AU9026691A - New human recombinant gamma interferon - Google Patents
New human recombinant gamma interferonInfo
- Publication number
- AU9026691A AU9026691A AU90266/91A AU9026691A AU9026691A AU 9026691 A AU9026691 A AU 9026691A AU 90266/91 A AU90266/91 A AU 90266/91A AU 9026691 A AU9026691 A AU 9026691A AU 9026691 A AU9026691 A AU 9026691A
- Authority
- AU
- Australia
- Prior art keywords
- human recombinant
- gamma interferon
- concerns
- new human
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000008070 Interferon-gamma Human genes 0.000 title 1
- 108010074328 Interferon-gamma Proteins 0.000 title 1
- 229940044627 gamma-interferon Drugs 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012847 fine chemical Substances 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 238000000734 protein sequencing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
The invention concerns a new mutant of $g(g)-IFN. This new polypeptide contains 134 amino acids. Amino acids 1 to 132 are the same as those of natural $g(g)-interferon. The first amino acid, methionine, in the zero position is also present, as has been demonstrated by protein sequencing. The amino acid in position 133 is leucine instead of glutamine. The invention also concerns DNA sequences and plasmid DNA (DSM 6238) which codes for this new polypeptide. The invention further concerns the use of the polypeptide as a drug as well as its use as a fine-chemical reagent for $i(in vitro) experiments.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4036856A DE4036856C1 (en) | 1990-11-19 | 1990-11-19 | |
| DE4036856 | 1990-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU9026691A true AU9026691A (en) | 1992-06-11 |
Family
ID=6418557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU90266/91A Abandoned AU9026691A (en) | 1990-11-19 | 1991-11-14 | New human recombinant gamma interferon |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0652903B1 (en) |
| JP (1) | JP3219274B2 (en) |
| AT (1) | ATE163651T1 (en) |
| AU (1) | AU9026691A (en) |
| CA (1) | CA2096532C (en) |
| DE (2) | DE4036856C1 (en) |
| DK (1) | DK0652903T3 (en) |
| ES (1) | ES2114555T3 (en) |
| WO (1) | WO1992008737A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19535853C2 (en) * | 1995-09-18 | 1999-04-01 | Fraunhofer Ges Forschung | Variants of recombinant human interferon gamma, process for their preparation and their use |
| DE19604583C2 (en) * | 1996-02-08 | 1999-11-18 | Fraunhofer Ges Forschung | Process for the synthesis of soluble, recombinant proteins from bacterial cells |
| JP2003513681A (en) | 1999-11-12 | 2003-04-15 | マキシゲン・ホールディングス・リミテッド | Interferon gamma conjugate |
| CN1309423C (en) | 1999-11-12 | 2007-04-11 | 马克西根控股公司 | Interferon gamma conjugates |
| US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
| JP2005518183A (en) * | 2001-04-06 | 2005-06-23 | マキシゲン・ホールディングズ・リミテッド | Interferon gamma polypeptide variant |
| US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
| AU2003239774A1 (en) | 2002-07-03 | 2004-01-23 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
| CN113166263A (en) | 2018-10-11 | 2021-07-23 | 印希比股份有限公司 | DLL3 single domain antibodies and therapeutic compositions thereof |
| AU2019356573A1 (en) | 2018-10-11 | 2021-05-27 | Inhibrx, Inc. | PD-1 single domain antibodies and therapeutic compositions thereof |
| CA3114693A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | 5t4 single domain antibodies and therapeutic compositions thereof |
| EP3864044A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | B7h3 single domain antibodies and therapeutic compositions thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| IL75302A0 (en) * | 1984-06-06 | 1985-09-29 | Takeda Chemical Industries Ltd | Novel polypeptide and production thereof |
| JPS6124599A (en) * | 1984-07-11 | 1986-02-03 | Kyowa Hakko Kogyo Co Ltd | Novel human interferon-gamma polypeptide derivative |
| GB8619725D0 (en) * | 1986-08-13 | 1986-09-24 | Hoffmann La Roche | Homogenous interferon fragments |
| DE3730331A1 (en) * | 1987-09-10 | 1989-03-30 | Basf Ag | NEW POLYPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE VECTORS THEREFOR AND MEDICINAL PRODUCTS THEREOF |
-
1990
- 1990-11-19 DE DE4036856A patent/DE4036856C1/de not_active Expired - Lifetime
-
1991
- 1991-11-14 WO PCT/DE1991/000912 patent/WO1992008737A1/en active IP Right Grant
- 1991-11-14 DE DE59108947T patent/DE59108947D1/en not_active Expired - Lifetime
- 1991-11-14 EP EP92900077A patent/EP0652903B1/en not_active Expired - Lifetime
- 1991-11-14 ES ES92900077T patent/ES2114555T3/en not_active Expired - Lifetime
- 1991-11-14 CA CA002096532A patent/CA2096532C/en not_active Expired - Lifetime
- 1991-11-14 JP JP50025492A patent/JP3219274B2/en not_active Expired - Fee Related
- 1991-11-14 DK DK92900077.6T patent/DK0652903T3/en active
- 1991-11-14 AT AT92900077T patent/ATE163651T1/en not_active IP Right Cessation
- 1991-11-14 AU AU90266/91A patent/AU9026691A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2096532C (en) | 2002-12-31 |
| CA2096532A1 (en) | 1992-05-20 |
| DK0652903T3 (en) | 1998-03-30 |
| DE59108947D1 (en) | 1998-04-09 |
| DE4036856C1 (en) | 1992-05-27 |
| JP3219274B2 (en) | 2001-10-15 |
| EP0652903B1 (en) | 1998-03-04 |
| WO1992008737A1 (en) | 1992-05-29 |
| ATE163651T1 (en) | 1998-03-15 |
| ES2114555T3 (en) | 1998-06-01 |
| JPH06502992A (en) | 1994-04-07 |
| EP0652903A1 (en) | 1995-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU561343B2 (en) | Human immune interferon by recombinant dna | |
| EP1013760A3 (en) | Stable bactericidal/permeabilityincreasing protein products and pharmaceutical compositions containing the same | |
| EP0307592A3 (en) | Analogues of the pancreatic bovine trypsin inhibitor, their production and use | |
| HU902697D0 (en) | Process for the enzymatic removal of the n-terminal sequence of proteins | |
| ES8707974A1 (en) | Oligopeptides, intermediates and process for their preparation. | |
| IL85020A0 (en) | Pancreatic secretory trypsin inhibitor and variants thereof,process expression vector and recombinant host therefor and pharmaceutical compositions containing it | |
| AU595221B2 (en) | Fusion proteins, a process for their preparation and their use | |
| AU9026691A (en) | New human recombinant gamma interferon | |
| IL81018A (en) | Fusion proteins comprising small fragments of human interleukin-2 as ballast,process for its preparation and genes,vectors and transformed host containing said fragments and used in the process | |
| AU669483B2 (en) | Nucleotide sequences and resistance proteins cycloheximide | |
| EP0210279A4 (en) | Stabilized human prourokinase. | |
| HUT50195A (en) | New peptites hindering the activity of immune system and medical compositions containing them and process for production of these peptides and compositions | |
| AUPN154295A0 (en) | Nucleic acid molecule encoding a protein with avian gamma-interferon activity | |
| EP0330700A4 (en) | Human prourokinase-like polypeptide. | |
| AU585167B2 (en) | Novel substrate peptides | |
| EP0238275A3 (en) | Recombinant product | |
| JPS6437299A (en) | Novel physiologically active polypeptide |