ATE422205T1 - Verfahren zum screenen von verbindungen, die die produktion von entzündungszytokinen inhibieren - Google Patents

Verfahren zum screenen von verbindungen, die die produktion von entzündungszytokinen inhibieren

Info

Publication number
ATE422205T1
ATE422205T1 AT99949347T AT99949347T ATE422205T1 AT E422205 T1 ATE422205 T1 AT E422205T1 AT 99949347 T AT99949347 T AT 99949347T AT 99949347 T AT99949347 T AT 99949347T AT E422205 T1 ATE422205 T1 AT E422205T1
Authority
AT
Austria
Prior art keywords
production
inflammatory cytokines
inhibit
screening compounds
inflammatory
Prior art date
Application number
AT99949347T
Other languages
English (en)
Inventor
Masayuki Tsuchiya
Toshihiko Ohtomo
Yasuhiro Sugamata
Kunihiro Matsumoto
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE422205T1 publication Critical patent/ATE422205T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99949347T 1998-10-21 1999-10-21 Verfahren zum screenen von verbindungen, die die produktion von entzündungszytokinen inhibieren ATE422205T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29996298 1998-10-21

Publications (1)

Publication Number Publication Date
ATE422205T1 true ATE422205T1 (de) 2009-02-15

Family

ID=17879081

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99949347T ATE422205T1 (de) 1998-10-21 1999-10-21 Verfahren zum screenen von verbindungen, die die produktion von entzündungszytokinen inhibieren

Country Status (6)

Country Link
US (3) US6989244B1 (de)
EP (1) EP1127944B9 (de)
AT (1) ATE422205T1 (de)
AU (1) AU6227899A (de)
DE (1) DE69940383D1 (de)
WO (1) WO2000023610A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6227899A (en) * 1998-10-21 2000-05-08 Chugai Seiyaku Kabushiki Kaisha Method for screening compound inhibiting signal transduction of inflammatory cytokine
GB0306071D0 (en) * 2003-03-17 2003-04-23 Novartis Ag Organic compounds
EP1608755B1 (de) * 2003-04-01 2012-10-17 Helmholtz-Zentrum für Infektionsforschung GmbH Tak1-vermittelte hemmung der osteogenese
US20050287565A1 (en) * 2004-05-12 2005-12-29 Merchiers Pascal G Methods, compositions and compound assays for inhibiting amyloid-beta protein production
WO2008005418A2 (en) * 2006-06-30 2008-01-10 The Trustees Of Columbia University In The City Of New York Assays for tak1 activity
WO2008018517A1 (fr) * 2006-08-09 2008-02-14 Zeria Pharmaceutical Co., Ltd. Agent thérapeutique et/ou préventif pour une maladie s'accompagnant d'une croissance cellulaire exagérée, et polynucléotide utile en tant que principe actif
US7736860B2 (en) * 2006-11-09 2010-06-15 Univeristy Of Massachusetts Methods of identifying compounds for the treatment of sterile inflammation
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
MX2009012493A (es) * 2007-05-21 2010-01-20 Alder Biopharmaceuticals Inc Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados.
ES2610607T3 (es) 2007-05-21 2017-04-28 Alderbio Holdings Llc Anticuerpos contra IL-6 y usos de los mismos
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US8323649B2 (en) * 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US9724410B2 (en) 2009-11-24 2017-08-08 Alderbio Holdings Llc Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
AU2011332817A1 (en) 2010-11-23 2013-06-13 Alder Biopharmaceuticals, Inc. Anti-IL-6 antibodies for the treatment of anemia
EP2943579B1 (de) * 2013-01-10 2018-09-12 Dharmacon, Inc. Bibliotheken und verfahren zur erzeugung von molekülen
WO2018060452A1 (en) * 2016-09-30 2018-04-05 Fundació Institut Mar D'investigacions Mèdiques (Imim) Therapeutic approaches to cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2345497A1 (en) * 1988-10-28 1990-04-28 Genentech, Inc. Growth hormone variants and method for forming growth hormone variants
US5945301A (en) 1995-09-29 1999-08-31 Chugai Seiyaku Kabushiki Kaisha Kinase in TGF-β family signal transduction system
EP0803571B1 (de) 1996-04-24 2004-11-24 Chugai Seiyaku Kabushiki Kaisha TAB1 Protein und dafür kodierende DNA
JP3907247B2 (ja) 1996-04-24 2007-04-18 中外製薬株式会社 Ｔａｂ１蛋白質及びそれをコードするｄｎａ
AU2043597A (en) 1996-07-24 1998-02-10 Chugai Seiyaku Kabushiki Kaisha Human taki dna encoding the same
FR2751687B1 (fr) 1996-07-26 1999-01-15 Coudert Michel Abri pliable equipe de poutres articulees a parallelogrammes deformables
KR20010031325A (ko) 1997-10-22 2001-04-16 나가야마 오사무 티지에프-베타 저해물질의 스크리닝 방법
WO1999040202A1 (en) 1998-02-06 1999-08-12 Tanabe Seiyaku Co., Ltd. NF-λB ACTIVATION INHIBITORS TARGETING ON TAK1 AND METHOD FOR IDENTIFYING THE SAME
JP2000197500A (ja) 1998-02-06 2000-07-18 Tanabe Seiyaku Co Ltd ＴＡＫ１を標的とするＮＦ―κＢ活性化抑制薬及びその同定方法
AU6227899A (en) * 1998-10-21 2000-05-08 Chugai Seiyaku Kabushiki Kaisha Method for screening compound inhibiting signal transduction of inflammatory cytokine

Also Published As

Publication number Publication date
US20060040316A1 (en) 2006-02-23
US8105799B2 (en) 2012-01-31
WO2000023610A1 (fr) 2000-04-27
EP1127944B1 (de) 2009-02-04
AU6227899A (en) 2000-05-08
EP1127944B9 (de) 2009-08-12
EP1127944A4 (de) 2004-12-29
US6989244B1 (en) 2006-01-24
US20080160541A1 (en) 2008-07-03
EP1127944A1 (de) 2001-08-29
DE69940383D1 (de) 2009-03-19

Similar Documents

Publication Publication Date Title
ATE422205T1 (de) Verfahren zum screenen von verbindungen, die die produktion von entzündungszytokinen inhibieren
ATE544299T1 (de) Verfahren und system zum kalibrieren von mikrofonen
ATE402518T1 (de) Verfahren zum bestimmen eines numerischen wertes für die zeitliche dauer eines sich periodisch wiederholenden impulsförmigen signals, und vorrichtung zur durchführung eines solchen verfahrens
IT1172283B (it) Apparecchio per la prospezione di pozzi ad onde acustiche
EP0863757A4 (de)
ATE451930T1 (de) Verwendung von il-18-hemmern zur behandlung oder prävention von sepsis
NO971684D0 (no) Nye benzoxazoler
DE69023722D1 (de) Mehrkanal-Tonsystem.
IT7824956A0 (it) Colonna montante disimpegnabile per pozzi petroliferi sottomarini.
DE50208467D1 (de) Schaltungsanordnung zur Verbesserung der Verständlichkeit von Sprache enthaltenden Audiosignalen
DE69013334D1 (de) Geräuschreduzierungsverfahren für bohrgestängesignale.
MXPA05010630A (es) Compuestos de benzopirano utiles para tratar estados inflamatorios.
DE3586161D1 (de) Verfahren zur synthese von ammoniak.
DE3177166D1 (de) Vorrichtung zur sprachsynthese.
FI20002504A (fi) Menetelmä radiokanavan simuloimiseksi ja kanavasimulaattori
FR2849246B1 (fr) Procede de determination du caractere vivant d'un element porteur d'une empreinte digitale
FR2849244B1 (fr) Procede de determination du caractere vivant d'un element porteur d'une empreinte digitale
DE60239365D1 (de) Screeningverfahren für einen Eingeweideschmerzhemmer
IT7827683A0 (it) Procedimento per produrre superfici indurite mediante tempra di rifusione.
DE60203543D1 (de) Verfahren zum Erkennen der Quantisierung von Spektren
IT8423959V0 (it) Cassa acustica singola ad effetto spaziale per impianti di riproduzione musicale.
AT379157B (de) Verfahren zur diskontinuierlichen herstellung von polymeren, die sich vom p-phenylendiamin ableiten
ATE245320T1 (de) Verfahren zur gleichzeitigen messung der impulsantworten von mehreren funkkanälen
DE60105997D1 (de) Verfahren zum einstellen der härte von fischer-tropschwachs durch mischung
DE3485463D1 (de) Vorrichtung zur anpassung der tonhoehe.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties