DE69929683D1 - Antisense modulierung von lfa-3 - Google Patents
Antisense modulierung von lfa-3Info
- Publication number
- DE69929683D1 DE69929683D1 DE69929683T DE69929683T DE69929683D1 DE 69929683 D1 DE69929683 D1 DE 69929683D1 DE 69929683 T DE69929683 T DE 69929683T DE 69929683 T DE69929683 T DE 69929683T DE 69929683 D1 DE69929683 D1 DE 69929683D1
- Authority
- DE
- Germany
- Prior art keywords
- lfa
- antisense modulation
- treatment
- modulation
- diagnosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/045,106 US6001651A (en) | 1998-03-20 | 1998-03-20 | Antisense modulation of LFA-3 |
PCT/US1999/005837 WO1999047707A1 (en) | 1998-03-20 | 1999-03-17 | Antisense modulation of lfa-3 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69929683D1 true DE69929683D1 (de) | 2006-04-13 |
Family
ID=21936028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69929683T Expired - Lifetime DE69929683D1 (de) | 1998-03-20 | 1999-03-17 | Antisense modulierung von lfa-3 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6001651A (de) |
EP (1) | EP1064402B1 (de) |
JP (1) | JP3590585B2 (de) |
AT (1) | ATE317021T1 (de) |
AU (1) | AU3189199A (de) |
DE (1) | DE69929683D1 (de) |
WO (1) | WO1999047707A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6503754B1 (en) * | 2000-09-07 | 2003-01-07 | Isis Pharmaceuticals, Inc. | Antisense modulation of BH3 interacting domain death agonist expression |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
US20040006036A1 (en) * | 2000-04-12 | 2004-01-08 | Gmr, A Delaware Corporation | Silencing transcription by methylation |
SK287689B6 (sk) | 2000-06-08 | 2011-06-06 | Intercell Ag | Použitie molekuly oligodeoxynukleovej kyseliny na výrobu imunostimulačnej farmaceutickej kompozície a farmaceutický prípravok |
US20110171296A1 (en) * | 2000-10-30 | 2011-07-14 | Biohit Oyj | Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine |
US7105657B2 (en) * | 2002-11-08 | 2006-09-12 | Board Of Regents Of The University Of Nebraska | Compositions and methods for inhibiting pancreatic cancer metastasis |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4956281A (en) * | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
US5185441A (en) * | 1988-08-26 | 1993-02-09 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing pi-linked lymphocyte function associated antigen-3 |
DE4008354A1 (de) * | 1990-03-15 | 1991-09-19 | Basf Ag | Neues protein, seine herstellung und verwendung |
WO1992004463A1 (de) * | 1990-09-04 | 1992-03-19 | Basf Aktiengesellschaft | Cd58 spezifischer monoklonaler antikörper und dessen verwendung |
US5547853A (en) * | 1991-03-12 | 1996-08-20 | Biogen, Inc. | CD2-binding domain of lymphocyte function associated antigen 3 |
EP0503646A1 (de) * | 1991-03-12 | 1992-09-16 | Biogen, Inc. | Monoklonale Antikörper gegen Lymphozytenfunktionassoziertes Antigen-3 |
AU660312B2 (en) * | 1991-06-06 | 1995-06-22 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | LFA-3-like protein, derivatives thereof, genes thereof and processes for preparing the same |
ATE210454T1 (de) * | 1991-10-07 | 2001-12-15 | Biogen Inc | Verfahren zur verbesserung der toleranz für allotransplantaten und xenotransplantaten durch verabreichung eines lfa-3- oder cd2- bindungsproteins |
EP0607332B1 (de) * | 1991-10-07 | 1997-12-17 | Biogen, Inc. | Vorbeugungsmethode oder behandlung von, durch antigen-präsentierende zellen hervorgerufene, hautkrankheiten mittels inhibitoren der cd2/lfa-3 wechselwirkung |
DK0671933T3 (da) * | 1992-08-20 | 1998-09-23 | Schering Corp | Hidtil ukendte anvendelser af IL-10 |
SE9302738L (sv) * | 1993-08-25 | 1995-02-26 | Cito Trading Co | Anordning för kraftöverföring mellan räl för spårbundet fordon och fundament |
JPH10507906A (ja) * | 1994-08-19 | 1998-08-04 | ザ ジェネラル ホスピタル コーポレイション | 遺伝子工学処理したブタ細胞 |
EP0867449A4 (de) * | 1995-04-19 | 2000-08-09 | Kanegafuchi Chemical Ind | Zellädhasionsprotein, dier enthaltende immunsuppressive mittel, sowie immunsuppressiva, die zellen enthalten, welche damit induziert wurden |
US7663394B2 (en) * | 2006-01-25 | 2010-02-16 | Nec Corporation | Start signal detector circuit |
-
1998
- 1998-03-20 US US09/045,106 patent/US6001651A/en not_active Expired - Lifetime
-
1999
- 1999-03-17 AT AT99913927T patent/ATE317021T1/de not_active IP Right Cessation
- 1999-03-17 WO PCT/US1999/005837 patent/WO1999047707A1/en active IP Right Grant
- 1999-03-17 EP EP99913927A patent/EP1064402B1/de not_active Expired - Lifetime
- 1999-03-17 JP JP2000536889A patent/JP3590585B2/ja not_active Expired - Fee Related
- 1999-03-17 AU AU31891/99A patent/AU3189199A/en not_active Abandoned
- 1999-03-17 DE DE69929683T patent/DE69929683D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU3189199A (en) | 1999-10-11 |
US6001651A (en) | 1999-12-14 |
EP1064402A4 (de) | 2003-06-11 |
JP3590585B2 (ja) | 2004-11-17 |
EP1064402A1 (de) | 2001-01-03 |
EP1064402B1 (de) | 2006-02-01 |
WO1999047707A1 (en) | 1999-09-23 |
ATE317021T1 (de) | 2006-02-15 |
JP2002506658A (ja) | 2002-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |