AU2014200210B2 - Antibodies to IL-6 and use thereof - Google Patents

Antibodies to IL-6 and use thereof

Info

Publication number
AU2014200210B2
AU2014200210B2 AU2014200210A AU2014200210A AU2014200210B2 AU 2014200210 B2 AU2014200210 B2 AU 2014200210B2 AU 2014200210 A AU2014200210 A AU 2014200210A AU 2014200210 A AU2014200210 A AU 2014200210A AU 2014200210 B2 AU2014200210 B2 AU 2014200210B2
Authority
AU
Australia
Prior art keywords
antibodies
binding fragments
association
fragments
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014200210A
Other versions
AU2014200210A1 (en
Inventor
Ben Dutzar
Leon Garcia-Martinez
Anne Elisabeth Carvalho Jensen
Brian Kovacevich
John Latham
Ethan Ojala
Katie Olson
Jeffrey T. I. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vitaeris Inc
Original Assignee
Vitaeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2008254584A external-priority patent/AU2008254584B2/en
Application filed by Vitaeris Inc filed Critical Vitaeris Inc
Priority to AU2014200210A priority Critical patent/AU2014200210B2/en
Publication of AU2014200210A1 publication Critical patent/AU2014200210A1/en
Assigned to ALDERBIO HOLDINGS LLC reassignment ALDERBIO HOLDINGS LLC Request for Assignment Assignors: ALDERBIO HOLDINGS LLC, BRISTOL-MYERS SQUIBB COMPANY
Application granted granted Critical
Publication of AU2014200210B2 publication Critical patent/AU2014200210B2/en
Assigned to H. LUNDBECK A/S reassignment H. LUNDBECK A/S Request for Assignment Assignors: ALDERBIO HOLDINGS LLC
Assigned to VITAERIS INC. reassignment VITAERIS INC. Request for Assignment Assignors: H. LUNDBECK A/S
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL 6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gpl3O multimers and thereby inhibit a biological effect associated with any of the foregoing.
AU2014200210A 2007-05-21 2014-01-14 Antibodies to IL-6 and use thereof Active AU2014200210B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014200210A AU2014200210B2 (en) 2007-05-21 2014-01-14 Antibodies to IL-6 and use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60/924,550 2007-05-21
AU2008254584A AU2008254584B2 (en) 2007-05-21 2008-05-21 Antibodies to IL-6 and use thereof
AU2014200210A AU2014200210B2 (en) 2007-05-21 2014-01-14 Antibodies to IL-6 and use thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2008254584A Division AU2008254584B2 (en) 2007-05-21 2008-05-21 Antibodies to IL-6 and use thereof

Publications (2)

Publication Number Publication Date
AU2014200210A1 AU2014200210A1 (en) 2014-01-30
AU2014200210B2 true AU2014200210B2 (en) 2016-07-14

Family

ID=50001425

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014200210A Active AU2014200210B2 (en) 2007-05-21 2014-01-14 Antibodies to IL-6 and use thereof

Country Status (1)

Country Link
AU (1) AU2014200210B2 (en)

Also Published As

Publication number Publication date
AU2014200210A1 (en) 2014-01-30

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Legal Events

Date Code Title Description
NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO MAKE A FURTHER APPLICATION FOR A DIVISIONAL PATENT HAS BEEN EXTENDED TO 03 FEB 2014 .

PC1 Assignment before grant (sect. 113)

Owner name: ALDERBIO HOLDINGS LLC

Free format text: FORMER APPLICANT(S): BRISTOL-MYERS SQUIBB COMPANY; ALDERBIO HOLDINGS LLC

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: H. LUNDBECK A/S

Free format text: FORMER OWNER(S): ALDERBIO HOLDINGS LLC

PC Assignment registered

Owner name: VITAERIS INC.

Free format text: FORMER OWNER(S): H. LUNDBECK A/S