DK0544826T3 - Overlegne trombomodulinanaloger til farmaceutisk anvendelse - Google Patents

Overlegne trombomodulinanaloger til farmaceutisk anvendelse

Info

Publication number
DK0544826T3
DK0544826T3 DK91918117T DK91918117T DK0544826T3 DK 0544826 T3 DK0544826 T3 DK 0544826T3 DK 91918117 T DK91918117 T DK 91918117T DK 91918117 T DK91918117 T DK 91918117T DK 0544826 T3 DK0544826 T3 DK 0544826T3
Authority
DK
Denmark
Prior art keywords
thrombin
superior
pharmaceutical use
analogs
methods
Prior art date
Application number
DK91918117T
Other languages
English (en)
Inventor
Michael John Morser
Charles B Glaser
David Richard Light
Original Assignee
Paion Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Gmbh filed Critical Paion Gmbh
Application granted granted Critical
Publication of DK0544826T3 publication Critical patent/DK0544826T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK91918117T 1990-08-15 1991-08-15 Overlegne trombomodulinanaloger til farmaceutisk anvendelse DK0544826T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56845690A 1990-08-15 1990-08-15
PCT/US1991/005806 WO1992003149A1 (en) 1990-08-15 1991-08-15 Superior thrombomodulin analogs for pharmaceutical use

Publications (1)

Publication Number Publication Date
DK0544826T3 true DK0544826T3 (da) 2002-04-22

Family

ID=24271371

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91918117T DK0544826T3 (da) 1990-08-15 1991-08-15 Overlegne trombomodulinanaloger til farmaceutisk anvendelse

Country Status (8)

Country Link
EP (1) EP0544826B1 (da)
AT (1) ATE211390T1 (da)
AU (2) AU8723391A (da)
CA (2) CA2648350A1 (da)
DE (1) DE69132889T2 (da)
DK (1) DK0544826T3 (da)
ES (1) ES2170747T3 (da)
WO (1) WO1992003149A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
FR2689640B1 (fr) * 1992-04-06 1997-08-08 Bio Merieux Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
EP0965597A4 (en) 1996-12-27 2003-01-08 Mochida Pharm Co Ltd CELL MEMBRANE EFFECTIVE DRUGS
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
CA2502539A1 (en) * 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
CN101522206B (zh) 2006-10-06 2013-03-27 旭化成制药株式会社 弥散性血管内凝血综合征的治疗剂和/或改善剂
ES2496596T3 (es) 2007-03-23 2014-09-19 Asahi Kasei Pharma Corporation Método para producir trombomodulina soluble de gran pureza
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
US20120270789A1 (en) 2009-06-12 2012-10-25 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
CA2802072A1 (en) 2010-06-14 2011-12-22 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
PL2781221T3 (pl) 2011-11-15 2020-08-24 Asahi Kasei Pharma Corporation Lek do leczenia i/lub uzyskiwania poprawy w posocznicy
MX2021004511A (es) 2018-10-22 2021-06-08 Asahi Kasei Pharma Corp Medicamento para el tratamiento y/o mejora de la septicemia asociada con la anomalia de la coagulacion.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
CA2046906A1 (en) * 1989-02-17 1990-08-18 Michael J. Morser Soluble analogs of thrombomodulin
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs

Also Published As

Publication number Publication date
CA2087271A1 (en) 1992-02-16
DE69132889D1 (de) 2002-02-07
DE69132889T2 (de) 2002-08-29
AU8723391A (en) 1992-03-17
AU692988B2 (en) 1998-06-18
CA2648350A1 (en) 1992-03-05
ATE211390T1 (de) 2002-01-15
WO1992003149A1 (en) 1992-03-05
ES2170747T3 (es) 2002-08-16
AU4554396A (en) 1996-04-26
EP0544826A1 (en) 1993-06-09
EP0544826A4 (da) 1994-04-27
CA2087271C (en) 2009-03-24
EP0544826B1 (en) 2002-01-02

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Glaser et al. Superior thrombomodulin analogs for pharmaceutical use