MA51554A - Anticorps il-6 améliorés - Google Patents

Anticorps il-6 améliorés

Info

Publication number
MA51554A
MA51554A MA051554A MA51554A MA51554A MA 51554 A MA51554 A MA 51554A MA 051554 A MA051554 A MA 051554A MA 51554 A MA51554 A MA 51554A MA 51554 A MA51554 A MA 51554A
Authority
MA
Morocco
Prior art keywords
antibodies
improved
Prior art date
Application number
MA051554A
Other languages
English (en)
Inventor
Eric Steven Furfine
Michael March Schmidt
Alison Tisdale
Grigorios Zarbis-Papastoitsis
Original Assignee
Sesen Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sesen Bio Inc filed Critical Sesen Bio Inc
Publication of MA51554A publication Critical patent/MA51554A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA051554A 2014-11-07 2015-11-06 Anticorps il-6 améliorés MA51554A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US201562247705P 2015-10-28 2015-10-28

Publications (1)

Publication Number Publication Date
MA51554A true MA51554A (fr) 2020-11-18

Family

ID=54602042

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051554A MA51554A (fr) 2014-11-07 2015-11-06 Anticorps il-6 améliorés

Country Status (33)

Country Link
US (2) US11142571B2 (fr)
EP (3) EP3632931A1 (fr)
JP (1) JP6594438B2 (fr)
KR (2) KR102636726B1 (fr)
CN (1) CN107249631B (fr)
AU (1) AU2015342882B2 (fr)
BR (1) BR112017008672A2 (fr)
CA (1) CA2965689C (fr)
CL (1) CL2017001135A1 (fr)
CO (1) CO2017005404A2 (fr)
CR (1) CR20170231A (fr)
DK (1) DK3215530T3 (fr)
EA (1) EA035199B1 (fr)
ES (1) ES2756275T3 (fr)
HK (1) HK1244008A1 (fr)
HR (1) HRP20191945T1 (fr)
HU (1) HUE046181T2 (fr)
IL (1) IL251858B (fr)
MA (1) MA51554A (fr)
MX (2) MX2017005992A (fr)
MY (1) MY185114A (fr)
NZ (1) NZ731090A (fr)
PE (1) PE20171107A1 (fr)
PH (1) PH12017500809A1 (fr)
PL (1) PL3215530T3 (fr)
PT (1) PT3215530T (fr)
RS (1) RS59805B1 (fr)
SA (1) SA517381458B1 (fr)
SG (2) SG10202103420PA (fr)
SI (1) SI3215530T1 (fr)
UA (1) UA122673C2 (fr)
WO (1) WO2016073890A1 (fr)
ZA (1) ZA201702985B (fr)

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MA42924A (fr) 2015-09-23 2018-08-01 Hoffmann La Roche Variants optimisés d'anticorps anti-vegf
JP2019510078A (ja) * 2016-02-23 2019-04-11 セセン バイオ, インコーポレイテッド Il−6アンタゴニスト製剤およびその使用
MX2019007144A (es) * 2016-12-19 2019-10-07 Glenmark Pharmaceuticals Sa Nuevos agonistas de tnfr y sus usos.
SG11201908650PA (en) 2017-03-22 2019-10-30 Genentech Inc Optimized antibody compositions for treatment of ocular disorders
SG10202107829YA (en) 2017-03-22 2021-08-30 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
JP2023517345A (ja) 2020-03-13 2023-04-25 ジェネンテック, インコーポレイテッド 抗インターロイキン-33抗体及びその使用
WO2021194913A1 (fr) 2020-03-24 2021-09-30 Genentech, Inc. Agents de liaison à tie2 et leurs procédés d'utilisation
AU2021361108A1 (en) 2020-10-15 2023-05-25 F. Hoffmann-La Roche Ag Non-covalent protein-hyaluronan conjugates for long-acting ocular delivery
CN114525235B (zh) * 2022-02-25 2023-07-14 郑州大学 一种提高人表皮生长因子分泌生产效率的方法
WO2024088921A1 (fr) * 2022-10-24 2024-05-02 F. Hoffmann-La Roche Ag Prédiction de réponse à des antagonistes d'il-6

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Also Published As

Publication number Publication date
KR20240023450A (ko) 2024-02-21
CA2965689A1 (fr) 2016-05-12
SG10202103420PA (en) 2021-05-28
MX2021008663A (es) 2021-08-19
EA201791005A1 (ru) 2017-09-29
ES2756275T9 (es) 2020-10-29
NZ731090A (en) 2024-03-22
HUE046181T2 (hu) 2020-02-28
CN107249631B (zh) 2021-11-23
JP2017535285A (ja) 2017-11-30
KR20170077196A (ko) 2017-07-05
IL251858A0 (en) 2017-06-29
EP4268843A2 (fr) 2023-11-01
JP6594438B2 (ja) 2019-10-23
PT3215530T (pt) 2019-11-21
EA035199B1 (ru) 2020-05-14
PE20171107A1 (es) 2017-08-07
US20190194312A1 (en) 2019-06-27
AU2015342882B2 (en) 2021-05-20
US11142571B2 (en) 2021-10-12
ZA201702985B (en) 2019-10-30
EP4268843A3 (fr) 2023-12-27
HRP20191945T1 (hr) 2020-01-24
SI3215530T1 (sl) 2020-02-28
WO2016073890A1 (fr) 2016-05-12
US20220169719A1 (en) 2022-06-02
PH12017500809A1 (en) 2017-10-02
CL2017001135A1 (es) 2017-12-15
EP3215530B9 (fr) 2020-09-09
EP3215530A1 (fr) 2017-09-13
BR112017008672A2 (pt) 2018-03-20
CR20170231A (es) 2017-09-25
DK3215530T3 (da) 2019-11-25
CA2965689C (fr) 2022-03-22
HK1244008A1 (zh) 2018-07-27
ES2756275T3 (es) 2020-04-27
PL3215530T3 (pl) 2020-05-18
AU2015342882A1 (en) 2017-05-18
RS59805B1 (sr) 2020-02-28
IL251858B (en) 2022-09-01
UA122673C2 (uk) 2020-12-28
CN107249631A (zh) 2017-10-13
KR102636726B1 (ko) 2024-02-13
MX2017005992A (es) 2017-09-15
SA517381458B1 (ar) 2020-07-09
SG11201703574VA (en) 2017-05-30
EP3215530B1 (fr) 2019-08-21
MY185114A (en) 2021-04-30
CO2017005404A2 (es) 2017-10-31
EP3632931A1 (fr) 2020-04-08

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