034A3 (de) 2002-05-21 2004-02-18 Bayer HealthCare AG Verfahren und Zusammensetzungen zur Vorhersage, Diagnose, Prognose, Prävention und Behandlung von malignen Tumoren
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US20040224325A1 (en) * 2002-12-20 2004-11-11 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA
US7244567B2 (en) 2003-01-29 2007-07-17 454 Life Sciences Corporation Double ended sequencing
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
PL1644493T3 (pl) 2003-06-27 2010-11-30 Axikin Pharmaceuticals Inc Regulacja kinazy regulowanej w COPD (kinaza RC)
EP1641809B2 (de) 2003-07-05 2018-10-03 The Johns Hopkins University Verfahren und zusammensetzungen zum nachweis und zur auflistung genetischer variationen
ATE461292T1 (de) * 2003-09-10 2010-04-15 Althea Technologies Inc Erstellung von expressionsprofilen unter verwendung von mikroarrays
TWI333977B (en) 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
KR101135134B1 (ko) * 2003-09-18 2012-04-13 심포젠 에이/에스 관심있는 서열을 결합시키는 방법
EP1892306A3 (de) 2003-10-06 2008-06-11 Bayer HealthCare AG Verfahren und Kit zur Untersuchung von Krebs
WO2005049787A2 (en) * 2003-11-24 2005-06-02 Yeda Research And Development Co.Ltd. Compositions and methods for in vitro sorting of molecular and cellular libraries
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20070286854A1 (en) 2004-04-28 2007-12-13 Bayer Healthcare Ag Diagnostics And Therapeutics For Diseases Associated With Dipeptidyl-Peptidase 1 (Dpp1)
GB0418651D0 (en) * 2004-08-20 2004-09-22 Medical Res Council Method
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP2239342A3 (de) 2005-02-01 2010-11-03 AB Advanced Genetic Analysis Corporation Reagentien, Verfahren und Bibliotheken zur Sequenzierung mit Kügelchen
EP2236628A3 (de) 2005-02-01 2010-10-13 AB Advanced Genetic Analysis Corporation Reagentien, Verfahren und Bibliotheken zur Sequenzierung mit Kügelchen
US20060281108A1 (en) * 2005-05-03 2006-12-14 Althea Technologies, Inc. Compositions and methods for the analysis of degraded nucleic acids
WO2007081386A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
US20080287857A1 (en) * 2006-02-11 2008-11-20 Rune Kjeken Device and method for single-needle in vivo electroporation
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
CN101370553B (zh) * 2006-02-11 2013-04-10 基因特伦尼克斯公司 用于单针体内电穿孔的装置和方法
US20070231823A1 (en) * 2006-03-23 2007-10-04 Mckernan Kevin J Directed enrichment of genomic DNA for high-throughput sequencing
EP2019687B1 (de) 2006-03-29 2014-03-19 Merial Limited Impfstoff gegen streptokokken
JP2009538123A (ja) * 2006-04-19 2009-11-05 アプライド バイオシステムズ, エルエルシー ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
JP2010506136A (ja) 2006-05-11 2010-02-25 レインダンス テクノロジーズ, インコーポレイテッド 微小流体デバイス
EP2029781A4 (de) * 2006-05-26 2010-06-30 Althea Technologies Inc Biochemische analyse partitionierter zellen
EP3536396B1 (de) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
EP2121983A2 (de) 2007-02-02 2009-11-25 Illumina Cambridge Limited Verfahren zur kennzeichnung von proben und sequenzierung mehrerer nukleotidmatrizen
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
AU2008221119B2 (en) 2007-03-01 2013-11-14 Les Laboratoires Servier Method for cloning cognate antibodies
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US7883265B2 (en) * 2007-06-01 2011-02-08 Applied Biosystems, Llc Devices, systems, and methods for preparing emulsions
CA2694990A1 (en) * 2007-07-31 2009-02-05 Merck Sharp & Dohme Corp. Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
JP5653215B2 (ja) 2007-09-12 2015-01-14 ノバルティス アーゲー Gas57変異体抗原およびgas57抗体
EP2193146B1 (de) 2007-09-14 2016-05-25 Adimab, LLC Synthetische antikörperbibliotheken mit rationalem design und ihre verwendung
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP2010539982A (ja) * 2007-10-01 2010-12-24 アプライド バイオシステムズ, エルエルシー チェイスライゲーション配列決定法
EP2235046B1 (de) 2007-12-21 2012-08-01 Novartis AG Mutierte formen von streptolysin o
US8211673B2 (en) 2008-02-04 2012-07-03 Life Technologies Corporation Composition and method for sequencing nucleic acid
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
US8143007B2 (en) * 2008-03-13 2012-03-27 National Institute Of Immunology Nested primer sets for amplifying mouse immunoglobulin variable gene segments
CA2722409C (en) 2008-04-24 2017-12-12 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
US8728764B2 (en) 2008-10-02 2014-05-20 Illumina Cambridge Limited Nucleic acid sample enrichment for sequencing applications
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
BRPI1011195B1 (pt) 2009-05-20 2020-10-13 Novimmune S.A métodos para produzir uma coleção de ácidos nucleicos
SG175407A1 (en) 2009-05-29 2011-11-28 Morphosys Ag A collection and methods for its use
EP3020412B1 (de) 2009-06-16 2017-10-11 The Regents of the University of Michigan Nanoemulsionsimpfstoffe
AU2010291902A1 (en) * 2009-09-14 2012-04-05 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP3392349A1 (de) 2010-02-12 2018-10-24 Raindance Technologies, Inc. Digitale analyse von analyten
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
RS57937B1 (sr) 2010-05-14 2019-01-31 Alltech Inc Komponente ćelijskog zida kvasca i njihova detekcija
US9354228B2 (en) 2010-07-16 2016-05-31 Adimab, Llc Antibody libraries
CA2808118C (en) 2010-07-22 2016-04-19 Kieran Curran Composite liquid cells
EP3447155A1 (de) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwichassays in tröpfchen
CN103270174B (zh) 2010-10-28 2016-08-24 生命技术公司 化学增强型引物组合物、方法和试剂盒
KR101938021B1 (ko) 2010-11-19 2019-01-11 모르포시스 아게 집합 및 집합의 이용방법
US20140057799A1 (en) 2010-12-16 2014-02-27 Gigagen System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells
EP3604339B1 (de) 2011-01-14 2021-03-10 The Regents Of The University Of California Therapeutische antikörper gegen das ror-1-protein und verfahren zur verwendung davon
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US20140090094A1 (en) 2011-03-09 2014-03-27 Bayer Intellectual Property Gmbh Modulators of slc22a7
SI3415619T1 (sl) 2011-04-28 2021-04-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170, Third Floor, Main Quad Identifikacija polinukleotidov, povezanih z vzorcem
DK2710033T3 (da) 2011-05-17 2021-03-08 Univ Rockefeller Human immundefektvirus-neutraliserende antistoffer og fremgangsmåder til anvendelse deraf
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3709018A1 (de) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
RU2732151C2 (ru) 2011-09-30 2020-09-11 Чугаи Сейяку Кабусики Кайся Библиотека зависимых от концентрации ионов связывающих молекул
EP2612916A1 (de) 2012-01-09 2013-07-10 Universität Zürich Zellverkapselung mit hohem Durchsatz für Screening oder Auswahl
CN104334725A (zh) 2012-01-25 2015-02-04 基因细胞生物系统有限公司 生物分子分离
EP2626433B1 (de) 2012-02-09 2017-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zum Koppeln von Nukleinsäuren in einem Mikrosom aus den endoplasmatischen Retikuli.
US9388465B2 (en) 2013-02-08 2016-07-12 10X Genomics, Inc. Polynucleotide barcode generation
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN114891871A (zh) * 2012-08-14 2022-08-12 10X基因组学有限公司 微胶囊组合物及方法
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20150090037A (ko) 2012-11-27 2015-08-05 젠셀 바이오시스템즈 리미티드 액체 샘플의 취급
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (de) 2012-12-14 2019-11-13 10X Genomics, Inc. Verfahren und systeme zur verarbeitung von polynukleotiden
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
EP3105326A4 (de) 2014-02-10 2018-01-10 Gencell Biosystems Limited Vorrichtung zur herstellung einer clc-vermittelten nukleinsäurenbibliothek und verfahren zur verwendung davon
US9694361B2 (en) 2014-04-10 2017-07-04 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
CN105085673B (zh) * 2014-05-19 2018-09-11 厦门大学 用于检测柯萨奇病毒a16型病毒实心颗粒的单克隆抗体及其用途
CN113249435A (zh) 2014-06-26 2021-08-13 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
EP3201356A1 (de) 2014-10-03 2017-08-09 Life Technologies Corporation Genetische sequenzüberprüfungszusammensetzungen, verfahren und kits
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
US9422547B1 (en) 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
EP3529596A4 (de) 2016-11-11 2020-05-13 Ascendant DX, LLC Zusammensetzungen und verfahren zur diagnose und differenzierung von systemischer juveniler idiopathischer arthritis und morbus kawasaki
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN117512066A (zh) 2017-01-30 2024-02-06 10X基因组学有限公司 用于基于微滴的单细胞条形编码的方法和系统
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3765054A4 (de) * 2018-01-19 2022-01-12 The Trustees Of The University Of Pennsylvania Zusammensetzungen und verfahren zum targeting von gamma-delta-t-zellen mit chimären antigenrezeptoren
EP3775271A1 (de) 2018-04-06 2021-02-17 10X Genomics, Inc. Systeme und verfahren zur qualitätskontrolle in einer einzelzellenverarbeitung
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11929171B2 (en) 2018-10-18 2024-03-12 The Board Of Trustees Of The Leland Stanford Junior University Methods for evaluation and treatment of glycemic dysregulation and atherosclerotic cardiovascular disease and applications thereof
WO2020191365A1 (en) 2019-03-21 2020-09-24 Gigamune, Inc. Engineered cells expressing anti-viral t cell receptors and methods of use thereof
CN114107449B (zh) * 2020-08-31 2024-04-09 中山大学孙逸仙纪念医院 一种单细胞内原位qPCR方法
WO2024050450A1 (en) 2022-08-31 2024-03-07 Gigamune, Inc. Engineered enveloped vectors and methods of use thereof
CN116590283B (zh) * 2023-07-17 2023-11-07 北京微岩医疗器械有限公司 一种细胞结合增强剂和去除人源游离核酸的方法

Also Published As

Publication number Publication date
US5830663A (en) 1998-11-03
AU665365B2 (en) 1996-01-04
CA2114950A1 (en) 1993-02-11
GR3029913T3 (en) 1999-07-30
JPH06509473A (ja) 1994-10-27
ES2130177T3 (es) 1999-07-01
WO1993003151A1 (en) 1993-02-18
DE69228247T2 (de) 1999-07-08
DK0597960T3 (da) 1999-09-13
AU2400192A (en) 1993-03-02
DE69228247D1 (de) 1999-03-04
EP0597960A1 (de) 1994-05-25
EP0597960B1 (de) 1999-01-20

Similar Documents

Publication Publication Date Title
ATE175997T1 (de) Behandlung von zellpopulationen
DE69834267D1 (de) Gentherapeutische verfahren zur bereitstellung von apolipoprotein a-i agonisten sowie deren verwendung zur behandlung dyslipidämischer erkrankungen
ATE266723T1 (de) Lösung die chaotropische mittel enthält und verwendung dieser lösung in verfahren zur isolierung von dna, rna und proteinen
BR1100909A (pt) Oligonucleotìdeo
DE69333747D1 (de) Rekombinante zelle, dna-konstruktionen, vektoren und methoden zur expression von phytatabbauenden enzymen in gewünschten verhältnissen
DE69932599D1 (de) Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten
DE69831007D1 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
DE59309183D1 (de) Simultane sequenzierung von nukleinsäuren
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
ATE251886T1 (de) Verwendunf von apoe zum binden von tau und map2c proteinen und zur behandlung von alzheimer's krankheit
ATE360688T1 (de) Dna-fragment, dieses enthaltender rekombinanter vektor und verfahren zur expression von fremdgenen unter dessen verwendung
DE69510356D1 (de) Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie
ATE316138T1 (de) Rekombinante expression von s-layer-proteinen
DE69613685D1 (de) D-aminosäure-oxidase kodierendes dns-fragment
ATE317021T1 (de) Antisense modulierung von lfa-3
KR910004802A (ko) 긴팔원숭이 백혈병 비루스 리셉터 단백질, 이를 암호화하는 단리된 정제 dna 서열 및 이들을 동정하는 방법
DE69739263D1 (de) Produktion von proteinen, dafür kodierende plasmide und organismen, die solche plasmide enthalten
Bootsma Defective DNA repair and cancer
DE69931754D1 (de) Nukleinsäurefragmente, rekombinante vektoren, welche diese enthalten und verfahren zum unterstützen der expression von strukturellen genen durch anwendung derselben
Goldschmidt et al. A macromolecular perspective on the material basis of evolution
ATE301189T1 (de) Neues verfahren zum nachweis von cryptosporidium
SE9701344D0 (sv) Transgenic, non-human animal with protein deficiency, cells derived therefrom, use of said animal and cells, and method of producing said transgenic animal

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee