HRP20220918T1 - Anti-transtiretinska antitijela - Google Patents
Anti-transtiretinska antitijela Download PDFInfo
- Publication number
- HRP20220918T1 HRP20220918T1 HRP20220918TT HRP20220918T HRP20220918T1 HR P20220918 T1 HRP20220918 T1 HR P20220918T1 HR P20220918T T HRP20220918T T HR P20220918TT HR P20220918 T HRP20220918 T HR P20220918T HR P20220918 T1 HRP20220918 T1 HR P20220918T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- heavy chain
- antibody according
- constant region
- light chain
- Prior art date
Links
- 108010071690 Prealbumin Proteins 0.000 claims 4
- 102000009190 Transthyretin Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 206010002022 amyloidosis Diseases 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000003259 recombinant expression Methods 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 210000003403 autonomic nervous system Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Claims (15)
1. Antitijelo koje se specifično veže na transtiretin koje sadrži varijabilnu regiju zrelog teškog lanca SEQ ID NO:5 i varijabilnu regiju zrelog lakog lanca SEQ ID NO:13.
2. Antitijelo prema zahtjevu 1, naznačeno time, da ima ljudski IgG1 izotip.
3. Antitijelo prema zahtjevu 1, naznačeno time, da ima ljudski IgG2 ili IgG4 izotip.
4. Antitijelo prema zahtjevu 1 koje je vezni fragment; izborno gdje je vezni fragment jednolančano protutijelo, Fab ili F(ab')2 fragment.
5. Antitijelo prema zahtjevu 1, naznačeno time da je varijabilna regija zrelog lakog lanca spojena s konstantnom regijom lakog lanca, a varijabilna regija zrelog teškog lanca spojena je s konstantnom regijom teškog lanca.
6. Protutijelo prema zahtjevu 5, naznačeno time da je konstantna regija teškog lanca mutantni oblik prirodne konstantne regije ljudskog teškog lanca koja ima smanjeno vezanje na Fcγ receptor u odnosu na prirodnu konstantnu regiju teškog lanca čovjeka.
7. Antitijelo prema zahtjevu 5, naznačeno time da je konstantna regija teškog lanca IgG1 izotipa.
8. Protutijelo prema zahtjevu 5, naznačeno time da je varijabilna regija zrelog teškog lanca spojena na konstantnu regiju teškog lanca koja ima sekvencu SEQ ID NO: 23 sa ili bez C-terminalnog lizina i/ili je varijabilna regija zrelog lakog lanca spojen na konstantnu regiju lakog lanca koja ima sekvencu SEQ ID NO:25.
9. Farmaceutski pripravak, naznačen time, da sadrži protutijelo prema bilo kojem od prethodnih zahtjeva i farmaceutski prihvatljiv nosač.
10. Nukleinska kiselina koja kodira teški i laki lanac protutijela, ili nukleinske kiseline koje kodiraju teški i laki lanac protutijela, pri čemu je protutijelo kako je opisano u bilo kojem od zahtjeva 1-8.
11. Rekombinantni ekspresijski vektor koji sadrži nukleinsku kiselinu prema zahtjevu 10 ili rekombinantni ekspresijski vektor koji sadrži nukleinske kiseline prema zahtjevu 10.
12. Stanica domaćin transformirana s rekombinantnim ekspresijskim vektorom(ima) prema zahtjevu 11.
13. Protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-8 za upotrebu u liječenju ili djelovanju profilakse transtiretinom posredovane amiloidoze, ili odgode početka transtiretinom posredovane amiloidoze kod subjekta, pri čemu upotreba uključuje davanje subjektu učinkovitog režima antitijela.
14. In vitro metoda dijagnosticiranja amiloidoze posredovane transtiretinom kod subjekta, naznačena time, da se sastoji od dovođenja u kontakt biološkog uzorka subjekta s učinkovitom količinom protutijela prema bilo kojem od zahtjeva 1-8.
15. In vitro metoda prema zahtjevu 14, naznačena time što je biološki uzorak krv, serum, plazma ili čvrsto tkivo; izborno iz srca, perifernog živčanog sustava, autonomnog živčanog sustava, bubrega, očiju ili gastrointestinalnog trakta.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109004P | 2015-01-28 | 2015-01-28 | |
| US201562266555P | 2015-12-11 | 2015-12-11 | |
| PCT/IB2016/050416 WO2016120811A1 (en) | 2015-01-28 | 2016-01-28 | Anti-transthyretin antibodies |
| EP16702990.9A EP3250593B1 (en) | 2015-01-28 | 2016-01-28 | Anti-transthyretin antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220918T1 true HRP20220918T1 (hr) | 2022-10-28 |
Family
ID=55300737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220918TT HRP20220918T1 (hr) | 2015-01-28 | 2016-01-28 | Anti-transtiretinska antitijela |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20160257737A1 (hr) |
| EP (1) | EP3250593B1 (hr) |
| JP (1) | JP7101927B2 (hr) |
| KR (1) | KR102649788B1 (hr) |
| CN (1) | CN107406500B (hr) |
| AU (1) | AU2016210889C1 (hr) |
| BR (1) | BR112017016345A2 (hr) |
| CA (1) | CA2974993A1 (hr) |
| CO (1) | CO2017008482A2 (hr) |
| CU (1) | CU20170098A7 (hr) |
| DK (1) | DK3250593T3 (hr) |
| EA (1) | EA036014B1 (hr) |
| ES (1) | ES2925716T3 (hr) |
| HR (1) | HRP20220918T1 (hr) |
| HU (1) | HUE059592T2 (hr) |
| MX (1) | MX2017009803A (hr) |
| MY (1) | MY193701A (hr) |
| PE (1) | PE20180218A1 (hr) |
| PL (1) | PL3250593T3 (hr) |
| PT (1) | PT3250593T (hr) |
| RS (1) | RS63513B1 (hr) |
| SA (1) | SA517381981B1 (hr) |
| SG (2) | SG11201706126WA (hr) |
| SI (1) | SI3250593T1 (hr) |
| TW (2) | TWI769570B (hr) |
| WO (1) | WO2016120811A1 (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| EP3478716A2 (en) * | 2016-07-02 | 2019-05-08 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| SG11202002489YA (en) * | 2017-10-06 | 2020-04-29 | Prothena Biosciences Ltd | Anti-transthyretin antibodies |
| JOP20200132A1 (ar) | 2017-11-29 | 2022-10-30 | Prothena Biosciences Ltd [Ie/Ie] | صيغة مجففة بالتبريد من جسم مضاد أحادي النسيلة ضد ترانس ثيرتين |
| US20210230257A1 (en) * | 2018-06-26 | 2021-07-29 | Mor Research Applications | Transthyretin antibodies and uses thereof |
| CN111018976B (zh) * | 2018-10-10 | 2022-04-01 | 东莞市朋志生物科技有限公司 | 一种抗人心肌肌钙蛋白i的重组抗体 |
| CA3118618A1 (en) * | 2018-11-09 | 2020-05-14 | Neurimmune Ag | Patient-derived amyloid xenograft non-human animal model |
| CN114127125A (zh) * | 2019-07-08 | 2022-03-01 | 安进公司 | 多特异性甲状腺素转运蛋白免疫球蛋白融合物 |
| CN116804186B (zh) * | 2023-07-05 | 2023-12-22 | 中国兽医药品监察所 | 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用 |
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2016
- 2016-01-27 TW TW109138086A patent/TWI769570B/zh active
- 2016-01-27 TW TW105102532A patent/TWI711631B/zh active
- 2016-01-28 ES ES16702990T patent/ES2925716T3/es active Active
- 2016-01-28 CA CA2974993A patent/CA2974993A1/en active Pending
- 2016-01-28 SG SG11201706126WA patent/SG11201706126WA/en unknown
- 2016-01-28 HR HRP20220918TT patent/HRP20220918T1/hr unknown
- 2016-01-28 WO PCT/IB2016/050416 patent/WO2016120811A1/en active Application Filing
- 2016-01-28 RS RS20220788A patent/RS63513B1/sr unknown
- 2016-01-28 PE PE2017001289A patent/PE20180218A1/es unknown
- 2016-01-28 SG SG10201906696RA patent/SG10201906696RA/en unknown
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