MX2009012493A - Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados. - Google Patents
Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados.Info
- Publication number
- MX2009012493A MX2009012493A MX2009012493A MX2009012493A MX2009012493A MX 2009012493 A MX2009012493 A MX 2009012493A MX 2009012493 A MX2009012493 A MX 2009012493A MX 2009012493 A MX2009012493 A MX 2009012493A MX 2009012493 A MX2009012493 A MX 2009012493A
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
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Abstract
La presente invención se dirige a métodos novedosos y mejorados para humanizar regiones variables pesada y ligera de conejo. Las cadenas pesada y ligera de conejo humanizadas resultantes y anticuerpos y fragmentos de anticuerpo que contienen son bien adecuadas para el uso en la inmunoterapia e inmunodiagnosis ya que retienen la afinidad de enlace de antígeno del anticuerpo de origen y basado en su nivel muy alto de identidad de secuencia a las secuencias de anticuerpo humanas deben ser esencialmente no inmunogénicas en humanos. La invención ejemplifica el protocolo para la manufactura de anticuerpos anti-TNF-alfa humana y anti-IL-6 humana humanizados terapéuticos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92455107P | 2007-05-21 | 2007-05-21 | |
US92455007P | 2007-05-21 | 2007-05-21 | |
US11/802,235 US20070269868A1 (en) | 2006-05-19 | 2007-05-21 | Culture method for obtaining a clonal population of antigen-specific B cells |
PCT/US2008/064421 WO2008144757A1 (en) | 2007-05-21 | 2008-05-21 | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009012493A true MX2009012493A (es) | 2010-01-20 |
Family
ID=40122218
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011661A MX343879B (es) | 2007-05-21 | 2008-05-21 | Metodo de humanizacion de anticuerpo de conejo novedoso y anticuerpos de conejo humanizados. |
MX2009012493A MX2009012493A (es) | 2007-05-21 | 2008-05-21 | Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011661A MX343879B (es) | 2007-05-21 | 2008-05-21 | Metodo de humanizacion de anticuerpo de conejo novedoso y anticuerpos de conejo humanizados. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20090104187A1 (es) |
EP (1) | EP2162469A4 (es) |
JP (1) | JP5859202B2 (es) |
KR (3) | KR20170036814A (es) |
CN (1) | CN101868477A (es) |
AU (1) | AU2008254578B2 (es) |
CA (1) | CA2688829A1 (es) |
IL (1) | IL202232A (es) |
MX (2) | MX343879B (es) |
NO (1) | NO20093386L (es) |
NZ (2) | NZ601583A (es) |
TW (2) | TWI501976B (es) |
WO (1) | WO2008144757A1 (es) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
US8404235B2 (en) * | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
KR101615715B1 (ko) | 2007-05-21 | 2016-04-27 | 앨더바이오 홀딩스 엘엘씨 | Il-6에 대한 항체 및 이의 용도 |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
ES2890405T3 (es) | 2008-06-25 | 2022-01-19 | Novartis Ag | Humanización de anticuerpos de conejo usando un armazón de anticuerpo universal |
EP3444274B1 (en) | 2008-06-25 | 2020-12-23 | Novartis AG | Stable and soluble antibodies inhibiting tnf |
CN104004094B (zh) | 2008-06-25 | 2017-09-22 | 艾斯巴技术-诺华有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
WO2010065077A2 (en) * | 2008-11-25 | 2010-06-10 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to prevent or treat thrombosis |
US8420089B2 (en) * | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
US8399624B1 (en) | 2009-06-25 | 2013-03-19 | Esbatech, An Alcon Biomedical Research Unit Llc | Acceptor framework for CDR grafting |
CN102002104A (zh) | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
JP5934652B2 (ja) | 2009-11-24 | 2016-06-15 | アルダーバイオ ホールディングス エルエルシー | Il−6に対する抗体およびその使用 |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
RU2567804C2 (ru) * | 2009-12-22 | 2015-11-10 | Ф. Хоффманн-Ля Рош Аг | Агрегация, зависящая от последовательностей |
JP6027744B2 (ja) * | 2009-12-25 | 2016-11-16 | 積水メディカル株式会社 | ヒトインスリン測定方法及び測定試薬 |
KR20130010123A (ko) * | 2010-04-07 | 2013-01-25 | 아비에 인코포레이티드 | TNF-α 결합 단백질 |
UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
EP2643016A2 (en) | 2010-11-23 | 2013-10-02 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of anemia |
AU2011336470B8 (en) | 2010-12-01 | 2017-09-14 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US8597883B2 (en) | 2011-02-14 | 2013-12-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for cancer-related fatigue and use thereof |
CN106928362B (zh) | 2011-04-29 | 2021-10-26 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
AU2012258980B8 (en) | 2011-05-20 | 2017-06-15 | H. Lundbeck A/S | Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
LT2710114T (lt) | 2011-05-20 | 2021-12-10 | H. Lundbeck A/S | Gamyba aukšto grynumo iš keleto subvienetų sudarytų baltymų, tokių kaip antikūnai, transformuotuose mikroorganizmuose, tokiuose kaip pichia pastoris |
CN108424452B (zh) | 2011-05-20 | 2021-08-03 | H.伦德贝克公司 | 抗cgrp组合物及其用途 |
NZ717704A (en) | 2011-05-20 | 2022-08-26 | H Lundbeck As | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
AU2012299035B2 (en) | 2011-08-19 | 2017-11-02 | H. Lundbeck A/S | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
ES2879552T3 (es) | 2012-10-30 | 2021-11-22 | Apexigen Inc | Anticuerpos anti-CD40 y métodos de uso |
CA2894918A1 (en) | 2013-02-15 | 2014-08-21 | Esbatech - A Novartis Company Llc | Acceptor framework for cdr grafting |
EP2958939A1 (en) | 2013-02-20 | 2015-12-30 | ESBATech - a Novartis Company LLC | Acceptor framework for cdr grafting |
US20160024203A1 (en) * | 2013-03-15 | 2016-01-28 | Bristol-Myers Squibb Company | Methods of producing antibodies in yeast |
US10138294B2 (en) | 2013-03-15 | 2018-11-27 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
WO2014145744A1 (en) | 2013-03-15 | 2014-09-18 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
AU2014301629B2 (en) | 2013-06-26 | 2020-02-06 | Numab Therapeutics AG | Novel antibody frameworks |
IL243355B1 (en) | 2013-07-03 | 2024-06-01 | Lundbeck Seattle Biopharmaceuticals Inc | Regulation of glucose metabolism using an anti-CGRP antibody |
CR20160270A (es) | 2013-12-20 | 2016-09-05 | Hoffmann La Roche | ANTICUERPOS ANTI-TAU (pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN |
MA40835A (fr) * | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
AU2016249839B2 (en) * | 2015-04-17 | 2021-09-09 | Ventana Medical Systems, Inc. | Antibodies, compositions, and immunohistochemistry methods for detecting C4.4a |
WO2016173719A1 (en) * | 2015-04-30 | 2016-11-03 | Abcheck S.R.O. | Method for mass humanization of rabbit antibodies |
EP3305325A4 (en) | 2015-06-04 | 2019-01-16 | National Center of Neurology and Psychiatry | ACTIVE AGENT FOR THE THERAPY OF MENTAL ILLNESSES WITH IL-6 INHIBITOR AS AN ACTIVE AGENT |
GB201510758D0 (en) * | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
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MX343879B (es) | 2016-11-25 |
JP5859202B2 (ja) | 2016-02-10 |
TWI609965B (zh) | 2018-01-01 |
JP2010528589A (ja) | 2010-08-26 |
AU2008254578B2 (en) | 2013-06-06 |
TWI501976B (zh) | 2015-10-01 |
IL202232A0 (en) | 2010-06-16 |
KR20100028571A (ko) | 2010-03-12 |
NZ581418A (en) | 2012-08-31 |
TW200902720A (en) | 2009-01-16 |
WO2008144757A1 (en) | 2008-11-27 |
CA2688829A1 (en) | 2008-11-27 |
CN101868477A (zh) | 2010-10-20 |
KR20170036814A (ko) | 2017-04-03 |
EP2162469A1 (en) | 2010-03-17 |
NZ601583A (en) | 2013-08-30 |
US20090104187A1 (en) | 2009-04-23 |
KR20160005134A (ko) | 2016-01-13 |
IL202232A (en) | 2015-11-30 |
NO20093386L (no) | 2010-02-18 |
TW200911826A (en) | 2009-03-16 |
AU2008254578A1 (en) | 2008-11-27 |
EP2162469A4 (en) | 2012-08-01 |
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