HRP20180517T1 - Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba - Google Patents
Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba Download PDFInfo
- Publication number
- HRP20180517T1 HRP20180517T1 HRP20180517TT HRP20180517T HRP20180517T1 HR P20180517 T1 HRP20180517 T1 HR P20180517T1 HR P20180517T T HRP20180517T T HR P20180517TT HR P20180517 T HRP20180517 T HR P20180517T HR P20180517 T1 HRP20180517 T1 HR P20180517T1
- Authority
- HR
- Croatia
- Prior art keywords
- bispecific antibody
- humanized bispecific
- antibody
- seq
- variable
- Prior art date
Links
- 102000004388 Interleukin-4 Human genes 0.000 claims 4
- 108090000978 Interleukin-4 Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (13)
1. Humanizirano bispecifično protutijelo koje se specifično veže na IL-13 i IL-4, naznačeno time da je humanizirano bispecifično protutijelo molekula IgG koja je izdužena na njezinom N-terminalnom kraju na odgovarajućim teškim i laganim lancima pomoću dodatne varijabilne domene drugog protutijela, pri čemu nastala molekula IgG je heterotetramer sastavljen od dva teška i dva lagana lanca,
pri čemu teški lanci sadrže dvije varijabilne domene teškog lanca (VH1 - VH2) koje su izvedene iz dva različita protutijela međusobno spojena s poveznicom sastavljenom od deset amino kiselina (G4S)2 i kondenzirana na konstantnu IgG4 domenu,
pri čemu lagani lanci sadrže dvije varijabilne lake domene (VL1 - VL2) koje su izvedene iz dva različita protutijela međusobno spojena s poveznicom sastavljenom od deset amino kiselina (G4S)2 i kondenzirana na konstantnu kapa regiju, te
pri čemu dva različita protutijela su protutijelo koje specifično veže IL-13 i protutijelo koje specifično veže IL-4,
pri čemu protutijelo koje specifično veže IL-4 obuhvaća varijabilni laki lanac koji sadrži SEQ ID NO:3 i varijabilni teški lanac koji sadrži SEQ ID NO:4 ili sadrži varijabilni laki lanac koji sadrži SEQ ID NO:3 i varijabilni teški lanac koji sadrži SEQ ID NO:5, te protutijelo koje specifično veže IL-13 sadrži varijabilni teški lanac koji sadrži SEQ ID NO:1 i sadrži varijabilni laki lanac koji sadrži SEQ ID NO:2.
2. Humanizirano bispecifično protutijelo prema zahtjevu 1 naznačeno time da nadalje sadrži domene konstantne regije, pri čemu se domene konstantne regije poželjno sastoje od CH1, CH2, CH3 i CL.
3. Humanizirano bispecifično protutijelo prema zahtjevu 1 ili 2, naznačeno time da protutijelo neutralizira aktivnost IL-4 i/ili IL-13.
4. Humanizirano bispecifično protutijelo prema bilo kojem od zahtjeva 1 do 3 naznačeno time da je nadalje konjugirano na efektorsku molekulu, pri čemu je efektorska molekula poželjno odabrana iz skupine koju čine heterologni polipeptidi, lijekovi, radionukleotidi i toksini.
5. Farmaceutski pripravak naznačen time da sadrži humanizirano bispecifično protutijelo prema bilo kojem od zahtjeva 1 do 4 i farmaceutski prihvatljiv nosač.
6. Molekula nukleinske kiseline naznačena time da kodira humanizirano bispecifično protutijelo prema bilo kojem od zahtjeva 1 do 3.
7. Vektor naznačen time da sadrži molekulu nukleinske kiseline prema zahtjevu 6.
8. Stanica domaćina naznačena time da sadrži vektor prema zahtjevu 7.
9. Postupak za proizvodnju humaniziranog bispecifičnog protutijela prema bilo kojem od zahtjeva 1 do 3 naznačen time da sadrži ekspresiju molekule nukleinske kiseline iz zahtjeva 8 u prikladnoj stanici domaćina.
10. Humanizirano bispecifično protutijelo bilo kojem od zahtjeva 1 do 4 naznačeno time da je za uporabu za liječenje, suzbijanje ili prevenciju bolesti.
11. Humanizirano bispecifično protutijelo za uporabu prema zahtjevu 10, naznačeno time da je bolest odabrana iz skupine koju čine alergijska bolest, astma, rak, autoimuna bolest, skleroderma i idiopatska plućna fibroza.
12. Uporaba humaniziranog bispecifičnog protutijela iz bilo kojeg od patentnih zahtjeva 1 do 4 za istraživačke primjene, naznačena time da navedeno protutijelo sadrži oznaku kao što je radioaktivna oznaka, fluorofor, kromofor, sredstvo za snimanje ili metalni ion.
13. Komplet naznačen time da sadrži humanizirano bispecifično protutijelo prema bilo kojem od zahtjeva 1 do 4 i upute za uporabu.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07291259A EP2050764A1 (en) | 2007-10-15 | 2007-10-15 | Novel polyvalent bispecific antibody format and uses thereof |
US3712808P | 2008-03-17 | 2008-03-17 | |
EP12006797.0A EP2573119B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20180517T1 true HRP20180517T1 (hr) | 2018-05-04 |
Family
ID=39313041
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20140150AT HRP20140150T1 (hr) | 2007-10-15 | 2014-02-18 | Antitijela koja vežu il-4 i/ili il-13 i njihova uporaba |
HRP20171765TT HRP20171765T1 (hr) | 2007-10-15 | 2017-11-16 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
HRP20180320TT HRP20180320T1 (hr) | 2007-10-15 | 2018-02-21 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
HRP20180517TT HRP20180517T1 (hr) | 2007-10-15 | 2018-03-27 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
HRP20181085TT HRP20181085T1 (hr) | 2007-10-15 | 2018-07-10 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20140150AT HRP20140150T1 (hr) | 2007-10-15 | 2014-02-18 | Antitijela koja vežu il-4 i/ili il-13 i njihova uporaba |
HRP20171765TT HRP20171765T1 (hr) | 2007-10-15 | 2017-11-16 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
HRP20180320TT HRP20180320T1 (hr) | 2007-10-15 | 2018-02-21 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181085TT HRP20181085T1 (hr) | 2007-10-15 | 2018-07-10 | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba |
Country Status (43)
Families Citing this family (165)
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WO2009040562A1 (en) | 2007-09-26 | 2009-04-02 | Ucb Pharma S.A. | Dual specificity antibody fusions |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
GB2468232B (en) * | 2007-11-30 | 2012-10-24 | Glaxo Group Ltd | Antigen-bindng constructs |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
MX2011001696A (es) * | 2008-08-14 | 2011-03-25 | Merck Sharp & Dohme | Metodos para purificar anticuerpos usando cromatografia de afinidad con proteina a. |
SI2334705T1 (sl) | 2008-09-26 | 2017-05-31 | Ucb Biopharma Sprl | Biološki produkti |
CA2756244A1 (en) | 2009-04-02 | 2010-10-07 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
CA2757931C (en) | 2009-04-07 | 2019-03-26 | Roche Glycart Ag | Trivalent, bispecific antibodies |
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WO2011030107A1 (en) * | 2009-09-10 | 2011-03-17 | Ucb Pharma S.A. | Multivalent antibodies |
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