DK299087D0 - Proteins and derivatives thereof - Google Patents

Proteins and derivatives thereof

Info

Publication number
DK299087D0
DK299087D0 DK299087A DK299087A DK299087D0 DK 299087 D0 DK299087 D0 DK 299087D0 DK 299087 A DK299087 A DK 299087A DK 299087 A DK299087 A DK 299087A DK 299087 D0 DK299087 D0 DK 299087D0
Authority
DK
Denmark
Prior art keywords
proteins
derivatives
Prior art date
Application number
DK299087A
Other languages
English (en)
Inventor
Bjoern Andersen Nexoe
Esper Boel
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK299087A priority Critical patent/DK299087D0/da
Publication of DK299087D0 publication Critical patent/DK299087D0/da
Priority to JP63505229A priority patent/JPH03503757A/ja
Priority to EP88905725A priority patent/EP0365568A1/en
Priority to PCT/DK1988/000089 priority patent/WO1988009811A1/en
Priority to DK627389A priority patent/DK162169C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK299087A 1987-06-12 1987-06-12 Proteins and derivatives thereof DK299087D0 (da)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DK299087A DK299087D0 (da) 1987-06-12 1987-06-12 Proteins and derivatives thereof
JP63505229A JPH03503757A (ja) 1987-06-12 1988-06-09 タンパク質およびその誘導体
EP88905725A EP0365568A1 (en) 1987-06-12 1988-06-09 Proteins and derivatives thereof
PCT/DK1988/000089 WO1988009811A1 (en) 1987-06-12 1988-06-09 Proteins and derivatives thereof
DK627389A DK162169C (da) 1987-06-12 1989-12-12 Rekombinate proteiner med thrombomodulinaktivitet, dna konstruktioner kodende herfor, vektorer, celler samt fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende proteinerne, samt anvendelse af proteinerne til overtraekning

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK299087A DK299087D0 (da) 1987-06-12 1987-06-12 Proteins and derivatives thereof

Publications (1)

Publication Number Publication Date
DK299087D0 true DK299087D0 (da) 1987-06-12

Family

ID=8117912

Family Applications (1)

Application Number Title Priority Date Filing Date
DK299087A DK299087D0 (da) 1987-06-12 1987-06-12 Proteins and derivatives thereof

Country Status (4)

Country Link
EP (1) EP0365568A1 (da)
JP (1) JPH03503757A (da)
DK (1) DK299087D0 (da)
WO (1) WO1988009811A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2766473B2 (ja) * 1987-01-08 1998-06-18 旭化成工業株式会社 トロンビンによるプロテインｃの活性化を促進するペプチド
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
KR920701459A (ko) * 1989-02-17 1992-08-11 코돈 트롬보모듈린의 가용성 유사체
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US6239101B1 (en) 1989-07-05 2001-05-29 Oklahoma Medical Research Foundation Thrombin binding polypeptides
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
EP0489180A4 (en) * 1990-06-27 1993-03-31 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
KR930008093B1 (ko) * 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
DK0544826T3 (da) * 1990-08-15 2002-04-22 Paion Gmbh Overlegne trombomodulinanaloger til farmaceutisk anvendelse
JP3517236B2 (ja) * 1992-02-05 2004-04-12 シェーリング アクチェンゲゼルシャフト プロテアーゼ−耐性トロンボモジュリン・アナログ
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
DE69535317T2 (de) 1994-10-18 2007-06-21 Dendreon Corp., Seattle Aus nematoden extrahierte serinprotease-inhibitoren und die koagulation hemmende proteine
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
JPH11299487A (ja) * 1996-04-03 1999-11-02 Asahi Chem Ind Co Ltd 新規遺伝子
MXPA04010851A (es) 2002-05-01 2005-02-14 Schering Ag Proteinas de fusion de trombomodulina dirigidas al factor tisular novedoso como anticoagulantes.
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
AU2007305550B2 (en) 2006-10-06 2010-09-30 Asahi Kasei Pharma Corporation Agent for Therapy and/or Improvement of Disseminated Intravascular Coagulation
CN101641368B (zh) 2007-03-23 2013-05-08 旭化成制药株式会社 高纯度可溶性血栓调节蛋白的制造方法
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
EP3150628A1 (en) 2010-04-30 2017-04-05 Asahi Kasei Pharma Corporation Highly-purified soluble thrombomodulin
AU2011287360A1 (en) * 2010-08-05 2013-02-21 Council Of Scientific & Industrial Research Protein fusion constructs possessing thrombolytic and anticoagulant properties
WO2013073545A1 (ja) 2011-11-15 2013-05-23 旭化成ファーマ株式会社 敗血症の治療及び／又は改善のための医薬
CN104394885B (zh) 2012-05-31 2017-06-30 学校法人近畿大学 抗癌剂所致的末梢神经障碍性疼痛的预防和/或治疗剂
WO2020067389A1 (ja) 2018-09-28 2020-04-02 旭化成ファーマ株式会社 抗悪性腫瘍剤による末梢神経障害の症状軽減及び／又は発症抑制のための医薬
MX2021004511A (es) 2018-10-22 2021-06-08 Asahi Kasei Pharma Corp Medicamento para el tratamiento y/o mejora de la septicemia asociada con la anomalia de la coagulacion.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000050A1 (fr) * 1985-06-28 1987-01-15 Asahi Kasei Kogyo Kabushiki Kaisha Nouvelle substance physiologiquement active limitant la coagulation du sang

Also Published As

Publication number Publication date
EP0365568A1 (en) 1990-05-02
WO1988009811A1 (en) 1988-12-15
JPH03503757A (ja) 1991-08-22

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Legal Events

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AHS Application shelved for other reasons than non-payment