PL3215530T3 - Ulepszone przeciwciała anty-il-6 - Google Patents
Ulepszone przeciwciała anty-il-6Info
- Publication number
- PL3215530T3 PL3215530T3 PL15797538T PL15797538T PL3215530T3 PL 3215530 T3 PL3215530 T3 PL 3215530T3 PL 15797538 T PL15797538 T PL 15797538T PL 15797538 T PL15797538 T PL 15797538T PL 3215530 T3 PL3215530 T3 PL 3215530T3
- Authority
- PL
- Poland
- Prior art keywords
- antibodies
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077105P | 2014-11-07 | 2014-11-07 | |
| US201462087448P | 2014-12-04 | 2014-12-04 | |
| US201562247705P | 2015-10-28 | 2015-10-28 | |
| EP15797538.4A EP3215530B9 (en) | 2014-11-07 | 2015-11-06 | Improved il-6 antibodies |
| PCT/US2015/059532 WO2016073890A1 (en) | 2014-11-07 | 2015-11-06 | Improved il-6 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3215530T3 true PL3215530T3 (pl) | 2020-05-18 |
Family
ID=54602042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15797538T PL3215530T3 (pl) | 2014-11-07 | 2015-11-06 | Ulepszone przeciwciała anty-il-6 |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US11142571B2 (pl) |
| EP (3) | EP4268843A3 (pl) |
| JP (1) | JP6594438B2 (pl) |
| KR (2) | KR102636726B1 (pl) |
| CN (1) | CN107249631B (pl) |
| AU (1) | AU2015342882B2 (pl) |
| BR (1) | BR112017008672A2 (pl) |
| CA (1) | CA2965689C (pl) |
| CL (1) | CL2017001135A1 (pl) |
| CO (1) | CO2017005404A2 (pl) |
| CR (1) | CR20170231A (pl) |
| DK (1) | DK3215530T3 (pl) |
| EA (1) | EA035199B1 (pl) |
| ES (1) | ES2756275T3 (pl) |
| HK (1) | HK1244008A1 (pl) |
| HR (1) | HRP20191945T1 (pl) |
| HU (1) | HUE046181T2 (pl) |
| IL (1) | IL251858B (pl) |
| MA (1) | MA51554A (pl) |
| MX (2) | MX2017005992A (pl) |
| MY (1) | MY185114A (pl) |
| NZ (1) | NZ731090A (pl) |
| PE (1) | PE20171107A1 (pl) |
| PH (1) | PH12017500809A1 (pl) |
| PL (1) | PL3215530T3 (pl) |
| PT (1) | PT3215530T (pl) |
| RS (1) | RS59805B1 (pl) |
| SA (1) | SA517381458B1 (pl) |
| SG (2) | SG11201703574VA (pl) |
| SI (1) | SI3215530T1 (pl) |
| UA (1) | UA122673C2 (pl) |
| WO (1) | WO2016073890A1 (pl) |
| ZA (1) | ZA201702985B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL257565B1 (en) | 2015-09-23 | 2024-04-01 | Genentech Inc | Improved variants of anti-VEGF antibodies |
| US20190046642A1 (en) * | 2016-02-23 | 2019-02-14 | Eleven Biotherapeutics, Inc. | Il-6 antagonist formulations and uses thereof |
| EA201991207A1 (ru) * | 2016-12-19 | 2019-12-30 | Гленмарк Фармасьютикалс С.А. | Новые агонисты tnfr и их применение |
| CA3055985A1 (en) | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| MX2019011141A (es) | 2017-03-22 | 2019-11-05 | Genentech Inc | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares. |
| CN109867723B (zh) * | 2017-12-05 | 2022-06-17 | 南京金斯瑞生物科技有限公司 | 抗人il6单克隆抗体及其制备方法和用途 |
| CR20220461A (es) | 2020-03-13 | 2022-10-21 | Genentech Inc | Anticuerpos anti-interleucina-33 y usos de estos |
| CR20220489A (es) | 2020-03-24 | 2022-10-31 | Genentech Inc | Agentes de fijación a tie2 y métodos de uso. |
| EP4228702A1 (en) | 2020-10-15 | 2023-08-23 | F. Hoffmann-La Roche AG | Non-covalent protein-hyaluronan conjugates for long-acting ocular delivery |
| CN116355825A (zh) * | 2022-02-25 | 2023-06-30 | 南京工业大学 | 一种强化纤维素合成来提高人表皮生长因子分泌生产效率的方法 |
| WO2024088921A1 (en) * | 2022-10-24 | 2024-05-02 | F. Hoffmann-La Roche Ag | Predicting response to il-6 antagonists |
Family Cites Families (78)
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| US5476996A (en) | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
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| AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
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| WO2002088171A2 (en) | 2001-04-26 | 2002-11-07 | Avidia Research Institute | Combinatorial libraries of monomer domains |
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| BR0309844A (pt) | 2002-05-07 | 2005-02-15 | Control Delivery Sys Inc | Processos para formação de um dispositivo para a distribuição de droga |
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| JP5913307B2 (ja) | 2010-07-12 | 2016-04-27 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 多機能性抗体複合体 |
| KR101774121B1 (ko) | 2012-07-13 | 2017-09-01 | 로슈 글리카트 아게 | 이중특이적 항-vegf/항-ang-2 항체 및 안 혈관 질환의 치료에 있어서 이의 용도 |
| EP2911693A4 (en) | 2012-10-25 | 2016-04-27 | Medimmune Llc | STABLE, LOW-VISIC ANTIBODY FORMULATION |
| SG10201608703SA (en) * | 2012-11-08 | 2016-12-29 | Eleven Biotherapeutics Inc | Il-6 antagonists and uses thereof |
| KR20160030396A (ko) | 2013-07-12 | 2016-03-17 | 옵쏘테크 코포레이션 | 안과적 질환을 치료하거나 예방하기 위한 방법 |
| WO2016073894A1 (en) | 2014-11-07 | 2016-05-12 | Eleven Biotherapeutics, Inc. | Therapeutic agents with increased ocular retention |
-
2015
- 2015-11-06 WO PCT/US2015/059532 patent/WO2016073890A1/en active Application Filing
- 2015-11-06 AU AU2015342882A patent/AU2015342882B2/en active Active
- 2015-11-06 ES ES15797538T patent/ES2756275T3/es active Active
- 2015-11-06 HU HUE15797538A patent/HUE046181T2/hu unknown
- 2015-11-06 KR KR1020177014412A patent/KR102636726B1/ko active IP Right Grant
- 2015-11-06 EP EP23189385.0A patent/EP4268843A3/en active Pending
- 2015-11-06 EP EP15797538.4A patent/EP3215530B9/en active Active
- 2015-11-06 MY MYPI2017000609A patent/MY185114A/en unknown
- 2015-11-06 PE PE2017000804A patent/PE20171107A1/es unknown
- 2015-11-06 US US15/524,727 patent/US11142571B2/en active Active
- 2015-11-06 MX MX2017005992A patent/MX2017005992A/es unknown
- 2015-11-06 PT PT157975384T patent/PT3215530T/pt unknown
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