MX2009012492A - Anticuerpos para il-6 y sus usos. - Google Patents

Anticuerpos para il-6 y sus usos.

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Publication number
MX2009012492A
MX2009012492A MX2009012492A MX2009012492A MX2009012492A MX 2009012492 A MX2009012492 A MX 2009012492A MX 2009012492 A MX2009012492 A MX 2009012492A MX 2009012492 A MX2009012492 A MX 2009012492A MX 2009012492 A MX2009012492 A MX 2009012492A
Authority
MX
Mexico
Prior art keywords
antibodies
binding fragments
association
fragments
binding
Prior art date
Application number
MX2009012492A
Other languages
English (en)
Inventor
John Latham
Brian Kovacevich
Leon Garcia-Martinez
Katie Olson
Anne Elisabeth Carvalho Jensen
Ben Dutzar
Ethan Ojala
Jeffrey T L Smith
Original Assignee
Alder Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alder Biopharmaceuticals Inc filed Critical Alder Biopharmaceuticals Inc
Publication of MX2009012492A publication Critical patent/MX2009012492A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Abstract

La presente invención se dirige a anticuerpos y fragmentos de los mismos que tienen especificidad de enlace para IL-6. Otra modalidad de esta invención se relaciona a los anticuerpos descritos en la presente, y fragmentos de enlace de los mismos, que comprenden las secuencias de los polipéptidos VH, VL y CDR descritos en la presente, y los polinucleótidos que los codifican. La invención también contempla conjugados de anticuerpos anti-IL-6 y fragmentos de enlace de los mismos conjugados con una o más porciones funcionales o detectables. La invención también contempla métodos para hacer los anticuerpos anti-IL-6 y fragmentos de enlace de los mismos. Las modalidades de la invención también pertenecen al uso de anticuerpos anti-IL-6, y fragmentos de enlace de los mismos, para la diagnosis, estimación y tratamiento de enfermedades y desórdenes asociados con IL-6. Estos anticuerpos pueden enlazar por lo menos uno de IL-6 soluble, IL-6 expresado en la superficie celular, IL-6/IL-6R y/o prevenir la asociación de IL-6 e IL-6R, la asociación de IL-6/IL-6R y gp130 y/o la formación de multimeros IL-6/IL- 6R/gp130 y de esta manera inhibir un efecto biológico asociado con cualquiera de lo anterior.
MX2009012492A 2007-05-21 2008-05-21 Anticuerpos para il-6 y sus usos. MX2009012492A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92455007P 2007-05-21 2007-05-21
PCT/US2008/064432 WO2008144763A2 (en) 2007-05-21 2008-05-21 Antibodies to il-6 and use thereof

Publications (1)

Publication Number Publication Date
MX2009012492A true MX2009012492A (es) 2010-01-20

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009012492A MX2009012492A (es) 2007-05-21 2008-05-21 Anticuerpos para il-6 y sus usos.
MX2015001768A MX349322B (es) 2007-05-21 2008-05-21 Anticuerpos para il-6 y sus usos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015001768A MX349322B (es) 2007-05-21 2008-05-21 Anticuerpos para il-6 y sus usos.

Country Status (29)

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US (4) US20100290993A1 (es)
EP (2) EP3187506B1 (es)
JP (4) JP5833823B2 (es)
KR (3) KR101615715B1 (es)
CN (2) CN105001332B (es)
AU (1) AU2008254584B2 (es)
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