ES2114555T3 - Nuevo interferon gamma humano recombinado. - Google Patents

Nuevo interferon gamma humano recombinado.

Info

Publication number
ES2114555T3
ES2114555T3 ES92900077T ES92900077T ES2114555T3 ES 2114555 T3 ES2114555 T3 ES 2114555T3 ES 92900077 T ES92900077 T ES 92900077T ES 92900077 T ES92900077 T ES 92900077T ES 2114555 T3 ES2114555 T3 ES 2114555T3
Authority
ES
Spain
Prior art keywords
new
gamma interferon
concerns
human gamma
recombined human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900077T
Other languages
English (en)
Inventor
Otto Slodowski
Joachim Bohm
Bernd Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Application granted granted Critical
Publication of ES2114555T3 publication Critical patent/ES2114555T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

LA INVENCION SE REFIERE A UN NUEVO MUTANTE DEL TIPO GAMMA IFN. ESTE NUEVO POLIPEPTIDO CONTIENEN 134 AMINOACIDOS. LOS AMINOACIDOS 1 HASTA 132 SON LOS MISMOS QUE AQUELLOS DEL INTERFERON GAMMA NATURAL. EL PRIMER AMINOACIDO, METIONINA, ESTA TAMBIEN PRESENTE EN LA POSICION 0, TAL COMO HA SIDO DEMOSTRADO POR MEDIO DE SECUENCIADO DE PROTEINA. EL AMINOACIDO EN POSICION 133 ES LEUCINA EN LUGAR DE GLUTAMINA. LA INVENCION SE REFIERE TAMBIEN A LA SECUENCIA DNA Y A LA PLASMIDA DNA (DSM 6238) QUE SE CODIFICA PARA ESTE NUEVO POLIPEPTIDO. LA INVENCION SE REFIERE ADEMAS A LA UTILIZACION DEL POLIPEPTIDO COMO MEDICAMENTO ASI COMO A SU USO COMO REACTIVO QUIMICO FINO PARA EXPERIMENTOS IN VITRO.
ES92900077T 1990-11-19 1991-11-14 Nuevo interferon gamma humano recombinado. Expired - Lifetime ES2114555T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4036856A DE4036856C1 (es) 1990-11-19 1990-11-19

Publications (1)

Publication Number Publication Date
ES2114555T3 true ES2114555T3 (es) 1998-06-01

Family

ID=6418557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900077T Expired - Lifetime ES2114555T3 (es) 1990-11-19 1991-11-14 Nuevo interferon gamma humano recombinado.

Country Status (9)

Country Link
EP (1) EP0652903B1 (es)
JP (1) JP3219274B2 (es)
AT (1) ATE163651T1 (es)
AU (1) AU9026691A (es)
CA (1) CA2096532C (es)
DE (2) DE4036856C1 (es)
DK (1) DK0652903T3 (es)
ES (1) ES2114555T3 (es)
WO (1) WO1992008737A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19535853C2 (de) * 1995-09-18 1999-04-01 Fraunhofer Ges Forschung Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19604583C2 (de) * 1996-02-08 1999-11-18 Fraunhofer Ges Forschung Verfahren zur Synthese von löslichen, rekombinanten Proteinen aus Bakterienzellen
CN1309423C (zh) 1999-11-12 2007-04-11 马克西根控股公司 干扰素γ偶联物
EP1231943A1 (en) 1999-11-12 2002-08-21 Maxygen Holdings Ltd Interferon gamma conjugates
MXPA03009082A (es) * 2001-04-06 2004-11-22 Maxygen Holdings Ltd Variantes polipeptidicas de interferon gamma.
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
WO2004005341A2 (en) 2002-07-03 2004-01-15 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
WO2020077257A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof
WO2020076977A2 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
TW202021986A (zh) 2018-10-11 2020-06-16 美商英伊布里克斯公司 5t4單域抗體及其治療性組合物
CN113166261A (zh) 2018-10-11 2021-07-23 印希比股份有限公司 B7h3单域抗体及其治疗性组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
IL75302A0 (en) * 1984-06-06 1985-09-29 Takeda Chemical Industries Ltd Novel polypeptide and production thereof
JPS6124599A (ja) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−ｒポリペプチド誘導体
GB8619725D0 (en) * 1986-08-13 1986-09-24 Hoffmann La Roche Homogenous interferon fragments
DE3730331A1 (de) * 1987-09-10 1989-03-30 Basf Ag Neue polypeptide, verfahren zur herstellung, die vektoren dafuer und arzneimittel daraus

Also Published As

Publication number Publication date
JP3219274B2 (ja) 2001-10-15
WO1992008737A1 (de) 1992-05-29
JPH06502992A (ja) 1994-04-07
EP0652903A1 (de) 1995-05-17
DE59108947D1 (de) 1998-04-09
AU9026691A (en) 1992-06-11
EP0652903B1 (de) 1998-03-04
CA2096532A1 (en) 1992-05-20
CA2096532C (en) 2002-12-31
DE4036856C1 (es) 1992-05-27
DK0652903T3 (da) 1998-03-30
ATE163651T1 (de) 1998-03-15

Similar Documents

Publication Publication Date Title
NO953033D0 (no) Stabile baktericid/permeabilitetsökende proteinprodukter og farmasöytiske preparater inneholdende disse
ES8707974A1 (es) Procedimiento para la obtencion de un peptido
DE68929043T2 (de) Für androgen-rezeptor-protein kodierende dna
ATE402957T1 (de) Analoge des menschlichen interferon-alpha mit niedriger toxizität
IL85020A0 (en) Pancreatic secretory trypsin inhibitor and variants thereof,process expression vector and recombinant host therefor and pharmaceutical compositions containing it
HU9200548D0 (en) Improved activity process of recombined proteins
ES2114555T3 (es) Nuevo interferon gamma humano recombinado.
AU669483B2 (en) Nucleotide sequences and resistance proteins cycloheximide
AUPN154295A0 (en) Nucleic acid molecule encoding a protein with avian gamma-interferon activity
EP0330700A4 (en) Human prourokinase-like polypeptide.
DK595187A (da) Minactivin og fremgangsmaade til fremstilling deraf

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 652903

Country of ref document: ES