DK3250593T3 - Anti-transthyretin-antistoffer - Google Patents

Anti-transthyretin-antistoffer Download PDF

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Publication number
DK3250593T3
DK3250593T3 DK16702990.9T DK16702990T DK3250593T3 DK 3250593 T3 DK3250593 T3 DK 3250593T3 DK 16702990 T DK16702990 T DK 16702990T DK 3250593 T3 DK3250593 T3 DK 3250593T3
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Denmark
Prior art keywords
transthyretin antibodies
transthyretin
antibodies
Prior art date
Application number
DK16702990.9T
Other languages
English (en)
Inventor
Avijit Chakrabartty
Tarlochan S Nijjar
Jeffrey N Higaki
Original Assignee
Prothena Biosciences Ltd
Univ Health Network
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Filing date
Publication date
Application filed by Prothena Biosciences Ltd, Univ Health Network filed Critical Prothena Biosciences Ltd
Application granted granted Critical
Publication of DK3250593T3 publication Critical patent/DK3250593T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16702990.9T 2015-01-28 2016-01-28 Anti-transthyretin-antistoffer DK3250593T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109004P 2015-01-28 2015-01-28
US201562266555P 2015-12-11 2015-12-11
PCT/IB2016/050416 WO2016120811A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Publications (1)

Publication Number Publication Date
DK3250593T3 true DK3250593T3 (da) 2022-08-22

Family

ID=55300737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16702990.9T DK3250593T3 (da) 2015-01-28 2016-01-28 Anti-transthyretin-antistoffer

Country Status (25)

Country Link
US (1) US20160257737A1 (da)
EP (1) EP3250593B1 (da)
JP (1) JP7101927B2 (da)
KR (1) KR102649788B1 (da)
CN (1) CN107406500B (da)
AU (1) AU2016210889C1 (da)
CA (1) CA2974993A1 (da)
CO (1) CO2017008482A2 (da)
CU (1) CU20170098A7 (da)
DK (1) DK3250593T3 (da)
EA (1) EA036014B1 (da)
ES (1) ES2925716T3 (da)
HR (1) HRP20220918T1 (da)
HU (1) HUE059592T2 (da)
MX (1) MX389911B (da)
MY (1) MY193701A (da)
PE (1) PE20180218A1 (da)
PL (1) PL3250593T3 (da)
PT (1) PT3250593T (da)
RS (1) RS63513B1 (da)
SA (1) SA517381981B1 (da)
SG (2) SG11201706126WA (da)
SI (1) SI3250593T1 (da)
TW (2) TWI769570B (da)
WO (1) WO2016120811A1 (da)

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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
EP3478716A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
CA3076630A1 (en) 2017-10-04 2019-04-11 Amgen Inc. Transthyretin immunoglobulin fusions
MX2020003041A (es) * 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
WO2019071206A1 (en) 2017-10-06 2019-04-11 Prothena Biosciences Limited METHODS OF DETECTING TRANSTHYRETIN
MX2020005433A (es) 2017-11-29 2020-08-27 Prothena Biosciences Ltd Formulacion liofilizada de un anticuerpo monoclonal contra la transtirretina.
ES3057459T3 (en) 2018-06-26 2026-03-02 Mor Research Applic Ltd Transthyretin antibodies and uses thereof
CN111018976B (zh) * 2018-10-10 2022-04-01 东莞市朋志生物科技有限公司 一种抗人心肌肌钙蛋白i的重组抗体
US20210400932A1 (en) * 2018-11-09 2021-12-30 Neurimmune Ag Patient-derived amyloid xenograft non-human animal model
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WO2021007150A1 (en) * 2019-07-08 2021-01-14 Amgen Inc. Multispecific transthyretin immunoglobulin fusions
JP7753264B2 (ja) 2020-06-24 2025-10-14 プロシーナ バイオサイエンシーズ リミテッド ソルチリンを認識する抗体
CN118059229A (zh) * 2020-10-14 2024-05-24 维里迪安治疗公司 用于治疗甲状腺眼病的组合物和方法
TWI891945B (zh) * 2020-12-03 2025-08-01 大陸商江蘇恒瑞醫藥股份有限公司 抗tslp抗體藥物組合物及其用途
US20240052050A1 (en) * 2020-12-16 2024-02-15 Merus N.V. Multispecific antibodies for the treatment of cancer
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CN116804186B (zh) * 2023-07-05 2023-12-22 中国兽医药品监察所 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用
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Also Published As

Publication number Publication date
PL3250593T3 (pl) 2022-09-19
SG10201906696RA (en) 2019-08-27
EP3250593B1 (en) 2022-06-22
SA517381981B1 (ar) 2022-05-17
SG11201706126WA (en) 2017-08-30
EA036014B1 (ru) 2020-09-14
HUE059592T2 (hu) 2022-11-28
CN107406500A (zh) 2017-11-28
MY193701A (en) 2022-10-25
SI3250593T1 (sl) 2022-09-30
MX2017009803A (es) 2018-08-15
TWI711631B (zh) 2020-12-01
CA2974993A1 (en) 2016-08-04
AU2016210889C1 (en) 2022-02-10
CU20170098A7 (es) 2018-03-13
TW201636371A (zh) 2016-10-16
RS63513B1 (sr) 2022-09-30
MX389911B (es) 2025-03-04
EP3250593A1 (en) 2017-12-06
WO2016120811A1 (en) 2016-08-04
HRP20220918T1 (hr) 2022-10-28
CO2017008482A2 (es) 2018-01-16
BR112017016345A2 (pt) 2018-03-27
CN107406500B (zh) 2022-02-25
AU2016210889A1 (en) 2017-08-10
KR102649788B1 (ko) 2024-03-20
JP2018510617A (ja) 2018-04-19
ES2925716T3 (es) 2022-10-19
TWI769570B (zh) 2022-07-01
US20160257737A1 (en) 2016-09-08
TW202110896A (zh) 2021-03-16
JP7101927B2 (ja) 2022-07-19
PE20180218A1 (es) 2018-01-31
PT3250593T (pt) 2022-08-31
AU2016210889B2 (en) 2021-10-21
KR20170120608A (ko) 2017-10-31
EA201791710A1 (ru) 2017-12-29

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