ATE317021T1 - Antisense modulierung von lfa-3 - Google Patents
Antisense modulierung von lfa-3Info
- Publication number
- ATE317021T1 ATE317021T1 AT99913927T AT99913927T ATE317021T1 AT E317021 T1 ATE317021 T1 AT E317021T1 AT 99913927 T AT99913927 T AT 99913927T AT 99913927 T AT99913927 T AT 99913927T AT E317021 T1 ATE317021 T1 AT E317021T1
- Authority
- AT
- Austria
- Prior art keywords
- lfa
- antisense modulation
- treatment
- modulation
- diagnosis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/045,106 US6001651A (en) | 1998-03-20 | 1998-03-20 | Antisense modulation of LFA-3 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE317021T1 true ATE317021T1 (de) | 2006-02-15 |
Family
ID=21936028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99913927T ATE317021T1 (de) | 1998-03-20 | 1999-03-17 | Antisense modulierung von lfa-3 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6001651A (de) |
EP (1) | EP1064402B1 (de) |
JP (1) | JP3590585B2 (de) |
AT (1) | ATE317021T1 (de) |
AU (1) | AU3189199A (de) |
DE (1) | DE69929683D1 (de) |
WO (1) | WO1999047707A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6503754B1 (en) * | 2000-09-07 | 2003-01-07 | Isis Pharmaceuticals, Inc. | Antisense modulation of BH3 interacting domain death agonist expression |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
US20040006036A1 (en) * | 2000-04-12 | 2004-01-08 | Gmr, A Delaware Corporation | Silencing transcription by methylation |
RU2293573C2 (ru) * | 2000-06-08 | 2007-02-20 | Интерселл Аг | Иммуностимулирующие олигодезоксинуклеотиды |
US20110171296A1 (en) * | 2000-10-30 | 2011-07-14 | Biohit Oyj | Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine |
US7105657B2 (en) * | 2002-11-08 | 2006-09-12 | Board Of Regents Of The University Of Nebraska | Compositions and methods for inhibiting pancreatic cancer metastasis |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4956281A (en) * | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
US5185441A (en) * | 1988-08-26 | 1993-02-09 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing pi-linked lymphocyte function associated antigen-3 |
DE4008354A1 (de) * | 1990-03-15 | 1991-09-19 | Basf Ag | Neues protein, seine herstellung und verwendung |
WO1992004463A1 (de) * | 1990-09-04 | 1992-03-19 | Basf Aktiengesellschaft | Cd58 spezifischer monoklonaler antikörper und dessen verwendung |
AU660981B2 (en) * | 1991-03-12 | 1995-07-13 | Astellas Us Llc | CD2-binding domain of lymphocyte function associated antigen 3 |
WO1992016563A1 (en) * | 1991-03-12 | 1992-10-01 | Biogen, Inc. | Monoclonal antibodies recognizing lymphocyte function associated antigen-3 |
AU660312B2 (en) * | 1991-06-06 | 1995-06-22 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | LFA-3-like protein, derivatives thereof, genes thereof and processes for preparing the same |
ATE210454T1 (de) * | 1991-10-07 | 2001-12-15 | Biogen Inc | Verfahren zur verbesserung der toleranz für allotransplantaten und xenotransplantaten durch verabreichung eines lfa-3- oder cd2- bindungsproteins |
JPH07502496A (ja) * | 1991-10-07 | 1995-03-16 | バイオゲン インコーポレイテッド | Cd2/lfa−3相互作用の阻害剤を用いる抗原提示細胞による皮膚障害の予防または治療の方法 |
CZ283488B6 (cs) * | 1992-08-20 | 1998-04-15 | Schering Corporation | Farmaceutický prostředek obsahující IL-4 a/nebo IL-10 nebo protilátky proti IL-4 a IL-10, způsob jeho výroby a jeho použití |
SE9302738L (sv) * | 1993-08-25 | 1995-02-26 | Cito Trading Co | Anordning för kraftöverföring mellan räl för spårbundet fordon och fundament |
EP0773993A4 (de) * | 1994-08-19 | 2000-07-05 | Gen Hospital Corp | Gentechnisch veränderte schweine-zellen |
WO1996033217A1 (fr) * | 1995-04-19 | 1996-10-24 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Proteine d'adhesion de cellules, agent immunosuppresseur contenant cette proteine et agent immunosuppresseur renfermant des cellules ainsi induites |
JP4513988B2 (ja) * | 2006-01-25 | 2010-07-28 | 日本電気株式会社 | 起動信号検出回路 |
-
1998
- 1998-03-20 US US09/045,106 patent/US6001651A/en not_active Expired - Lifetime
-
1999
- 1999-03-17 AU AU31891/99A patent/AU3189199A/en not_active Abandoned
- 1999-03-17 JP JP2000536889A patent/JP3590585B2/ja not_active Expired - Fee Related
- 1999-03-17 WO PCT/US1999/005837 patent/WO1999047707A1/en active IP Right Grant
- 1999-03-17 EP EP99913927A patent/EP1064402B1/de not_active Expired - Lifetime
- 1999-03-17 DE DE69929683T patent/DE69929683D1/de not_active Expired - Lifetime
- 1999-03-17 AT AT99913927T patent/ATE317021T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU3189199A (en) | 1999-10-11 |
WO1999047707A1 (en) | 1999-09-23 |
EP1064402A4 (de) | 2003-06-11 |
EP1064402A1 (de) | 2001-01-03 |
EP1064402B1 (de) | 2006-02-01 |
JP3590585B2 (ja) | 2004-11-17 |
JP2002506658A (ja) | 2002-03-05 |
US6001651A (en) | 1999-12-14 |
DE69929683D1 (de) | 2006-04-13 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |