ATE264913T1 - Protease-resistente analoge des thrombomodulin - Google Patents

Protease-resistente analoge des thrombomodulin

Info

Publication number
ATE264913T1
ATE264913T1 AT93905821T AT93905821T ATE264913T1 AT E264913 T1 ATE264913 T1 AT E264913T1 AT 93905821 T AT93905821 T AT 93905821T AT 93905821 T AT93905821 T AT 93905821T AT E264913 T1 ATE264913 T1 AT E264913T1
Authority
AT
Austria
Prior art keywords
thrombomodulin
protease
methods
resistant analogues
analogues
Prior art date
Application number
AT93905821T
Other languages
English (en)
Inventor
David Richard Light
William H Andrews
Jeffrey Homer Clarke
Robert Michael Wydro
Patricia Ann Young
Original Assignee
Paion Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Gmbh filed Critical Paion Gmbh
Application granted granted Critical
Publication of ATE264913T1 publication Critical patent/ATE264913T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT93905821T 1992-02-05 1993-02-05 Protease-resistente analoge des thrombomodulin ATE264913T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83057792A 1992-02-05 1992-02-05
PCT/US1993/001120 WO1993015755A1 (en) 1992-02-05 1993-02-05 Protease-resistant thrombomodulin analogs

Publications (1)

Publication Number Publication Date
ATE264913T1 true ATE264913T1 (de) 2004-05-15

Family

ID=25257242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905821T ATE264913T1 (de) 1992-02-05 1993-02-05 Protease-resistente analoge des thrombomodulin

Country Status (9)

Country Link
EP (2) EP1449849A3 (de)
JP (2) JP3517236B2 (de)
AT (1) ATE264913T1 (de)
AU (1) AU675422B2 (de)
CA (1) CA2129370A1 (de)
DE (1) DE69333491T2 (de)
ES (1) ES2220905T3 (de)
PT (1) PT641215E (de)
WO (1) WO1993015755A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013385A2 (en) * 1993-11-12 1995-05-18 Gilead Sciences Thrombin mutants
US7060484B1 (en) 1993-11-12 2006-06-13 Gilead Sciences, Inc. Polypeptides and coagulation therapy
DE69433133T2 (de) * 1993-12-17 2004-04-01 Mochida Pharmaceutical Co. Ltd. Lösliches thrombomodulin enthaltende zubereitung
EP1446151A1 (de) * 2001-11-09 2004-08-18 Novo Nordisk Health Care AG Pharmazeutische zusammensetzung mit faktor-vii- polypeptiden und thrombomodulin-polypeptiden
US20080255047A1 (en) * 2005-10-13 2008-10-16 Brian William Grinnell Method of Treating Acute Renal Failure with Thrombomobulin Variant
BRPI0720158A2 (pt) 2006-10-06 2014-05-20 Asahi Kasei Pharma Corp Agentes para terapia e/ou melhora de coagulação intravascular disseminada, para reduzir a probabilidade de morte em pacientes sofrendo da mesma, métodos para selecionar pacientes, e, para tratar e/ou melhorar coagulação intravascular disseminada
TW201431872A (zh) 2007-03-23 2014-08-16 Asahi Kasei Pharma Corp 高純度可溶性凝血酶調節素之製造方法
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
EP2014296A1 (de) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Neuartige Strategien zur Erhöhung der Reperfusion in einem verstopften Blutgefäß
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
EP2320936A1 (de) * 2008-07-16 2011-05-18 PAION Deutschland GmbH Prävention und behandlung von strahlenschäden
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
AU2009347614A1 (en) 2009-06-12 2012-01-19 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
CN103037893A (zh) 2010-06-14 2013-04-10 帕昂德国有限公司 具有纤溶亢进的凝血病的治疗
US9592275B2 (en) 2011-11-15 2017-03-14 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
JP2015522024A (ja) 2012-06-29 2015-08-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 糖タンパク質の凝集を低下させるための方法
CA3116686A1 (en) 2018-10-22 2020-04-30 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis accompanied by coagulopathy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
AU646633B2 (en) * 1989-02-17 1994-03-03 Codon Soluble analogs of thrombomodulin
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
JPH03259084A (ja) * 1990-03-06 1991-11-19 Kowa Co トロンビン結合性物質の製造法
WO1993001282A1 (en) * 1991-07-01 1993-01-21 Berlex Laboratories, Inc. Novel mutagenesis methods and compositions
AU4533093A (en) * 1992-06-10 1994-01-04 Michael John Morser Mutants of the epidermal growth factor domains of human thrombomodulin

Also Published As

Publication number Publication date
CA2129370A1 (en) 1993-08-19
WO1993015755A1 (en) 1993-08-19
JPH07503849A (ja) 1995-04-27
EP1449849A2 (de) 2004-08-25
ES2220905T3 (es) 2004-12-16
EP1449849A3 (de) 2006-01-25
EP0641215A1 (de) 1995-03-08
AU675422B2 (en) 1997-02-06
AU3659393A (en) 1993-09-03
EP0641215B1 (de) 2004-04-21
DE69333491T2 (de) 2005-03-31
DE69333491D1 (en) 2004-05-27
JP2004105188A (ja) 2004-04-08
EP0641215A4 (de) 1995-11-29
PT641215E (pt) 2004-09-30
JP3517236B2 (ja) 2004-04-12

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Legal Events

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