HUE043782T2 - IL-6 elleni antitestek és alkalmazásuk - Google Patents

IL-6 elleni antitestek és alkalmazásuk

Info

Publication number
HUE043782T2
HUE043782T2 HUE16195797A HUE16195797A HUE043782T2 HU E043782 T2 HUE043782 T2 HU E043782T2 HU E16195797 A HUE16195797 A HU E16195797A HU E16195797 A HUE16195797 A HU E16195797A HU E043782 T2 HUE043782 T2 HU E043782T2
Authority
HU
Hungary
Prior art keywords
antibodies
Prior art date
Application number
HUE16195797A
Other languages
English (en)
Inventor
Leon Garcia-Martinez
Anne Elisabeth Carvalho Jensen
Kate Olson
Ben Dutzar
Ethan Ojala
John Latham
Brian Kovacevich
Jeffrey T I Smith
Original Assignee
Alderbio Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alderbio Holdings Llc filed Critical Alderbio Holdings Llc
Publication of HUE043782T2 publication Critical patent/HUE043782T2/hu

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K—PEPTIDES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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HUE16195797A 2007-05-21 2008-05-21 IL-6 elleni antitestek és alkalmazásuk HUE043782T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92455007P 2007-05-21 2007-05-21

Publications (1)

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HUE043782T2 true HUE043782T2 (hu) 2019-09-30

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HUE16195797A HUE043782T2 (hu) 2007-05-21 2008-05-21 IL-6 elleni antitestek és alkalmazásuk
HUE08756095A HUE032563T2 (hu) 2007-05-21 2008-05-21 IL-6 elleni ellenanyagok és alkalmazásuk

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HUE08756095A HUE032563T2 (hu) 2007-05-21 2008-05-21 IL-6 elleni ellenanyagok és alkalmazásuk

Country Status (29)

Country Link
US (4) US20100290993A1 (hu)
EP (2) EP3187506B1 (hu)
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