AU8723391A - Superior thrombomodulin analogs for pharmaceutical use - Google Patents

Superior thrombomodulin analogs for pharmaceutical use

Info

Publication number
AU8723391A
AU8723391A AU87233/91A AU8723391A AU8723391A AU 8723391 A AU8723391 A AU 8723391A AU 87233/91 A AU87233/91 A AU 87233/91A AU 8723391 A AU8723391 A AU 8723391A AU 8723391 A AU8723391 A AU 8723391A
Authority
AU
Australia
Prior art keywords
thrombomodulin
analog
thrombin
protein
native
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU87233/91A
Other languages
English (en)
Inventor
Charles B Glaser
David Richard Light
Michael John Morser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU8723391A publication Critical patent/AU8723391A/en
Assigned to SCHERING AKTIENGESELLSCHAFT reassignment SCHERING AKTIENGESELLSCHAFT Alteration of Name(s) of Applicant(s) under S113 Assignors: BERLEX LABORATORIES, INC.
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU87233/91A 1990-08-15 1991-08-15 Superior thrombomodulin analogs for pharmaceutical use Abandoned AU8723391A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56845690A 1990-08-15 1990-08-15
US568456 1990-08-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU45543/96A Division AU692988B2 (en) 1990-08-15 1996-02-14 Superior thrombomodulin analogs for pharmaceutical use

Publications (1)

Publication Number Publication Date
AU8723391A true AU8723391A (en) 1992-03-17

Family

ID=24271371

Family Applications (2)

Application Number Title Priority Date Filing Date
AU87233/91A Abandoned AU8723391A (en) 1990-08-15 1991-08-15 Superior thrombomodulin analogs for pharmaceutical use
AU45543/96A Ceased AU692988B2 (en) 1990-08-15 1996-02-14 Superior thrombomodulin analogs for pharmaceutical use

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU45543/96A Ceased AU692988B2 (en) 1990-08-15 1996-02-14 Superior thrombomodulin analogs for pharmaceutical use

Country Status (8)

Country Link
EP (1) EP0544826B1 (de)
AT (1) ATE211390T1 (de)
AU (2) AU8723391A (de)
CA (2) CA2087271C (de)
DE (1) DE69132889T2 (de)
DK (1) DK0544826T3 (de)
ES (1) ES2170747T3 (de)
WO (1) WO1992003149A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
FR2689640B1 (fr) * 1992-04-06 1997-08-08 Bio Merieux Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
US6500646B1 (en) 1996-12-27 2002-12-31 Mochida Pharmaceutical Co., Ltd. Cell membrane-directed drugs
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
CA2502539A1 (en) * 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
BRPI0720158A2 (pt) 2006-10-06 2014-05-20 Asahi Kasei Pharma Corp Agentes para terapia e/ou melhora de coagulação intravascular disseminada, para reduzir a probabilidade de morte em pacientes sofrendo da mesma, métodos para selecionar pacientes, e, para tratar e/ou melhorar coagulação intravascular disseminada
TW201431872A (zh) 2007-03-23 2014-08-16 Asahi Kasei Pharma Corp 高純度可溶性凝血酶調節素之製造方法
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
AU2009347614A1 (en) 2009-06-12 2012-01-19 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
CN103037893A (zh) 2010-06-14 2013-04-10 帕昂德国有限公司 具有纤溶亢进的凝血病的治疗
US9592275B2 (en) 2011-11-15 2017-03-14 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
CA3116686A1 (en) 2018-10-22 2020-04-30 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis accompanied by coagulopathy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
AU646633B2 (en) * 1989-02-17 1994-03-03 Codon Soluble analogs of thrombomodulin
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs

Also Published As

Publication number Publication date
DK0544826T3 (da) 2002-04-22
WO1992003149A1 (en) 1992-03-05
EP0544826B1 (de) 2002-01-02
ES2170747T3 (es) 2002-08-16
DE69132889T2 (de) 2002-08-29
AU692988B2 (en) 1998-06-18
CA2087271A1 (en) 1992-02-16
DE69132889D1 (de) 2002-02-07
CA2648350A1 (en) 1992-03-05
EP0544826A1 (de) 1993-06-09
ATE211390T1 (de) 2002-01-15
EP0544826A4 (de) 1994-04-27
CA2087271C (en) 2009-03-24
AU4554396A (en) 1996-04-26

Similar Documents

Publication Publication Date Title
US5256770A (en) Oxidation resistant thrombomodulin analogs
US6063763A (en) Protease-resistant thrombomodulin analogs
US5466668A (en) Superior thrombomodulin analogs for pharmaceutical use
AU675422B2 (en) Protease-resistant thrombomodulin analogs
EP0544826B1 (de) Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung
JP4855627B2 (ja) 医薬用途のためのトロンボモジュリン
AU646633B2 (en) Soluble analogs of thrombomodulin
WO1993025675A1 (en) Mutants of the epidermal growth factor domains of human thrombomodulin
WO1992006999A1 (en) Therapeutic fragments of von willebrand factor