ATE214602T1 - Verstärker eines anti-tumoragens beinhaltend einen il-6 antagonisten - Google Patents

Verstärker eines anti-tumoragens beinhaltend einen il-6 antagonisten

Info

Publication number
ATE214602T1
ATE214602T1 AT95942318T AT95942318T ATE214602T1 AT E214602 T1 ATE214602 T1 AT E214602T1 AT 95942318 T AT95942318 T AT 95942318T AT 95942318 T AT95942318 T AT 95942318T AT E214602 T1 ATE214602 T1 AT E214602T1
Authority
AT
Austria
Prior art keywords
antagonist
tumor agent
amplifier including
antibody against
potentiator
Prior art date
Application number
AT95942318T
Other languages
English (en)
Inventor
Osamu Yoshida
Youichi Mizutani
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18336838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE214602(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE214602T1 publication Critical patent/ATE214602T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT95942318T 1994-12-29 1995-12-28 Verstärker eines anti-tumoragens beinhaltend einen il-6 antagonisten ATE214602T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34042594 1994-12-29
PCT/JP1995/002769 WO1996020728A1 (fr) 1994-12-29 1995-12-28 Potentialisateur d'agent antitumoral comprenant un antagoniste de l'interleukine 6

Publications (1)

Publication Number Publication Date
ATE214602T1 true ATE214602T1 (de) 2002-04-15

Family

ID=18336838

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95942318T ATE214602T1 (de) 1994-12-29 1995-12-28 Verstärker eines anti-tumoragens beinhaltend einen il-6 antagonisten

Country Status (12)

Country Link
US (1) US6086874A (de)
EP (1) EP0800829B2 (de)
JP (2) JP4079461B2 (de)
KR (1) KR100252743B1 (de)
CN (1) CN1075387C (de)
AT (1) ATE214602T1 (de)
AU (1) AU704723B2 (de)
CA (1) CA2209124C (de)
DE (1) DE69525971T3 (de)
ES (1) ES2170815T5 (de)
HK (1) HK1001512A1 (de)
WO (1) WO1996020728A1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503939A (en) * 1983-08-19 1985-03-12 Westinghouse Electric Corp. Elevator system
CA2284271C (en) 1997-03-21 2012-05-08 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient
IT1291932B1 (it) * 1997-06-20 1999-01-21 Angeletti P Ist Richerche Bio Composizioni farmaceutiche antitumorali capaci anche di ridurre la farmacoresistenza in cellule tumorali, in particolare di carcinoma
US20020187150A1 (en) * 1997-08-15 2002-12-12 Chugai Seiyaku Kabushiki Kaisha Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
DE19818044A1 (de) * 1998-04-22 1999-10-28 Klinge Co Chem Pharm Fab Verwendung von Vitamin-PP-Verbindungen
US6468528B1 (en) * 1999-02-01 2002-10-22 Amgen Canada Inc. Materials and methods to inhibit Hodgkin and Reed Sternberg cell growth
UA80091C2 (en) * 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
US7053050B2 (en) 2001-11-02 2006-05-30 Yoshiko Yasuda Preventives/remedies for proliferative organ diseases chronic arthritic diseases, hypertrophic scar or keloid
IL161630A0 (en) * 2001-11-06 2004-09-27 Applied Research Systems Methods of treating endometreosis
PT2308888T (pt) 2001-11-14 2017-05-03 Janssen Biotech Inc Anticorpos anti-il-6, composições, métodos e utilizações
ES2546797T3 (es) * 2002-01-18 2015-09-28 Zymogenetics, Inc. Multímeros Zcytor17 receptores de citocinas
EP1475101B1 (de) * 2002-02-14 2010-10-27 Chugai Seiyaku Kabushiki Kaisha Antikörper enthaltende pharmazeutische lösungen
US20050255103A1 (en) * 2002-04-25 2005-11-17 Chugai Seiyaku Kabushiki Kaisha Remedy for lung cancer
CA2506230A1 (en) * 2002-11-15 2004-06-03 Centocor, Inc. Anti-angiogenic uses of il-6 antagonists
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
US8398980B2 (en) * 2004-03-24 2013-03-19 Chugai Seiyaku Kabushiki Kaisha Subtypes of humanized antibody against interleuken-6 receptor
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
CN102321174B (zh) 2005-05-06 2013-10-16 津莫吉尼蒂克斯公司 Il-31单克隆抗体及使用方法
SI1888123T1 (sl) 2005-06-08 2013-04-30 Janssen Biotech, Inc. Celična terapija za okularno degeneracijo
JP2007091710A (ja) * 2005-08-31 2007-04-12 Ishikawajima Harima Heavy Ind Co Ltd 薬、薬の誘導装置、磁気検出装置及び薬の設計方法
ATE550353T1 (de) * 2005-12-30 2012-04-15 Merck Patent Gmbh Die bindung von mit il-6ralpha komplexiertem il-6 an gp130 verhindernde anti-il-6-antikörper
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US8080248B2 (en) 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
ATE537190T1 (de) 2006-06-02 2011-12-15 Regeneron Pharma Hochaffine antikörper gegen den humanen il-6- rezeptor
CN103705947A (zh) 2006-06-28 2014-04-09 株式会社Ihi 药物、药物引导装置、磁性检测装置和药物设计方法
US7919095B2 (en) 2006-08-03 2011-04-05 Vaccinex, Inc. Anti-IL-6 monoclonal antibodies
US20080081041A1 (en) * 2006-09-29 2008-04-03 Jeffrey Nemeth Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
KR101829776B1 (ko) * 2007-05-21 2018-02-19 앨더바이오 홀딩스 엘엘씨 Ｉｌ-６에 대한 항체 및 이의 용도
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
NZ581418A (en) * 2007-05-21 2012-08-31 Alderbio Holdings Llc Novel rabbit antibody humanization methods and humanized rabbit antibodies
US8178101B2 (en) * 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8062864B2 (en) * 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
MX2010001335A (es) 2007-07-31 2010-06-02 Lifescan Inc Diferenciacion de celulas madre embrionarias humanas.
CN101246160B (zh) * 2007-09-06 2012-11-21 三峡大学 在体外用ELISA方法建立的IL-6/sIL-6R结合的分子模型
RU2490025C2 (ru) * 2007-10-02 2013-08-20 Чугаи Сейяку Кабусики Кайся Терапевтические средства, используемые против реакции трансплантат против хозяина, содержащие в качестве активного ингредиента ингибитор рецептора интерлейкина-6
KR101592182B1 (ko) 2007-11-27 2016-02-05 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
WO2009071696A2 (en) 2007-12-07 2009-06-11 Zymogenetics, Inc. Humanized antibody molecules specific for il-31
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
US20090169484A1 (en) 2007-12-28 2009-07-02 Ihi Corporation Iron-salen complex
KR101597731B1 (ko) 2008-02-21 2016-02-26 센토코 오르토 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
KR20180018839A (ko) 2008-06-30 2018-02-21 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
ES2634445T3 (es) 2008-10-31 2017-09-27 Janssen Biotech, Inc. Diferenciación de las células madre embrionarias humanas con el linaje endocrino pancreático
KR101798474B1 (ko) 2008-10-31 2017-11-16 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 계통으로의 분화
CA2742786A1 (en) * 2008-11-13 2010-05-20 Femta Pharmaceuticals, Inc. Humanized anti-il-6 antibodies
JP5513405B2 (ja) 2008-11-20 2014-06-04 株式会社Ｉｈｉ 自己磁性金属サレン錯体化合物
MX2011005289A (es) 2008-11-20 2011-06-01 Centocor Ortho Biotech Inc Metodos y composiciones para union y cultivo celular sobre sustratos planares.
CN102307991B (zh) 2008-11-20 2017-08-15 森托科尔奥索生物科技公司 微载体上的多能干细胞培养
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
JP5317690B2 (ja) 2008-12-27 2013-10-16 株式会社東芝 メモリシステム
EP2464666B1 (de) * 2009-07-15 2018-03-21 Eva Kovacs-Benke Kombination aus antagonisten des menschlischen interleukin-6- und antagonisten des menschlischen interleukin-6-rezeptors zur behandlung von krebs
US8785184B2 (en) 2009-07-20 2014-07-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
GB2485113B (en) 2009-07-20 2016-12-28 Janssen Biotech Inc Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage
US10076544B2 (en) 2009-07-20 2018-09-18 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2011066371A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
KR101860175B1 (ko) 2009-10-26 2018-05-21 에프. 호프만-라 로슈 아게 글리코실화된 면역글로불린의 제조 방법
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
ES2633648T3 (es) 2009-12-23 2017-09-22 Janssen Biotech, Inc. Diferenciación de células madre embrionarias humanas
RU2701335C2 (ru) 2009-12-23 2019-09-25 Янссен Байотек, Инк. Способ получения популяции панкреатических эндокринных клеток, соэкспрессирующих nkx6.1 и инсулин, и способ лечения диабета
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
RU2702198C2 (ru) 2010-03-01 2019-10-04 Янссен Байотек, Инк. Способы очистки клеток, производных от плюрипотентных стволовых клеток
BR112012028855A2 (pt) 2010-05-12 2015-09-22 Janssen Biotech Inc diferenciação das células-tronco embrionárias humanas
JP6051049B2 (ja) 2010-05-28 2016-12-21 中外製薬株式会社 抗腫瘍ｔ細胞応答増強剤
US9506036B2 (en) 2010-08-31 2016-11-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
US9528090B2 (en) 2010-08-31 2016-12-27 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
MX348537B (es) 2010-08-31 2017-06-07 Janssen Biotech Inc Diferencia de celulas madre pluripotentes.
KR20220070586A (ko) 2010-11-08 2022-05-31 제넨테크, 인크. 피하 투여용 항―ｉｌ―6 수용체 항체
EP2643016A2 (de) 2010-11-23 2013-10-02 Alder Biopharmaceuticals, Inc. Antikörper gegen il6 zur behandlung von anämie
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
JO3370B1 (ar) 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
BR112014015417A8 (pt) 2011-12-22 2017-07-04 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em células positivas de insulina hormonal únicas
RU2664467C2 (ru) 2012-03-07 2018-08-17 Янссен Байотек, Инк. Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток
CN108103005A (zh) 2012-06-08 2018-06-01 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
CA2896658C (en) 2012-12-31 2021-06-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
AU2013370228B2 (en) 2012-12-31 2018-10-18 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
RU2018116647A (ru) 2012-12-31 2018-10-24 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
JP6563910B2 (ja) 2013-07-04 2019-08-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
DK3143127T3 (da) 2014-05-16 2021-09-13 Janssen Biotech Inc Anvendelse af små molekyler til at forstærke mafa-ekspression i endokrine pankreasceller
CA2995645A1 (en) 2015-08-18 2017-02-23 Regeneron Pharmaceuticals, Inc. Anti-pcsk9 inhibitory antibodies for treating patients with hyperlipidemia undergoing lipoprotein apheresis
US11484591B2 (en) 2016-02-22 2022-11-01 Ohio State Innovation Foundation Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
US11033496B2 (en) 2017-03-17 2021-06-15 The Regents Of The University Of Michigan Nanoparticles for delivery of chemopreventive agents
MX2021009242A (es) 2019-01-31 2021-10-26 Sanofi Biotechnology Anticuerpo anti-receptor de il-6 para tratar la artritis juvenil idiopatica.
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2598666B2 (ja) * 1987-10-19 1997-04-09 忠三 岸本 抗ヒトｂｃｄｆモノクローナル抗体
DE3939706C1 (de) * 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
CA2103258A1 (en) * 1991-05-17 1992-11-18 Cory A. Waters Cytokine receptor targeted molecules for treatment of neoplastic cell growth

Also Published As

Publication number Publication date
DE69525971T2 (de) 2002-11-28
JP4079461B2 (ja) 2008-04-23
JP2008063344A (ja) 2008-03-21
EP0800829A1 (de) 1997-10-15
CA2209124A1 (en) 1996-07-11
AU4356896A (en) 1996-07-24
JPH08231433A (ja) 1996-09-10
DE69525971T3 (de) 2013-01-10
JP4812736B2 (ja) 2011-11-09
DE69525971D1 (de) 2002-04-25
US6086874A (en) 2000-07-11
EP0800829B1 (de) 2002-03-20
CN1174507A (zh) 1998-02-25
ES2170815T3 (es) 2002-08-16
AU704723B2 (en) 1999-04-29
CN1075387C (zh) 2001-11-28
HK1001512A1 (en) 1998-06-26
CA2209124C (en) 2010-03-23
EP0800829A4 (de) 1999-12-22
ES2170815T5 (es) 2012-11-14
WO1996020728A1 (fr) 1996-07-11
EP0800829B2 (de) 2012-07-25
KR100252743B1 (ko) 2000-09-01

Similar Documents

Publication Publication Date Title
ATE214602T1 (de) Verstärker eines anti-tumoragens beinhaltend einen il-6 antagonisten
AU6420798A (en) A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
DK1108435T3 (da) Forebyggende midler eller midler mod pancreatitis indeholdende anti-IL-6-receptor-antistoffer som den aktive bestanddel
DK1334731T3 (da) Forebyggende eller terapeutisk middel mod psoriasis omfattende anti-IL-6-receptorantistof som aktiv bestanddel
CY1115472T1 (el) Ενωσεις αμινοετεροαρυλιου ως αναστολεις κινασων πρωτεϊνων
HUP0303952A2 (hu) Terápiás ágens gyermekkori krónikus artrítiszhez hasonló betegségekre
BR0210078A (pt) Composto, uso do mesmo, e, formulação farmacêutica
ATE338565T1 (de) Verwendung eines antagonisten antikörpers gegen den entzündungsmediator oncostatin m (osm)
ATE290594T1 (de) Vegf-c-rezeptorligand
CY1109543T1 (el) Βασικοι μη-πεπτιδικοι ανταγωνιστες βραδυκινινης και 5 φαρμακευτικες συνθεσεις απο αυτους
NO981501D0 (no) Dimer-selektive RXR modulatorer og fremgangsmåter for anvendelse derav
CY1108180T1 (el) Προληπτικα ή/και θεραπευτικα για συστημικο ερυθηματωδη λυκο που περιεχουν αντισωμα αντι-il-6 υποδοχεα ως το δραστικο συστατικο
NO20054078D0 (no) Humane antistoffer spesifikke for Interleukin 15 (IL15).
TR199900090A2 (xx) Benzos�lfon t�revleri
EP2236156A3 (de) Verfahren zur Behandlung und Diagnose von Psoriasis
ATE259375T1 (de) Aminosterinverbindungen als inhibitoren der natrium/proton-pump, pharmazeutische methoden und präparaten davon
DK0929319T3 (da) Dopamin- og serotonintransportörligander og visualiseringsmidler
DE3480902D1 (de) Oral anwendbare antikrebs-zusammensetzungen.
NO980648L (no) Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av metallkomplekser av nitrogeninneholdende makrocykliske ligander
ES2115544A1 (es) Sonda periodontal de medicion digital
TR200001970T2 (tr) MSS bozukluklarının tedavisine mahsus triazin bileşikleri.
TR199900480T2 (xx) Kristalin farmas�tik �r�n.
DE69131522T2 (de) Neuartige glukohydrolase-inhibitoren nützlich als antidiabetische, antivirale und antimetastatische mittel
DE69005241D1 (de) Calcitonin enthaltende pharmazeutische Zusammensetzungen.
ES2151118T3 (es) Evaluacion de substancias para aumentar y para modificar la actividad para la apc.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties