DE69132889D1 - Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung - Google Patents

Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung

Info

Publication number
DE69132889D1
DE69132889D1 DE69132889T DE69132889T DE69132889D1 DE 69132889 D1 DE69132889 D1 DE 69132889D1 DE 69132889 T DE69132889 T DE 69132889T DE 69132889 T DE69132889 T DE 69132889T DE 69132889 D1 DE69132889 D1 DE 69132889D1
Authority
DE
Germany
Prior art keywords
thrombin
analogs
superior
pharmaceutical use
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132889T
Other languages
English (en)
Other versions
DE69132889T2 (de
Inventor
B Glaser
John Morser
Richard Light
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paion Deutschland GmbH
Original Assignee
Paion GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion GmbH filed Critical Paion GmbH
Application granted granted Critical
Publication of DE69132889D1 publication Critical patent/DE69132889D1/de
Publication of DE69132889T2 publication Critical patent/DE69132889T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69132889T 1990-08-15 1991-08-15 Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung Expired - Fee Related DE69132889T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56845690A 1990-08-15 1990-08-15
PCT/US1991/005806 WO1992003149A1 (en) 1990-08-15 1991-08-15 Superior thrombomodulin analogs for pharmaceutical use

Publications (2)

Publication Number Publication Date
DE69132889D1 true DE69132889D1 (de) 2002-02-07
DE69132889T2 DE69132889T2 (de) 2002-08-29

Family

ID=24271371

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132889T Expired - Fee Related DE69132889T2 (de) 1990-08-15 1991-08-15 Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung

Country Status (8)

Country Link
EP (1) EP0544826B1 (de)
AT (1) ATE211390T1 (de)
AU (2) AU8723391A (de)
CA (2) CA2087271C (de)
DE (1) DE69132889T2 (de)
DK (1) DK0544826T3 (de)
ES (1) ES2170747T3 (de)
WO (1) WO1992003149A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
FR2689640B1 (fr) * 1992-04-06 1997-08-08 Bio Merieux Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
CA2276091A1 (en) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Cell membrane-directed drugs
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
EP1551987A1 (de) * 2002-10-17 2005-07-13 Pharming Intellectual Property B.V. Protein-modifikatoin
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20100152106A1 (en) 2006-10-06 2010-06-17 Asahi Kasei Pharma Corporation Agent for therapy and/or improvement of disseminated intravascular coagulation
NZ579873A (en) 2007-03-23 2011-11-25 Asahi Kasei Pharma Corp Method for producing soluble thrombomodulin of high purity
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
JP2012529445A (ja) 2009-06-12 2012-11-22 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
SG10201500036WA (en) 2010-04-30 2015-02-27 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
BR112012031920A2 (pt) 2010-06-14 2017-05-16 Paion Deutschland Gmbh tratamento de coagulopatias com hiperfibrinólise.
KR101672108B1 (ko) 2011-11-15 2016-11-02 아사히 가세이 파마 가부시키가이샤 패혈증의 치료 및/또는 개선을 위한 의약
MX2021004511A (es) 2018-10-22 2021-06-08 Asahi Kasei Pharma Corp Medicamento para el tratamiento y/o mejora de la septicemia asociada con la anomalia de la coagulacion.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
KR920701459A (ko) * 1989-02-17 1992-08-11 코돈 트롬보모듈린의 가용성 유사체
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs

Also Published As

Publication number Publication date
DK0544826T3 (da) 2002-04-22
ES2170747T3 (es) 2002-08-16
CA2648350A1 (en) 1992-03-05
EP0544826A1 (de) 1993-06-09
CA2087271C (en) 2009-03-24
DE69132889T2 (de) 2002-08-29
CA2087271A1 (en) 1992-02-16
ATE211390T1 (de) 2002-01-15
AU4554396A (en) 1996-04-26
EP0544826B1 (de) 2002-01-02
EP0544826A4 (de) 1994-04-27
WO1992003149A1 (en) 1992-03-05
AU8723391A (en) 1992-03-17
AU692988B2 (en) 1998-06-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee