HRP20230065T1 - Humanizirana protutijela koja prepoznaju alfa-sinuklein - Google Patents
Humanizirana protutijela koja prepoznaju alfa-sinuklein Download PDFInfo
- Publication number
- HRP20230065T1 HRP20230065T1 HRP20230065TT HRP20230065T HRP20230065T1 HR P20230065 T1 HRP20230065 T1 HR P20230065T1 HR P20230065T T HRP20230065T T HR P20230065TT HR P20230065 T HRP20230065 T HR P20230065T HR P20230065 T1 HRP20230065 T1 HR P20230065T1
- Authority
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- Prior art keywords
- seq
- antibody
- heavy chain
- constant region
- light chain
- Prior art date
Links
- 102000003802 alpha-Synuclein Human genes 0.000 title claims 2
- 108090000185 alpha-Synuclein Proteins 0.000 title claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 208000032859 Synucleinopathies Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (9)
1. Protutijelo, naznačeno time što sadrži humanizirani teški lanac, koji sadrži varijabilno područje zrelog teškog lanca koje ima aminokiselinski slijed označen kao SEQ ID NO: 10 ili SEQ ID NO: 8, i humanizirani laki lanac, koji sadrži varijabilno područje zrelog lakog lanca koje ima aminokiselinski slijed označen kao SEQ ID NO:5,
gdje se protutijelo veže na α-sinuklein s istim ili većim afinitetom nego protutijelo kojeg proizvodi hibridom, deponirano kao ATCC PTA-8221, te
gdje je varijabilno područje zrelog teškog lanca konjugirano s ljudski konstantno područje teškog lanca, a varijabilno područje zrelog lakog lanca je konjugirano s konstantnim područjem ljudskog lakog lanca.
2. Protutijelo u skladu s patentnim zahtjevom 1, naznačeno time što:
konstantno područje teškog lanca ima aminokiselinski slijed označen kao SEQ ID NO:14, uz uvjet da se C-terminalni lizinski ostatak može izostaviti; a
konstantno područje lakog lanca ima aminokiselinski slijed označen kao SEQ ID NO:13.
3. Protutijelo u skladu s patentnim zahtjevom 1, naznačeno time što:
konstantno područje teškog lanca ima aminokiselinski slijed označen kao SEQ ID NO:14, uz uvjet da se C-terminalni lizinski ostatak može izostaviti; a
konstantno područje lakog lanca ima aminokiselinski slijed označen kao SEQ ID NO:28.
4. Protutijelo u skladu s patentnim zahtjevom 1, naznačeno time što je konstantno područje teškog lanca ljudskog izotipa IgG1.
5. Nukleinska kiselina ili nukleinske kiseline, naznačene time što kodiraju humanizirani teški lanac i humanizirani laki lanac u skladu s bilo kojim od prethodnih patentnih zahtjeva.
6. Nukleinska kiselina ili nukleinske kiseline u skladu s patentnim zahtjevom 5, naznačene time što imaju slijed koji sadrži bilo kojeg od SEQ ID NO: 17, 18 i 20.
7. Stanica domaćin, naznačena time što sadrži vektor ili vektori koji sadrže nukleinsku kiselinu ili nukleinske kiseline u skladu s patentnim zahtjevom 5 ili 6.
8. Protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačeno time što je namijenjeno upotrebi u postupku liječenja pacijenta koji ima ili je u opasnosti da dobije sinukleinopatiju.
9. Protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačeno time što je namijenjeno upotrebi u postupku detektiranja Lewyjevih tjelešaca kod pacijenta koji ima ili je u opasnosti da dobije bolest s Lewyjevim tjelešcima, gdje se postupak sastoji u primjeni na pacijentu djelotvorne količine protutijela i detektiranju vezanog protutijela kod pacijenta.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161553131P | 2011-10-28 | 2011-10-28 | |
| US201261711208P | 2012-10-08 | 2012-10-08 | |
| EP18155441.1A EP3378535B1 (en) | 2011-10-28 | 2012-10-26 | Humanized antibodies that recognize alpha-synuclein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230065T1 true HRP20230065T1 (hr) | 2023-03-03 |
Family
ID=48168610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230065TT HRP20230065T1 (hr) | 2011-10-28 | 2012-10-26 | Humanizirana protutijela koja prepoznaju alfa-sinuklein |
| HRP20180728TT HRP20180728T1 (hr) | 2011-10-28 | 2018-05-10 | Humanizirana protutijela koja prepoznaju alfa-sinuklein |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180728TT HRP20180728T1 (hr) | 2011-10-28 | 2018-05-10 | Humanizirana protutijela koja prepoznaju alfa-sinuklein |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US8609820B2 (hr) |
| EP (2) | EP3378535B1 (hr) |
| JP (4) | JP5775974B2 (hr) |
| KR (1) | KR101600733B1 (hr) |
| CN (2) | CN104334184B (hr) |
| AU (3) | AU2012328530A1 (hr) |
| BR (1) | BR112014010198B1 (hr) |
| CA (1) | CA2853531C (hr) |
| CL (1) | CL2014001073A1 (hr) |
| CO (1) | CO7020875A2 (hr) |
| CY (1) | CY1120398T1 (hr) |
| DK (2) | DK2771031T3 (hr) |
| ES (2) | ES2669395T3 (hr) |
| FI (1) | FI3378535T3 (hr) |
| HK (3) | HK1201450A1 (hr) |
| HR (2) | HRP20230065T1 (hr) |
| HU (2) | HUE037811T2 (hr) |
| IL (2) | IL232264B (hr) |
| LT (2) | LT3378535T (hr) |
| MX (2) | MX370234B (hr) |
| MY (1) | MY165038A (hr) |
| PE (1) | PE20141568A1 (hr) |
| PL (2) | PL2771031T3 (hr) |
| PT (2) | PT2771031T (hr) |
| RS (2) | RS63930B1 (hr) |
| RU (1) | RU2743738C2 (hr) |
| SG (1) | SG11201401857WA (hr) |
| SI (2) | SI3378535T1 (hr) |
| UA (1) | UA116194C2 (hr) |
| WO (1) | WO2013063516A1 (hr) |
| ZA (1) | ZA201403864B (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9034337B2 (en) | 2003-10-31 | 2015-05-19 | Prothena Biosciences Limited | Treatment and delay of outset of synucleinopathic and amyloidogenic disease |
| US7674599B2 (en) | 2003-11-08 | 2010-03-09 | Elan Pharmaceuticals, Inc. | Methods of using antibodies to detect alpha-synuclein in fluid samples |
| BR112014010198B1 (pt) | 2011-10-28 | 2022-12-06 | Prothena Biosciences Limited | Anticorpos humanizados que reconhecem alfa-sinucleína |
| US8790644B2 (en) | 2012-01-27 | 2014-07-29 | Neotope Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| US9856319B2 (en) * | 2012-12-28 | 2018-01-02 | Abbvie Inc. | Monovalent binding proteins |
| US10513555B2 (en) * | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| US11191832B2 (en) | 2013-11-19 | 2021-12-07 | Prothena Biosciences Limited | Monitoring immunotherapy of Lewy body disease from constipation symptoms |
| JP6744856B2 (ja) | 2014-04-08 | 2020-08-19 | プロセナ・バイオサイエンシズ・リミテッド | α−シヌクレインを認識する抗体を含む血液脳関門シャトル |
| EP3207057A2 (en) | 2014-10-16 | 2017-08-23 | F. Hoffmann-La Roche AG | Anti-alpha-synuclein antibodies and methods of use |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| ES2903402T3 (es) | 2016-06-02 | 2022-04-01 | Medimmune Ltd | Anticuerpos contra alfa-sinuclueína y usos de los mismos |
| US20180328943A1 (en) * | 2016-09-30 | 2018-11-15 | Enzo Biochem, Inc. | Immunomodulatory compositions and methods of use thereof |
| RU2019114679A (ru) * | 2016-11-15 | 2020-12-17 | Х. Лундбекк А/С | Средства, пути применения и способы лечения синуклеопатии |
| JP2020501132A (ja) | 2016-12-02 | 2020-01-16 | プロセナ バイオサイエンシーズ リミテッド | α−シヌクレインの二次構造プロファイルを検出する赤外線アッセイ |
| MA47019A (fr) | 2016-12-16 | 2021-04-21 | H Lundbeck As | Agents, utilisations et procédés |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| AU2018206279B2 (en) | 2017-01-06 | 2020-09-03 | Abl Bio Inc. | Anti-alpha-syn antibody and use thereof |
| JP7136790B2 (ja) * | 2017-02-17 | 2022-09-13 | ブリストル－マイヤーズ スクイブ カンパニー | アルファ－シヌクレインに対する抗体およびその使用 |
| US11220538B2 (en) | 2017-05-01 | 2022-01-11 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against alpha-synuclein fibrils |
| EP3406632A1 (en) | 2017-05-23 | 2018-11-28 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Ligands binding to prion protein for use in the treatment of synucleinopathies |
| EP3672635A4 (en) | 2017-08-23 | 2021-05-12 | The Trustees of The University of Pennsylvania | MONOCLONAL ANTIBODIES AGAINST PATHOLOGICAL ALPHA-SYNUCLEIN, AND METHODS USING THEM |
| CA3085572A1 (en) * | 2017-12-14 | 2019-06-20 | Abl Bio Inc. | Bispecific antibody to a-syn/igf1r and use thereof |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| NL2020520B1 (en) * | 2018-03-02 | 2019-09-12 | Labo Bio Medical Invest B V | Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders |
| EP3833435A4 (en) | 2018-08-09 | 2022-05-11 | F. Hoffmann-La Roche AG | DETERMINATION OF PARKINSON'S DISEASE |
| TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
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