ES2114555T3 - Nuevo interferon gamma humano recombinado. - Google Patents

Nuevo interferon gamma humano recombinado.

Info

Publication number
ES2114555T3
ES2114555T3 ES92900077T ES92900077T ES2114555T3 ES 2114555 T3 ES2114555 T3 ES 2114555T3 ES 92900077 T ES92900077 T ES 92900077T ES 92900077 T ES92900077 T ES 92900077T ES 2114555 T3 ES2114555 T3 ES 2114555T3
Authority
ES
Spain
Prior art keywords
new
refers
gamma interferon
human gamma
recombined human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900077T
Other languages
English (en)
Inventor
Otto Slodowski
Joachim Bohm
Bernd Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Application granted granted Critical
Publication of ES2114555T3 publication Critical patent/ES2114555T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO MUTANTE DEL TIPO GAMMA IFN. ESTE NUEVO POLIPEPTIDO CONTIENEN 134 AMINOACIDOS. LOS AMINOACIDOS 1 HASTA 132 SON LOS MISMOS QUE AQUELLOS DEL INTERFERON GAMMA NATURAL. EL PRIMER AMINOACIDO, METIONINA, ESTA TAMBIEN PRESENTE EN LA POSICION 0, TAL COMO HA SIDO DEMOSTRADO POR MEDIO DE SECUENCIADO DE PROTEINA. EL AMINOACIDO EN POSICION 133 ES LEUCINA EN LUGAR DE GLUTAMINA. LA INVENCION SE REFIERE TAMBIEN A LA SECUENCIA DNA Y A LA PLASMIDA DNA (DSM 6238) QUE SE CODIFICA PARA ESTE NUEVO POLIPEPTIDO. LA INVENCION SE REFIERE ADEMAS A LA UTILIZACION DEL POLIPEPTIDO COMO MEDICAMENTO ASI COMO A SU USO COMO REACTIVO QUIMICO FINO PARA EXPERIMENTOS IN VITRO.
ES92900077T 1990-11-19 1991-11-14 Nuevo interferon gamma humano recombinado. Expired - Lifetime ES2114555T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4036856A DE4036856C1 (es) 1990-11-19 1990-11-19

Publications (1)

Publication Number Publication Date
ES2114555T3 true ES2114555T3 (es) 1998-06-01

Family

ID=6418557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900077T Expired - Lifetime ES2114555T3 (es) 1990-11-19 1991-11-14 Nuevo interferon gamma humano recombinado.

Country Status (9)

Country Link
EP (1) EP0652903B1 (es)
JP (1) JP3219274B2 (es)
AT (1) ATE163651T1 (es)
AU (1) AU9026691A (es)
CA (1) CA2096532C (es)
DE (2) DE4036856C1 (es)
DK (1) DK0652903T3 (es)
ES (1) ES2114555T3 (es)
WO (1) WO1992008737A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19535853C2 (de) * 1995-09-18 1999-04-01 Fraunhofer Ges Forschung Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19604583C2 (de) * 1996-02-08 1999-11-18 Fraunhofer Ges Forschung Verfahren zur Synthese von löslichen, rekombinanten Proteinen aus Bakterienzellen
YU32402A (sh) 1999-11-12 2005-03-15 Maxygen Holdings Ltd. Konjugati gama interferona
IL149267A0 (en) 1999-11-12 2002-11-10 Maxygen Holdings Ltd Interferon gamma conjugates
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
WO2002081507A2 (en) * 2001-04-06 2002-10-17 Maxygen Holdings Ltd. Interferon gamma polypeptide variants
AU2003239774A1 (en) 2002-07-03 2004-01-23 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
WO2020076977A2 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
CA3115082A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. B7h3 single domain antibodies and therapeutic compositions thereof
EP3864049A1 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof
US20210340273A1 (en) 2018-10-11 2021-11-04 Inhlbrx, inc. 5t4 single domain antibodies and therapeutic compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
IL75302A0 (en) * 1984-06-06 1985-09-29 Takeda Chemical Industries Ltd Novel polypeptide and production thereof
JPS6124599A (ja) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−ｒポリペプチド誘導体
GB8619725D0 (en) * 1986-08-13 1986-09-24 Hoffmann La Roche Homogenous interferon fragments
DE3730331A1 (de) * 1987-09-10 1989-03-30 Basf Ag Neue polypeptide, verfahren zur herstellung, die vektoren dafuer und arzneimittel daraus

Also Published As

Publication number Publication date
EP0652903A1 (de) 1995-05-17
JP3219274B2 (ja) 2001-10-15
WO1992008737A1 (de) 1992-05-29
DE4036856C1 (es) 1992-05-27
EP0652903B1 (de) 1998-03-04
CA2096532C (en) 2002-12-31
JPH06502992A (ja) 1994-04-07
DK0652903T3 (da) 1998-03-30
ATE163651T1 (de) 1998-03-15
DE59108947D1 (de) 1998-04-09
CA2096532A1 (en) 1992-05-20
AU9026691A (en) 1992-06-11

Similar Documents

Publication Publication Date Title
ES2063515T3 (es) Ifn-alfa o-glucosilados.
ES2132066T3 (es) Procedimiento para la produccion de proteina biologicamente activa (v.g. tfg).
ES2114555T3 (es) Nuevo interferon gamma humano recombinado.
FI972654A7 (fi) Meletsitoosia laimentimena sisältävät jauhekoostumukset
ATE388165T1 (de) Menschliches cnp-gen und vorläuferprotein
ATE266043T1 (de) Peptidanaloge des menschlichen basischen myelinproteins
DE60224508D1 (de) Wti-modifiziertes peptid
MX9207334A (es) Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
SV1999000096A (es) Calcio (3s) de propilcarbamato tetrahidro 3-furanil (1s,2r)-3-[[(4-aminofenil) sulfonilo] (isobutilo) amino]-1-bencilo-2-+fosfonooxilo ref. pg3508/sv/0
NO952744D0 (no) Cytokinbegrensende midler
FI953658A0 (fi) Stabiileja bakterisidisia/läpäisevyyttä parantavia proteiinituotteita ja näitä sisältäviä farmaseuttisia koostumuksia
ES2071815T3 (es) Analogos de delecion de los peptidos conocidos como magaininas.
DE69525544D1 (de) Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
ATE95195T1 (de) Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel.
DK0551077T3 (da) Anvendelse af humant atrialt natriuretisk peptid til fremstilling af farmaceutiske præparater til behandling af akut lungeb
ES2066510T3 (es) Nuevos polipeptidos con afinidad para lipopolisacaridos y sus usos.
MX9203175A (es) Composicion de implante que contiene un peptido, polipeptido o proteina biologicamente activa y procedimiento para su preparacion.
ES2078925T3 (es) Proteinas de la estreptoquinasa, genes correspondientes, recombinantes plasmidicos correspondientes, transformantes correspondientes y procedimientos para su preparacion.
AR004497A1 (es) Un análogo hexapéptido cíclico de somatostatina, procedimiento para prepararlos y las composiciones farmacéuticas que los contienen y el uso de dicho hexapéptido para la preparación de una composición farmacéutica.
HUP9602024A2 (hu) Aminosavtartalmú, külsőlegesen használható, gyógyhatású készítmény
ATE371737T1 (de) Proteaseresistente flint-analoge
AR036591A1 (es) Uso de la hl en hiperestimulacion ovarica controlada
DK0510913T3 (da) Farmaceutiske sammensætninger indeholdende calcitonin
ATE92078T1 (de) Pharmakologisch aktive peptide.
SV2003000836A (es) Profarmaco del amino acido estimulantes ref. x-14649

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 652903

Country of ref document: ES