HK1244008A1 - 改進的il-6抗體 - Google Patents

改進的il-6抗體

Info

Publication number
HK1244008A1
HK1244008A1 HK18103370.4A HK18103370A HK1244008A1 HK 1244008 A1 HK1244008 A1 HK 1244008A1 HK 18103370 A HK18103370 A HK 18103370A HK 1244008 A1 HK1244008 A1 HK 1244008A1
Authority
HK
Hong Kong
Prior art keywords
antibodies
improved
Prior art date
Application number
HK18103370.4A
Other languages
English (en)
Inventor
Michael March Schmidt
Alison Tisdale
Eric Steven Furfine
Grigorios Zarbis-Papastoitsis
Original Assignee
Sesen Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sesen Bio Inc filed Critical Sesen Bio Inc
Publication of HK1244008A1 publication Critical patent/HK1244008A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
HK18103370.4A 2014-11-07 2018-03-10 改進的il-6抗體 HK1244008A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US201562247705P 2015-10-28 2015-10-28
PCT/US2015/059532 WO2016073890A1 (en) 2014-11-07 2015-11-06 Improved il-6 antibodies

Publications (1)

Publication Number Publication Date
HK1244008A1 true HK1244008A1 (zh) 2018-07-27

Family

ID=54602042

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103370.4A HK1244008A1 (zh) 2014-11-07 2018-03-10 改進的il-6抗體

Country Status (33)

Country Link
US (2) US11142571B2 (zh)
EP (3) EP3632931A1 (zh)
JP (1) JP6594438B2 (zh)
KR (2) KR102636726B1 (zh)
CN (1) CN107249631B (zh)
AU (1) AU2015342882B2 (zh)
BR (1) BR112017008672A2 (zh)
CA (1) CA2965689C (zh)
CL (1) CL2017001135A1 (zh)
CO (1) CO2017005404A2 (zh)
CR (1) CR20170231A (zh)
DK (1) DK3215530T3 (zh)
EA (1) EA035199B1 (zh)
ES (1) ES2756275T3 (zh)
HK (1) HK1244008A1 (zh)
HR (1) HRP20191945T1 (zh)
HU (1) HUE046181T2 (zh)
IL (1) IL251858B (zh)
MA (1) MA51554A (zh)
MX (2) MX2017005992A (zh)
MY (1) MY185114A (zh)
NZ (1) NZ731090A (zh)
PE (1) PE20171107A1 (zh)
PH (1) PH12017500809A1 (zh)
PL (1) PL3215530T3 (zh)
PT (1) PT3215530T (zh)
RS (1) RS59805B1 (zh)
SA (1) SA517381458B1 (zh)
SG (2) SG11201703574VA (zh)
SI (1) SI3215530T1 (zh)
UA (1) UA122673C2 (zh)
WO (1) WO2016073890A1 (zh)
ZA (1) ZA201702985B (zh)

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JP6959912B2 (ja) 2015-09-23 2021-11-05 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
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KR20190095941A (ko) * 2016-12-19 2019-08-16 그렌마크 파머수티칼스 에스. 아. 신규 tnfr 효능제 및 이의 용도
KR20200007776A (ko) 2017-03-22 2020-01-22 제넨테크, 인크. 히드로겔 가교된 히알루론산 전구약물 조성물 및 방법
BR112019019706A2 (pt) 2017-03-22 2020-04-28 Genentech Inc conjugado de anticorpo, anticorpo, composição farmacêutica, métodos para reduzir ou inibir angiogênese e para tratar um distúrbio ocular
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
EP4118114A1 (en) 2020-03-13 2023-01-18 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
PE20230414A1 (es) 2020-03-24 2023-03-07 Genentech Inc Agentes de fijacion a tie2 y metodos de uso
KR20230088743A (ko) 2020-10-15 2023-06-20 제넨테크, 인크. 치료제의 지속성 전달을 위한 베르시칸(vg1)의 히알루론산 결합 유도체
CN116355825A (zh) * 2022-02-25 2023-06-30 南京工业大学 一种强化纤维素合成来提高人表皮生长因子分泌生产效率的方法

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Also Published As

Publication number Publication date
AU2015342882A1 (en) 2017-05-18
IL251858B (en) 2022-09-01
SG10202103420PA (en) 2021-05-28
EP3215530B1 (en) 2019-08-21
CN107249631A (zh) 2017-10-13
DK3215530T3 (da) 2019-11-25
SI3215530T1 (sl) 2020-02-28
EP3215530A1 (en) 2017-09-13
JP2017535285A (ja) 2017-11-30
ZA201702985B (en) 2019-10-30
CL2017001135A1 (es) 2017-12-15
EA035199B1 (ru) 2020-05-14
CR20170231A (es) 2017-09-25
AU2015342882B2 (en) 2021-05-20
CA2965689C (en) 2022-03-22
UA122673C2 (uk) 2020-12-28
PH12017500809A1 (en) 2017-10-02
BR112017008672A2 (pt) 2018-03-20
SA517381458B1 (ar) 2020-07-09
JP6594438B2 (ja) 2019-10-23
ES2756275T9 (es) 2020-10-29
KR20240023450A (ko) 2024-02-21
MA51554A (fr) 2020-11-18
PE20171107A1 (es) 2017-08-07
US20190194312A1 (en) 2019-06-27
SG11201703574VA (en) 2017-05-30
PT3215530T (pt) 2019-11-21
CO2017005404A2 (es) 2017-10-31
MX2017005992A (es) 2017-09-15
EP3215530B9 (en) 2020-09-09
WO2016073890A1 (en) 2016-05-12
RS59805B1 (sr) 2020-02-28
CN107249631B (zh) 2021-11-23
EA201791005A1 (ru) 2017-09-29
EP4268843A2 (en) 2023-11-01
MY185114A (en) 2021-04-30
KR20170077196A (ko) 2017-07-05
EP4268843A3 (en) 2023-12-27
HRP20191945T1 (hr) 2020-01-24
MX2021008663A (es) 2021-08-19
CA2965689A1 (en) 2016-05-12
IL251858A0 (en) 2017-06-29
HUE046181T2 (hu) 2020-02-28
US20220169719A1 (en) 2022-06-02
NZ731090A (en) 2024-03-22
US11142571B2 (en) 2021-10-12
ES2756275T3 (es) 2020-04-27
KR102636726B1 (ko) 2024-02-13
PL3215530T3 (pl) 2020-05-18
EP3632931A1 (en) 2020-04-08

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