HRP20221538T1 - Anti-transtiretinska antitijela - Google Patents
Anti-transtiretinska antitijela Download PDFInfo
- Publication number
- HRP20221538T1 HRP20221538T1 HRP20221538TT HRP20221538T HRP20221538T1 HR P20221538 T1 HRP20221538 T1 HR P20221538T1 HR P20221538T T HRP20221538T T HR P20221538TT HR P20221538 T HRP20221538 T HR P20221538T HR P20221538 T1 HRP20221538 T1 HR P20221538T1
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- Prior art keywords
- heavy chain
- antibody
- seq
- mature
- variable region
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 108010071690 Prealbumin Proteins 0.000 claims 4
- 102000009190 Transthyretin Human genes 0.000 claims 4
- 206010002022 amyloidosis Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000003259 recombinant expression Methods 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 210000003403 autonomic nervous system Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (15)
1. Humanizirano antitijelo koje se veže na transtiretin i sadrži varijabilnu regiju zrelog teškog lanca SEQ ID NO: 11 i varijabilnu regiju zrelog lakog lanca SEQ ID NO: 19, ili varijabilnu regiju zrelog teškog lanca SEQ ID NO: 65 i varijabilnu regiju zrelog lakog lanca SEQ ID NO: 76.
2. Antitijelo prema zahtjevu 1 koje ima ljudski IgG1 izotip.
3. Antitijelo prema zahtjevu 1 koje ima ljudski IgG2 ili IgG4 izotip.
4. Antitijelo prema zahtjevu 1 koje je vezni fragment, izborno gdje je vezni fragment jedno-lančano antitijelo, Fab, ili F(ab’)2 fragment.
5. Antitijelo prema bilo kojem od zahtjeva 1-3, naznačeno time što je varijabilna regija zrelog lakog lanca spojena s konstantnom regijom lakog lanca i varijabilna regija zrelog teškog lanca spojena je s konstantnom regijom teškog lanca.
6. Antitijelo prema zahtjevu 5, naznačeno time što je konstantna regija teškog lanca mutantni oblik prirodne konstantne regije ljudskog teškog lanca koja ima smanjeno vezanje na Fcγ receptor u odnosu na prirodnu konstantnu regiju ljudskog teškog lanca.
7. Antitijelo prema zahtjevu 5, naznačeno time što je konstantna regija teškog lanca IgG1 izotipa, izborno gdje je varijabilna regija zrelog teškog lanca spojena na konstantnu regiju teškog lanca koja ima sekvencu SEQ ID NO: 103 sa ili bez C-terminalnog lizina i/ili je zrela varijabilna regija lakog lanca spojena na konstantnu regiju lakog lanca koja ima sekvencu SEQ ID NO: 104 ili 105.
8. Antitijelo prema zahtjevu 1, koje sadrži zreli teški lanac koji ima sekvencu SEQ ID NO: 82 sa ili bez C-terminalnog lizina i zreli laki lanac koji ima sekvencu SEQ ID NO: 86.
9. Farmaceutski pripravak koji sadrži antitijelo prema bilo kojem prethodnom zahtjevu i farmaceutski prihvatljiv nosač.
10. Nukleinska kiselina ili nukleinske kiseline koje kodiraju teški lanac i laki lanac antitijela kako je opisano u bilo kojem od zahtjeva 1-8, izborno imaju sekvencu koja sadrži bilo koju od SEQ ID NOS: 50, 52, 92 i 96.
11. Rekombinantni ekspresijski vektor koji sadrži nukleinsku kiselinu prema zahtjevu 10 ili rekombinantne ekspresijske vektore koji sadrže nukleinske kiseline prema zahtjevu 10.
12. Stanica domaćina transformirana s rekombinantnim ekspresijskim vektorom(ima) prema zahtjevu 11.
13. Postupak proizvodnje antitijela prema zahtjevu 1, naznačen time što postupak sadrži:
(a) uzgoj stanica transformiranih nukleinskim kiselinama koje kodiraju teške i lake lance antitijela, tako da stanice luče antitijelo; i
(b) pročišćavanje antitijela iz medija stanične kulture.
14. Antitijelo prema bilo kojem od zahtjeva 1-8 za uporabu u liječenju ili učinku na profilaksu transtiretinom posredovane amiloidoze, ili odgađanje početka transtiretinom posredovane amiloidoze kod subjekta.
15. In vitro postupak dijagnosticiranja transtiretinom posredovane amiloidoze kod subjekta, koji sadrži kontaktiranje biološkog uzorka od subjekta s učinkovitom količinom antitijela prema bilo kojem od zahtjeva 1-8, izborno gdje je biološki uzorak i/ili kontrolni uzorak krv, serum, plazma, ili čvrsto tkivo; izborno pri čemu je čvrsto tkivo iz srca, perifernog živčanog sustava, autonomnog živčanog sustava, bubrega, očiju, ili gastrointestinalnog trakta.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109002P | 2015-01-28 | 2015-01-28 | |
| US201562266556P | 2015-12-11 | 2015-12-11 | |
| PCT/IB2016/050415 WO2016120810A1 (en) | 2015-01-28 | 2016-01-28 | Anti-transthyretin antibodies |
| EP16702812.5A EP3250592B1 (en) | 2015-01-28 | 2016-01-28 | Anti-transthyretin antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20221538T1 true HRP20221538T1 (hr) | 2023-03-03 |
Family
ID=55299694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20221538TT HRP20221538T1 (hr) | 2015-01-28 | 2016-01-28 | Anti-transtiretinska antitijela |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20160251418A1 (hr) |
| EP (2) | EP4134379A1 (hr) |
| JP (2) | JP6748086B2 (hr) |
| KR (2) | KR102598180B1 (hr) |
| CN (1) | CN107406499B (hr) |
| AU (1) | AU2016210888C1 (hr) |
| BR (1) | BR112017016330A2 (hr) |
| CA (1) | CA2974912A1 (hr) |
| CL (2) | CL2017001924A1 (hr) |
| CO (1) | CO2017008476A2 (hr) |
| CU (1) | CU24480B1 (hr) |
| DK (1) | DK3250592T3 (hr) |
| EA (1) | EA036080B1 (hr) |
| ES (1) | ES2934656T3 (hr) |
| FI (1) | FI3250592T3 (hr) |
| HR (1) | HRP20221538T1 (hr) |
| HU (1) | HUE060878T2 (hr) |
| IL (1) | IL253633B (hr) |
| LT (1) | LT3250592T (hr) |
| MX (1) | MX2017009806A (hr) |
| PE (1) | PE20180217A1 (hr) |
| PH (1) | PH12017501318B1 (hr) |
| PL (1) | PL3250592T3 (hr) |
| PT (1) | PT3250592T (hr) |
| RS (1) | RS63906B1 (hr) |
| SA (1) | SA517382002B1 (hr) |
| SG (2) | SG11201706124VA (hr) |
| SI (1) | SI3250592T1 (hr) |
| TW (2) | TWI718122B (hr) |
| UA (1) | UA122142C2 (hr) |
| WO (1) | WO2016120810A1 (hr) |
| ZA (1) | ZA201705663B (hr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| WO2018007922A2 (en) * | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| CU20200022A7 (es) * | 2017-10-06 | 2021-01-12 | Prothena Biosciences Ltd | Métodos para detectar transtiretina |
| EP3691447A4 (en) | 2017-10-06 | 2021-08-11 | Prothena Biosciences Limited | ANTI-TRANSTHYRETINE ANTIBODIES |
| AU2018375356A1 (en) | 2017-11-29 | 2020-05-14 | Neotope Neuroscience Limited | Lyophilized formulation of a monoclonal antibody against transthyretin |
| EP3876713B1 (en) | 2018-11-09 | 2024-10-02 | Neurimmune AG | Patient-derived amyloid xenograft rodent model |
| EP4121766A1 (en) | 2020-03-18 | 2023-01-25 | AL-S Pharma AG | Misfolded sod1 assay |
| CN115551886A (zh) | 2020-05-12 | 2022-12-30 | 生物控股有限公司 | 用于ttr淀粉样变性的联合疗法 |
| WO2021231982A1 (en) * | 2020-05-14 | 2021-11-18 | City Of Hope | Smc1a antibodies and uses thereof |
| JP2023548005A (ja) * | 2020-10-28 | 2023-11-15 | ノヴォ ノルディスク アー／エス | 抗トランスサイレチン抗体およびその使用方法 |
| CN113845593B (zh) * | 2021-10-27 | 2023-03-10 | 福州迈新生物技术开发有限公司 | 抗α-SMA蛋白单克隆抗体、细胞系及其应用 |
| WO2023099788A1 (en) | 2021-12-03 | 2023-06-08 | Neurimmune Ag | Novel potency assay for antibody-based drugs and useful means therefor |
| WO2024086684A2 (en) * | 2022-10-19 | 2024-04-25 | Ibio, Inc. | Chemokine receptor 8 (ccr8) antibodies |
| WO2024105062A1 (en) | 2022-11-15 | 2024-05-23 | Neurimmune Ag | Methods for treating or preventing transthyretin-mediated amyloidosis |
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| PT2099823E (pt) | 2006-12-01 | 2014-12-22 | Seattle Genetics Inc | Agentes de ligação ao alvo variantes e suas utilizações |
| TWI419902B (zh) | 2007-03-02 | 2013-12-21 | 百靈佳殷格翰製藥公司 | 蛋白質產製之改良 |
| EP2031064A1 (de) | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| FI20115165A0 (fi) * | 2011-02-21 | 2011-02-21 | Polysackaridforskning I Uppsala Ab | Terapeuttisia ja diagnostisia menetelmiä |
| US9534048B2 (en) * | 2012-08-24 | 2017-01-03 | University Health Network | Antibodies to TTR and methods of use |
| WO2014124334A2 (en) * | 2013-02-08 | 2014-08-14 | Misfolding Diagnostics, Inc. | Transthyretin antibodies and uses thereof |
| EP3022225B1 (en) | 2013-07-19 | 2021-09-29 | Board Of Regents Of the University Of Texas System | Transthyretin amyloid-selective and polyreactive catabodies |
| CU20200022A7 (es) | 2017-10-06 | 2021-01-12 | Prothena Biosciences Ltd | Métodos para detectar transtiretina |
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