DK0652903T3 - New human recombinant gamma interferon - Google Patents
New human recombinant gamma interferonInfo
- Publication number
- DK0652903T3 DK0652903T3 DK92900077.6T DK92900077T DK0652903T3 DK 0652903 T3 DK0652903 T3 DK 0652903T3 DK 92900077 T DK92900077 T DK 92900077T DK 0652903 T3 DK0652903 T3 DK 0652903T3
- Authority
- DK
- Denmark
- Prior art keywords
- human recombinant
- gamma interferon
- concerns
- new human
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
The invention concerns a new mutant of $g(g)-IFN. This new polypeptide contains 134 amino acids. Amino acids 1 to 132 are the same as those of natural $g(g)-interferon. The first amino acid, methionine, in the zero position is also present, as has been demonstrated by protein sequencing. The amino acid in position 133 is leucine instead of glutamine. The invention also concerns DNA sequences and plasmid DNA (DSM 6238) which codes for this new polypeptide. The invention further concerns the use of the polypeptide as a drug as well as its use as a fine-chemical reagent for $i(in vitro) experiments.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4036856A DE4036856C1 (en) | 1990-11-19 | 1990-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0652903T3 true DK0652903T3 (en) | 1998-03-30 |
Family
ID=6418557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92900077.6T DK0652903T3 (en) | 1990-11-19 | 1991-11-14 | New human recombinant gamma interferon |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0652903B1 (en) |
JP (1) | JP3219274B2 (en) |
AT (1) | ATE163651T1 (en) |
AU (1) | AU9026691A (en) |
CA (1) | CA2096532C (en) |
DE (2) | DE4036856C1 (en) |
DK (1) | DK0652903T3 (en) |
ES (1) | ES2114555T3 (en) |
WO (1) | WO1992008737A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19535853C2 (en) * | 1995-09-18 | 1999-04-01 | Fraunhofer Ges Forschung | Variants of recombinant human interferon gamma, process for their preparation and their use |
DE19604583C2 (en) * | 1996-02-08 | 1999-11-18 | Fraunhofer Ges Forschung | Process for the synthesis of soluble, recombinant proteins from bacterial cells |
SK8292002A3 (en) | 1999-11-12 | 2002-12-03 | Maxygen Holdings Ltd | A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof |
CN1309423C (en) | 1999-11-12 | 2007-04-11 | 马克西根控股公司 | Interferon gamma conjugates |
US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
JP2005518183A (en) * | 2001-04-06 | 2005-06-23 | マキシゲン・ホールディングズ・リミテッド | Interferon gamma polypeptide variant |
US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
WO2004005341A2 (en) | 2002-07-03 | 2004-01-15 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
CA3115082A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | B7h3 single domain antibodies and therapeutic compositions thereof |
CN113518647A (en) | 2018-10-11 | 2021-10-19 | 印希比股份有限公司 | 5T4 single domain antibodies and therapeutic compositions thereof |
US20210380679A1 (en) | 2018-10-11 | 2021-12-09 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
EP3864049A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
IL75302A0 (en) * | 1984-06-06 | 1985-09-29 | Takeda Chemical Industries Ltd | Novel polypeptide and production thereof |
JPS6124599A (en) * | 1984-07-11 | 1986-02-03 | Kyowa Hakko Kogyo Co Ltd | Novel human interferon-gamma polypeptide derivative |
GB8619725D0 (en) * | 1986-08-13 | 1986-09-24 | Hoffmann La Roche | Homogenous interferon fragments |
DE3730331A1 (en) * | 1987-09-10 | 1989-03-30 | Basf Ag | NEW POLYPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE VECTORS THEREFOR AND MEDICINAL PRODUCTS THEREOF |
-
1990
- 1990-11-19 DE DE4036856A patent/DE4036856C1/de not_active Expired - Lifetime
-
1991
- 1991-11-14 AU AU90266/91A patent/AU9026691A/en not_active Abandoned
- 1991-11-14 JP JP50025492A patent/JP3219274B2/en not_active Expired - Fee Related
- 1991-11-14 WO PCT/DE1991/000912 patent/WO1992008737A1/en active IP Right Grant
- 1991-11-14 ES ES92900077T patent/ES2114555T3/en not_active Expired - Lifetime
- 1991-11-14 EP EP92900077A patent/EP0652903B1/en not_active Expired - Lifetime
- 1991-11-14 AT AT92900077T patent/ATE163651T1/en not_active IP Right Cessation
- 1991-11-14 DE DE59108947T patent/DE59108947D1/en not_active Expired - Lifetime
- 1991-11-14 CA CA002096532A patent/CA2096532C/en not_active Expired - Lifetime
- 1991-11-14 DK DK92900077.6T patent/DK0652903T3/en active
Also Published As
Publication number | Publication date |
---|---|
ES2114555T3 (en) | 1998-06-01 |
EP0652903A1 (en) | 1995-05-17 |
CA2096532C (en) | 2002-12-31 |
AU9026691A (en) | 1992-06-11 |
DE4036856C1 (en) | 1992-05-27 |
JPH06502992A (en) | 1994-04-07 |
DE59108947D1 (en) | 1998-04-09 |
WO1992008737A1 (en) | 1992-05-29 |
ATE163651T1 (en) | 1998-03-15 |
CA2096532A1 (en) | 1992-05-20 |
EP0652903B1 (en) | 1998-03-04 |
JP3219274B2 (en) | 2001-10-15 |
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