ES2721753T3 - Anticuerpos contra IL-6 y usos de los mismos - Google Patents

Anticuerpos contra IL-6 y usos de los mismos Download PDF

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ES2721753T3
ES2721753T3 ES16195797T ES16195797T ES2721753T3 ES 2721753 T3 ES2721753 T3 ES 2721753T3 ES 16195797 T ES16195797 T ES 16195797T ES 16195797 T ES16195797 T ES 16195797T ES 2721753 T3 ES2721753 T3 ES 2721753T3
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seq
polypeptide consisting
amino acid
acid sequence
sequence
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Leon Garcia-Martinez
Anne Elisabeth Carvalho Jensen
Kate Olson
Ben Dutzar
Ethan Ojala
John Latham
Brian Kovacevich
Jeffrey T I Smith
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Alderbio Holdings LLC
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Alderbio Holdings LLC
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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Abstract

Un anticuerpo anti-IL6 que comprende: (a) una cadena ligera que comprende (i) un dominio variable ligero (VL) que comprende un polipéptido CDR1 que consiste en la secuencia de aminoácidos de SEQ ID NO: 4, un polipéptido CDR2 que consiste en la secuencia de aminoácidos de SEQ ID NO: 5, y un polipéptido CDR3 que consiste en la secuencia de aminoácidos de SEQ ID NO: 6, y (ii) un dominio constante ligero (CL) que comprende un polipéptido que consiste en la secuencia de aminoácidos de SEQ ID NO: 586; y (b) una cadena pesada que comprende (i) un dominio variable pesado (VH) que comprende un polipéptido de CDR1 que consiste en la secuencia de aminoácidos de la SEQ ID NO: 7, un polipéptido de CDR2 que consiste en la secuencia de aminoácidos de la SEQ UD NO:8 o la SEQ ID NO: 120, y un polipéptido de CDR3 que consiste en la secuencia de aminoácidos de la SEQ ID NO: 9, y (ii) un dominio constante pesado (CH) que comprende un polipéptido que consiste en la secuencia de aminoácidos de la SEQ ID NO: 588, en donde el anticuerpo tiene una constante de disociación (KD) de menos de 50 picomolar tal como se evalúa mediante Biacore.
ES16195797T 2007-05-21 2008-05-21 Anticuerpos contra IL-6 y usos de los mismos Active ES2721753T3 (es)

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US (4) US20100290993A1 (es)
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