MX2008014692A - Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno. - Google Patents

Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno.

Info

Publication number
MX2008014692A
MX2008014692A MX2008014692A MX2008014692A MX2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A MX 2008014692 A MX2008014692 A MX 2008014692A
Authority
MX
Mexico
Prior art keywords
antigen
cells
obtaining
specific
culture method
Prior art date
Application number
MX2008014692A
Other languages
English (en)
Inventor
John Latham
Leon Garcia
Anne Elisabeth Carvalho
Ethan Ohala
Original Assignee
Alder Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39283142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2008014692(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alder Biopharmaceuticals Inc filed Critical Alder Biopharmaceuticals Inc
Publication of MX2008014692A publication Critical patent/MX2008014692A/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0635B lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells

Abstract

La presente invención se relaciona a métodos de aislamiento de células específicas de antígeno y producción de anticuerpos de las mismas.
MX2008014692A 2006-05-19 2007-05-21 Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno. MX2008014692A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80141206P 2006-05-19 2006-05-19
PCT/US2007/011980 WO2008045140A1 (en) 2006-05-19 2007-05-21 Culture method for obtaining a clonal population of antigen-specific b cells

Publications (1)

Publication Number Publication Date
MX2008014692A true MX2008014692A (es) 2009-08-18

Family

ID=39283142

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008014692A MX2008014692A (es) 2006-05-19 2007-05-21 Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno.

Country Status (12)

Country Link
US (3) US20070269868A1 (es)
EP (1) EP2021463B1 (es)
JP (1) JP5607357B2 (es)
CN (1) CN101600793B (es)
AU (1) AU2007307324B2 (es)
CA (1) CA2652392C (es)
DK (1) DK2021463T3 (es)
IL (1) IL195285A (es)
MX (1) MX2008014692A (es)
NO (1) NO20084835L (es)
NZ (1) NZ572807A (es)
WO (1) WO2008045140A1 (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
JP5833823B2 (ja) 2007-05-21 2015-12-16 アルダーバイオ・ホールディングズ・エルエルシー Il−6に対する抗体およびその使用
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
EP2361095B1 (en) * 2008-11-25 2017-12-20 AlderBio Holdings LLC Antagonists of il-6 to raise albumin and/or lower crp
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9079942B2 (en) * 2009-02-09 2015-07-14 Epitomics, Inc. CDR-anchored amplification method
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
WO2011066371A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
AU2010289677B2 (en) 2009-09-03 2014-07-31 Merck Sharp & Dohme Llc Anti-GITR antibodies
US8293483B2 (en) 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
TWI667346B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的FcRn親和力之抗體
PL2400298T3 (pl) * 2010-05-28 2014-01-31 Hoffmann La Roche Sposób hodowania pojedynczych komórek b oraz wytwarzania swoistych przeciwciał
CA2818813C (en) 2010-11-23 2020-10-06 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of oral mucositis
US8911734B2 (en) 2010-12-01 2014-12-16 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
JP5963746B2 (ja) * 2011-03-30 2016-08-03 国立大学法人富山大学 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体
CA2836799C (en) 2011-05-20 2021-05-18 Alderbio Holdings Llc Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
US9708393B2 (en) 2011-05-20 2017-07-18 Alderbio Holdings Llc Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
EP3662932B1 (en) 2011-05-20 2021-04-07 H. Lundbeck A/S Anti-cgrp compositions and use thereof
EP2724157B1 (en) * 2011-06-27 2017-03-08 Valneva Method for screening cells
AU2012315616C1 (en) 2011-09-28 2016-11-03 Jian Han Identification of antigen-specific adaptive immune responses using Arm-PCR and high-throughput sequencing
KR102069394B1 (ko) 2011-11-23 2020-01-22 에프. 호프만-라 로슈 아게 Cd40l 발현 포유류 세포 및 그의 용도
JP2015500655A (ja) 2011-12-21 2015-01-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 同起源の抗体可変領域遺伝子セグメントをクローニングおよび発現させるための迅速な方法
US20150259430A1 (en) 2012-11-05 2015-09-17 Mab Discovery Gmbh Method for the production of multispecific antibodies
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
EP2727943A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispecific antibodies against human EGFR, HER2 and HER3
EP2727942A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispecific antibodies against human EGFR, HER2, and HER3
CN104903349B (zh) 2012-11-08 2018-10-19 十一生物治疗股份有限公司 Il-6拮抗剂及其应用
AU2013344992A1 (en) * 2012-11-13 2015-05-14 Genentech, Inc. Enrichment of antigen-specific plasmablasts
CN104884470A (zh) * 2013-02-15 2015-09-02 艾斯巴技术-诺华有限责任公司 用于cdr移植的接受体框架
CN105246915A (zh) * 2013-03-14 2016-01-13 奥尔德生物制药公司 Hgf抗体及含有其的组合物
AR095615A1 (es) 2013-03-15 2015-10-28 Alder Biopharmaceuticals Inc Purificación de anticuerpos y monitoreo de pureza
AU2014232225B2 (en) * 2013-03-15 2020-03-19 H. Lundbeck A/S. Protocol for identifying and isolating antigen-specific B cells and producing antibodies to desired antigens
TWI636136B (zh) 2013-03-15 2018-09-21 艾爾德生物製藥股份有限公司 在酵母菌及其它轉型細胞中多肽高產量表現用之溫度變動技術
US20160075766A1 (en) 2013-05-21 2016-03-17 Roche Diagnostics Operations, Inc. Method for producing antibodies using ovine b-cells and uses thereof
CN104232577B (zh) * 2013-06-20 2017-12-01 中国人民解放军军事医学科学院基础医学研究所 一种获得自身反应性b细胞的方法
ES2911690T3 (es) 2013-07-03 2022-05-20 H Lundbeck As Regulación del metabolismo de la glucosa mediante anticuerpos anti-CGRP
SG10202103420PA (en) 2014-11-07 2021-05-28 Eleven Biotherapeutics Inc Improved il-6 antibodies
EP3271393A4 (en) 2015-03-18 2018-10-31 Epitomics, Inc. High throughput monoclonal antibody generation by b cell panning and proliferation
WO2016195088A1 (ja) 2015-06-04 2016-12-08 国立研究開発法人 国立精神・神経医療研究センター Il-6阻害剤を有効成分とする精神疾患治療剤
CA2990305A1 (en) 2015-06-26 2016-12-29 Mab Discovery Gmbh Monoclonal anti-il-1racp antibodies
WO2017167714A1 (en) 2016-03-30 2017-10-05 F. Hoffmann-La Roche Ag B-cell cultivation method
CN109451728A (zh) 2016-04-15 2019-03-08 奥尔德生物制药公司 抗pacap抗体及其用途
EP3241845A1 (en) 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
CN106350485B (zh) * 2016-08-24 2020-02-21 杭州百凌生物科技有限公司 一种快速高效分离单个抗原特异性b细胞的方法
JP6916884B2 (ja) 2017-01-02 2021-08-11 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft B細胞培養法
EP3401332A1 (en) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
JP6978516B2 (ja) 2017-05-19 2021-12-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 胸腺細胞上清を産生するための方法
US11125757B2 (en) * 2017-05-26 2021-09-21 Emory University Methods of culturing and characterizing antibody secreting cells
EP3717632B1 (en) 2017-11-30 2022-10-26 F. Hoffmann-La Roche AG B-cell cultivation method
CN114144436A (zh) 2019-07-24 2022-03-04 H.隆德贝克有限公司 抗mGluR5抗体及其用途
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
JPWO2022004620A1 (es) * 2020-06-29 2022-01-06
WO2022241415A1 (en) * 2021-05-11 2022-11-17 Yale University Methods for monoclonal antibody generation

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6657103B1 (en) * 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1991017177A1 (en) * 1990-05-04 1991-11-14 Baxter Diagnostics Inc. High affinity antibodies to small peptides
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
EP0488470B1 (en) * 1990-11-26 1997-05-28 Akzo Nobel N.V. Method for the production of antibodies
US6277969B1 (en) * 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5256542A (en) * 1992-03-09 1993-10-26 Tanox Biosystems, Inc. Selecting low frequency antigen-specific single B lymphocytes with correction for background noise
US6972125B2 (en) * 1999-02-12 2005-12-06 Genetics Institute, Llc Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
WO2004039826A1 (en) * 2001-11-14 2004-05-13 Centocor, Inc. Anti-il-6 antibodies, compositions, methods and uses
US20040185040A1 (en) * 2001-11-21 2004-09-23 Celltech R & D Limited Modulating immune responses
US8188231B2 (en) * 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
EP1570267B1 (en) 2002-12-03 2011-10-12 UCB Pharma, S.A. Assay for identifying antibody producing cells
GB0312481D0 (en) * 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
AU2003259718A1 (en) * 2003-08-07 2005-03-07 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
EP1658500B1 (en) 2003-08-20 2012-04-18 UCB Pharma, S.A. Methods for obtaining antibodies
WO2005019823A1 (en) 2003-08-20 2005-03-03 Celltech R & D Limited Methods for obtaining antibodies
CN1871259A (zh) * 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 具有改变的效应物功能的经改进的抗体和制备它的方法
CA2536675A1 (en) * 2003-08-29 2005-03-10 Centocor, Inc. A rapid way to obtain high expression clones of mammalian cells using a methylcellulose and immunoprecipitation screening method
JP4994038B2 (ja) * 2003-10-22 2012-08-08 ケック グラジュエイト インスティチュート 一倍体接合方法を用いた酵母におけるヘテロ多量体のポリペプチド類の合成方法
GB0412973D0 (en) 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
US20060051348A1 (en) * 2004-09-09 2006-03-09 Jorn Gorlach Method of producing a plurality of isolated antibodies to a plurality of cognate antigens
US7968308B2 (en) * 2004-10-22 2011-06-28 Danisco Us Inc. Isolating human antibodies
US7462697B2 (en) * 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
PE20061324A1 (es) * 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
US20070092943A1 (en) * 2005-09-28 2007-04-26 The University Of Chicago Versatile vectors for expression of foreign proteins in photosynthetic bacteria

Also Published As

Publication number Publication date
JP2009537176A (ja) 2009-10-29
WO2008045140A1 (en) 2008-04-17
EP2021463A4 (en) 2009-09-02
NZ572807A (en) 2011-10-28
CN101600793B (zh) 2013-06-26
DK2021463T3 (en) 2017-01-16
US20130316353A1 (en) 2013-11-28
CA2652392A1 (en) 2008-04-17
IL195285A (en) 2012-07-31
US20120141982A1 (en) 2012-06-07
EP2021463A1 (en) 2009-02-11
AU2007307324B2 (en) 2013-08-15
US20070269868A1 (en) 2007-11-22
IL195285A0 (en) 2011-08-01
CA2652392C (en) 2017-10-10
NO20084835L (no) 2009-02-16
JP5607357B2 (ja) 2014-10-15
AU2007307324A1 (en) 2008-04-17
EP2021463B1 (en) 2016-11-23
CN101600793A (zh) 2009-12-09

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