SI3187506T1 - Protitelesa proti IL-6 in njihova uporaba - Google Patents

Protitelesa proti IL-6 in njihova uporaba

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Publication number
SI3187506T1
SI3187506T1 SI200832074T SI200832074T SI3187506T1 SI 3187506 T1 SI3187506 T1 SI 3187506T1 SI 200832074 T SI200832074 T SI 200832074T SI 200832074 T SI200832074 T SI 200832074T SI 3187506 T1 SI3187506 T1 SI 3187506T1
Authority
SI
Slovenia
Prior art keywords
antibodies
Prior art date
Application number
SI200832074T
Other languages
English (en)
Inventor
Leon Garcia-Martinez
Anne Elisabeth Carvalho Jensen
Kate Olson
Ben Dutzar
Ethan Ojala
John Latham
Brian Kovacevich
Jeffrey T.I. SMITH
Original Assignee
Alderbio Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alderbio Holdings Llc filed Critical Alderbio Holdings Llc
Publication of SI3187506T1 publication Critical patent/SI3187506T1/sl

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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07ORGANIC CHEMISTRY
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
SI200832074T 2007-05-21 2008-05-21 Protitelesa proti IL-6 in njihova uporaba SI3187506T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92455007P 2007-05-21 2007-05-21
EP16195797.2A EP3187506B1 (en) 2007-05-21 2008-05-21 Antibodies to il-6 and use thereof

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SI3187506T1 true SI3187506T1 (sl) 2019-08-30

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SI200832074T SI3187506T1 (sl) 2007-05-21 2008-05-21 Protitelesa proti IL-6 in njihova uporaba
SI200831772A SI2164514T1 (sl) 2007-05-21 2008-05-21 Protitelesa proti IL-6 in njihova uporaba

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US (4) US7935340B2 (sl)
EP (2) EP3187506B1 (sl)
JP (4) JP5833823B2 (sl)
KR (3) KR101829776B1 (sl)
CN (2) CN105001332B (sl)
AU (1) AU2008254584B2 (sl)
BR (1) BRPI0811782A2 (sl)
CA (2) CA2993715A1 (sl)
CO (1) CO6241159A2 (sl)
CY (2) CY1119068T1 (sl)
DK (2) DK3187506T3 (sl)
EA (1) EA200901533A1 (sl)
ES (2) ES2721753T3 (sl)
HK (1) HK1138796A1 (sl)
HR (2) HRP20170038T1 (sl)
HU (2) HUE032563T2 (sl)
IL (4) IL202238A (sl)
LT (2) LT2164514T (sl)
MX (2) MX2009012492A (sl)
NO (2) NO344119B1 (sl)
NZ (2) NZ581596A (sl)
PL (2) PL3187506T3 (sl)
PT (2) PT2164514T (sl)
SG (1) SG183742A1 (sl)
SI (2) SI3187506T1 (sl)
TR (1) TR201905366T4 (sl)
TW (2) TWI617576B (sl)
WO (1) WO2008144763A2 (sl)
ZA (1) ZA200908770B (sl)

Families Citing this family (91)

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CN101330930B (zh) * 2005-10-21 2011-11-23 中外制药株式会社 心脏病治疗剂
US9260516B2 (en) 2006-04-07 2016-02-16 Osaka University Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor
AU2008208321B2 (en) 2007-01-23 2013-03-21 Chugai Seiyaku Kabushiki Kaisha Chronic rejection inhibitor
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
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